Exploring willingness to participate in future Human Infection Studies in Lusaka, Zambia: A nested qualitative exploratory study.

Human Infection Studies (HIC) involve intentional infection of volunteers with a challenge agent or pathogen with the aim of understanding and developing vaccines as well as understanding the disease pathophysiology in a well-controlled environment. Though Africa carries the highest burden of vaccin...

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Autores principales:	Evelyn Muleba Kunda-Ngándu, Masuzyo Chirwa-Chobe, Chanda Mwamba, Jenala Chipungu, Esnart Ng'andu, Hope Mwanyungwi Chinganya, Michelo Simuyandi, Roma Chilengi, Anjali Sharma
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8ed7c5255e5d4bb78d9fd5986be689ce
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spelling	oai:doaj.org-article:8ed7c5255e5d4bb78d9fd5986be689ce2021-12-02T20:09:21ZExploring willingness to participate in future Human Infection Studies in Lusaka, Zambia: A nested qualitative exploratory study.1932-620310.1371/journal.pone.0254278https://doaj.org/article/8ed7c5255e5d4bb78d9fd5986be689ce2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0254278https://doaj.org/toc/1932-6203Human Infection Studies (HIC) involve intentional infection of volunteers with a challenge agent or pathogen with the aim of understanding and developing vaccines as well as understanding the disease pathophysiology in a well-controlled environment. Though Africa carries the highest burden of vaccine-preventable diseases, the region is only now being primed to conduct HIC relevant to its population. Given the imminent introduction of HIC in Zambia, we sought to understand potential participants' willingness to volunteer for such studies. We used a qualitative exploratory approach to understand the potential participants' perceptions on willingness to participate in HIC using the example of typhoid. Healthy adults, recruited using random selection and purposive sampling from higher learning institutions in Lusaka, participated in 15 in-depth interviews (IDIs) and 5 Focus Group Discussions (FGDs) respectively. Participants considered typhoid a serious disease with potential for life-long consequences and death. After sharing audio-visual materials introducing the concepts of HIC, some participants expressed open willingness to participate or alternatively the need to consult parents and professors, and expressed fear of death and illness. Though willing to be quarantined for up to six months, participants expressed concerns regarding separation from family and duties, having insufficient information to decide, inadequate access to care, severe disease, life-long injury or side-effects, death, and vaccine failure. These concerns along with possibility of underlying conditions that compromise individual immunity, competing priorities, parental refusal, and distrust of study or vaccine efficacy could lead to refusal to participate. Reasons for willingness to participate included monetary compensation, altruism and being part of a team that comes up with a vaccine. Though afraid of deliberate typhoid infection, potential participants are willing to consider participation if given adequate information, time to consult trusted persons, compensation and assurance of adequate care.Evelyn Muleba Kunda-NgánduMasuzyo Chirwa-ChobeChanda MwambaJenala ChipunguEsnart Ng'anduHope Mwanyungwi ChinganyaMichelo SimuyandiRoma ChilengiAnjali SharmaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 7, p e0254278 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Evelyn Muleba Kunda-Ngándu Masuzyo Chirwa-Chobe Chanda Mwamba Jenala Chipungu Esnart Ng'andu Hope Mwanyungwi Chinganya Michelo Simuyandi Roma Chilengi Anjali Sharma Exploring willingness to participate in future Human Infection Studies in Lusaka, Zambia: A nested qualitative exploratory study.
description	Human Infection Studies (HIC) involve intentional infection of volunteers with a challenge agent or pathogen with the aim of understanding and developing vaccines as well as understanding the disease pathophysiology in a well-controlled environment. Though Africa carries the highest burden of vaccine-preventable diseases, the region is only now being primed to conduct HIC relevant to its population. Given the imminent introduction of HIC in Zambia, we sought to understand potential participants' willingness to volunteer for such studies. We used a qualitative exploratory approach to understand the potential participants' perceptions on willingness to participate in HIC using the example of typhoid. Healthy adults, recruited using random selection and purposive sampling from higher learning institutions in Lusaka, participated in 15 in-depth interviews (IDIs) and 5 Focus Group Discussions (FGDs) respectively. Participants considered typhoid a serious disease with potential for life-long consequences and death. After sharing audio-visual materials introducing the concepts of HIC, some participants expressed open willingness to participate or alternatively the need to consult parents and professors, and expressed fear of death and illness. Though willing to be quarantined for up to six months, participants expressed concerns regarding separation from family and duties, having insufficient information to decide, inadequate access to care, severe disease, life-long injury or side-effects, death, and vaccine failure. These concerns along with possibility of underlying conditions that compromise individual immunity, competing priorities, parental refusal, and distrust of study or vaccine efficacy could lead to refusal to participate. Reasons for willingness to participate included monetary compensation, altruism and being part of a team that comes up with a vaccine. Though afraid of deliberate typhoid infection, potential participants are willing to consider participation if given adequate information, time to consult trusted persons, compensation and assurance of adequate care.
format	article
author	Evelyn Muleba Kunda-Ngándu Masuzyo Chirwa-Chobe Chanda Mwamba Jenala Chipungu Esnart Ng'andu Hope Mwanyungwi Chinganya Michelo Simuyandi Roma Chilengi Anjali Sharma
author_facet	Evelyn Muleba Kunda-Ngándu Masuzyo Chirwa-Chobe Chanda Mwamba Jenala Chipungu Esnart Ng'andu Hope Mwanyungwi Chinganya Michelo Simuyandi Roma Chilengi Anjali Sharma
author_sort	Evelyn Muleba Kunda-Ngándu
title	Exploring willingness to participate in future Human Infection Studies in Lusaka, Zambia: A nested qualitative exploratory study.
title_short	Exploring willingness to participate in future Human Infection Studies in Lusaka, Zambia: A nested qualitative exploratory study.
title_full	Exploring willingness to participate in future Human Infection Studies in Lusaka, Zambia: A nested qualitative exploratory study.
title_fullStr	Exploring willingness to participate in future Human Infection Studies in Lusaka, Zambia: A nested qualitative exploratory study.
title_full_unstemmed	Exploring willingness to participate in future Human Infection Studies in Lusaka, Zambia: A nested qualitative exploratory study.
title_sort	exploring willingness to participate in future human infection studies in lusaka, zambia: a nested qualitative exploratory study.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/8ed7c5255e5d4bb78d9fd5986be689ce
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Exploring willingness to participate in future Human Infection Studies in Lusaka, Zambia: A nested qualitative exploratory study.

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