Step-wise assembly, maturation and dynamic behavior of the human CENP-P/O/R/Q/U kinetochore sub-complex.

Step-wise assembly, maturation and dynamic behavior of the human CENP-P/O/R/Q/U kinetochore sub-complex.

Kinetochores are multi-protein megadalton assemblies that are required for attachment of microtubules to centromeres and, in turn, the segregation of chromosomes in mitosis. Kinetochore assembly is a cell cycle regulated multi-step process. The initial step occurs during interphase and involves load...

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Autores principales: Anja Eskat, Wen Deng, Antje Hofmeister, Sven Rudolphi, Stephan Emmerth, Daniela Hellwig, Tobias Ulbricht, Volker Döring, James M Bancroft, Andrew D McAinsh, M Cristina Cardoso, Patrick Meraldi, Christian Hoischen, Heinrich Leonhardt, Stephan Diekmann
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/8ed63ac13a1540678c3a656df8c11a91
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