Epicardial adipose tissue is associated with cardiorespiratory fitness and hemodynamics among Japanese individuals of various ages and of both sexes.

Epicardial adipose tissue may affect hemodynamics and cardiorespiratory fitness as it is a metabolically active visceral adipose tissue and a source of inflammatory bioactive substances that can substantially modulate cardiovascular morphology and function. However, the associations between epicardi...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yousuke Sugita, Katsuhiko Ito, Shigeki Sakurai, Satoshi Sakai, Shinya Kuno
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8ed5a5f0d3e64791aa13fd4c7fac606d
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:8ed5a5f0d3e64791aa13fd4c7fac606d
record_format	dspace
spelling	oai:doaj.org-article:8ed5a5f0d3e64791aa13fd4c7fac606d2021-12-02T20:06:59ZEpicardial adipose tissue is associated with cardiorespiratory fitness and hemodynamics among Japanese individuals of various ages and of both sexes.1932-620310.1371/journal.pone.0254733https://doaj.org/article/8ed5a5f0d3e64791aa13fd4c7fac606d2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0254733https://doaj.org/toc/1932-6203Epicardial adipose tissue may affect hemodynamics and cardiorespiratory fitness as it is a metabolically active visceral adipose tissue and a source of inflammatory bioactive substances that can substantially modulate cardiovascular morphology and function. However, the associations between epicardial adipose tissue and hemodynamics and cardiorespiratory fitness remain unclear. This cross-sectional study aimed to examine the association between epicardial adipose tissue volume and hemodynamics, and cardiorespiratory fitness among Japanese individuals of various ages and of both sexes. Epicardial adipose tissue volume was measured in 120 participants (age, 21-85 years) by cardiac magnetic resonance imaging. To evaluate cardiorespiratory fitness, peak oxygen uptake was measured by cardiopulmonary exercise testing. Peak cardiac output and arteriovenous oxygen difference were calculated by impedance cardiography. The epicardial adipose tissue volume was significantly increased in middle-aged and older women. The epicardial adipose tissue volume was significantly and negatively correlated to peak cardiac output and peak oxygen uptake, regardless of age and sex; furthermore, epicardial adipose tissue showed a strong negative correlation with peak heart rate. Epicardial adipose tissue and peak cardiac output were significantly associated (β = -0.359, 95% confidence interval, -0.119 to -0.049, p < 0.001), even after multivariate adjustment (R2 = 0.778). However, in the multiple regression analysis with peak oxygen uptake as a dependent variable, the epicardial adipose tissue volume was not an independent predictor. These data suggest that increased epicardial adipose tissue volume may be correlated with decreased peak oxygen uptake, which might have mediated the abnormal hemodynamics among Japanese people of various ages and of both sexes. Interventions targeting epicardial adipose tissue could potentially improve hemodynamics and cardiorespiratory fitness.Yousuke SugitaKatsuhiko ItoShigeki SakuraiSatoshi SakaiShinya KunoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 7, p e0254733 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yousuke Sugita Katsuhiko Ito Shigeki Sakurai Satoshi Sakai Shinya Kuno Epicardial adipose tissue is associated with cardiorespiratory fitness and hemodynamics among Japanese individuals of various ages and of both sexes.
description	Epicardial adipose tissue may affect hemodynamics and cardiorespiratory fitness as it is a metabolically active visceral adipose tissue and a source of inflammatory bioactive substances that can substantially modulate cardiovascular morphology and function. However, the associations between epicardial adipose tissue and hemodynamics and cardiorespiratory fitness remain unclear. This cross-sectional study aimed to examine the association between epicardial adipose tissue volume and hemodynamics, and cardiorespiratory fitness among Japanese individuals of various ages and of both sexes. Epicardial adipose tissue volume was measured in 120 participants (age, 21-85 years) by cardiac magnetic resonance imaging. To evaluate cardiorespiratory fitness, peak oxygen uptake was measured by cardiopulmonary exercise testing. Peak cardiac output and arteriovenous oxygen difference were calculated by impedance cardiography. The epicardial adipose tissue volume was significantly increased in middle-aged and older women. The epicardial adipose tissue volume was significantly and negatively correlated to peak cardiac output and peak oxygen uptake, regardless of age and sex; furthermore, epicardial adipose tissue showed a strong negative correlation with peak heart rate. Epicardial adipose tissue and peak cardiac output were significantly associated (β = -0.359, 95% confidence interval, -0.119 to -0.049, p < 0.001), even after multivariate adjustment (R2 = 0.778). However, in the multiple regression analysis with peak oxygen uptake as a dependent variable, the epicardial adipose tissue volume was not an independent predictor. These data suggest that increased epicardial adipose tissue volume may be correlated with decreased peak oxygen uptake, which might have mediated the abnormal hemodynamics among Japanese people of various ages and of both sexes. Interventions targeting epicardial adipose tissue could potentially improve hemodynamics and cardiorespiratory fitness.
format	article
author	Yousuke Sugita Katsuhiko Ito Shigeki Sakurai Satoshi Sakai Shinya Kuno
author_facet	Yousuke Sugita Katsuhiko Ito Shigeki Sakurai Satoshi Sakai Shinya Kuno
author_sort	Yousuke Sugita
title	Epicardial adipose tissue is associated with cardiorespiratory fitness and hemodynamics among Japanese individuals of various ages and of both sexes.
title_short	Epicardial adipose tissue is associated with cardiorespiratory fitness and hemodynamics among Japanese individuals of various ages and of both sexes.
title_full	Epicardial adipose tissue is associated with cardiorespiratory fitness and hemodynamics among Japanese individuals of various ages and of both sexes.
title_fullStr	Epicardial adipose tissue is associated with cardiorespiratory fitness and hemodynamics among Japanese individuals of various ages and of both sexes.
title_full_unstemmed	Epicardial adipose tissue is associated with cardiorespiratory fitness and hemodynamics among Japanese individuals of various ages and of both sexes.
title_sort	epicardial adipose tissue is associated with cardiorespiratory fitness and hemodynamics among japanese individuals of various ages and of both sexes.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/8ed5a5f0d3e64791aa13fd4c7fac606d
work_keys_str_mv	AT yousukesugita epicardialadiposetissueisassociatedwithcardiorespiratoryfitnessandhemodynamicsamongjapaneseindividualsofvariousagesandofbothsexes AT katsuhikoito epicardialadiposetissueisassociatedwithcardiorespiratoryfitnessandhemodynamicsamongjapaneseindividualsofvariousagesandofbothsexes AT shigekisakurai epicardialadiposetissueisassociatedwithcardiorespiratoryfitnessandhemodynamicsamongjapaneseindividualsofvariousagesandofbothsexes AT satoshisakai epicardialadiposetissueisassociatedwithcardiorespiratoryfitnessandhemodynamicsamongjapaneseindividualsofvariousagesandofbothsexes AT shinyakuno epicardialadiposetissueisassociatedwithcardiorespiratoryfitnessandhemodynamicsamongjapaneseindividualsofvariousagesandofbothsexes
_version_	1718375315656409088

Epicardial adipose tissue is associated with cardiorespiratory fitness and hemodynamics among Japanese individuals of various ages and of both sexes.

Ejemplares similares