Epidemiology of keratitis/scleritis-related endophthalmitis in a university hospital in Thailand

Abstract To demonstrate the demographics, associated factors, clinical presentations, microbiology, management, visual outcome and complications of keratitis/scleritis-related endophthalmitis (KSE). A retrospective chart of all endophthalmitis patients diagnosed between September 2001 and August 201...

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Autores principales:	Dhanach Dhirachaikulpanich, Kunravitch Soraprajum, Sutasinee Boonsopon, Warinyupa Pinitpuwadol, Preeyachan Lourthai, Noppakhun Punyayingyong, Nattaporn Tesavibul, Pitipol Choopong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8eda1d6bb7644f8ba0463e11a607b6cc
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spelling	oai:doaj.org-article:8eda1d6bb7644f8ba0463e11a607b6cc2021-12-02T14:49:11ZEpidemiology of keratitis/scleritis-related endophthalmitis in a university hospital in Thailand10.1038/s41598-021-90815-12045-2322https://doaj.org/article/8eda1d6bb7644f8ba0463e11a607b6cc2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90815-1https://doaj.org/toc/2045-2322Abstract To demonstrate the demographics, associated factors, clinical presentations, microbiology, management, visual outcome and complications of keratitis/scleritis-related endophthalmitis (KSE). A retrospective chart of all endophthalmitis patients diagnosed between September 2001 and August 2011 was reviewed. Only endophthalmitis cases with previous corneal or scleral infection were included in the study. The patients were followed until losing vision or eyeball, becoming phthisis, or the end of 2018. Eighty-seven patients with KSE were identified, all unilateral. The mean age was 56.4 ± 21.4 years. There was a slight male predilection (55 patients, 63.2%). The mean follow-up time was 50 ± 149 weeks. The causative pathogens were identified in 35 patients (40.2%), with the highest frequency being bacteria. The most common bacterium was Pseudomonas aeruginosa (n = 13), and the most common fungus was Aspergillus sp. (n = 5). Fifteen patients achieved (17.2%) final visual acuity (VA) of hand motion or better after treatment. Eyeball removal was performed in 61 (70.1%) patients. From multivariate analysis, the only prognostic factor for poor final VA (worse than hand motion, HM) was poor VA (worse than HM) at the initial visit (relative risk 1.97, 95% confidence interval 1.15–3.36, p = 0.013). KSE is uncommon but has a devastating outcome. We found that the patient’s initial VA was the only predictor for their final vision. P. aeruginosa was the most common identifiable organism in this study. However, several fungal infections were recognised. These findings should raise awareness for treatment of KSE in the tropics.Dhanach DhirachaikulpanichKunravitch SoraprajumSutasinee BoonsoponWarinyupa PinitpuwadolPreeyachan LourthaiNoppakhun PunyayingyongNattaporn TesavibulPitipol ChoopongNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Dhanach Dhirachaikulpanich Kunravitch Soraprajum Sutasinee Boonsopon Warinyupa Pinitpuwadol Preeyachan Lourthai Noppakhun Punyayingyong Nattaporn Tesavibul Pitipol Choopong Epidemiology of keratitis/scleritis-related endophthalmitis in a university hospital in Thailand
description	Abstract To demonstrate the demographics, associated factors, clinical presentations, microbiology, management, visual outcome and complications of keratitis/scleritis-related endophthalmitis (KSE). A retrospective chart of all endophthalmitis patients diagnosed between September 2001 and August 2011 was reviewed. Only endophthalmitis cases with previous corneal or scleral infection were included in the study. The patients were followed until losing vision or eyeball, becoming phthisis, or the end of 2018. Eighty-seven patients with KSE were identified, all unilateral. The mean age was 56.4 ± 21.4 years. There was a slight male predilection (55 patients, 63.2%). The mean follow-up time was 50 ± 149 weeks. The causative pathogens were identified in 35 patients (40.2%), with the highest frequency being bacteria. The most common bacterium was Pseudomonas aeruginosa (n = 13), and the most common fungus was Aspergillus sp. (n = 5). Fifteen patients achieved (17.2%) final visual acuity (VA) of hand motion or better after treatment. Eyeball removal was performed in 61 (70.1%) patients. From multivariate analysis, the only prognostic factor for poor final VA (worse than hand motion, HM) was poor VA (worse than HM) at the initial visit (relative risk 1.97, 95% confidence interval 1.15–3.36, p = 0.013). KSE is uncommon but has a devastating outcome. We found that the patient’s initial VA was the only predictor for their final vision. P. aeruginosa was the most common identifiable organism in this study. However, several fungal infections were recognised. These findings should raise awareness for treatment of KSE in the tropics.
format	article
author	Dhanach Dhirachaikulpanich Kunravitch Soraprajum Sutasinee Boonsopon Warinyupa Pinitpuwadol Preeyachan Lourthai Noppakhun Punyayingyong Nattaporn Tesavibul Pitipol Choopong
author_facet	Dhanach Dhirachaikulpanich Kunravitch Soraprajum Sutasinee Boonsopon Warinyupa Pinitpuwadol Preeyachan Lourthai Noppakhun Punyayingyong Nattaporn Tesavibul Pitipol Choopong
author_sort	Dhanach Dhirachaikulpanich
title	Epidemiology of keratitis/scleritis-related endophthalmitis in a university hospital in Thailand
title_short	Epidemiology of keratitis/scleritis-related endophthalmitis in a university hospital in Thailand
title_full	Epidemiology of keratitis/scleritis-related endophthalmitis in a university hospital in Thailand
title_fullStr	Epidemiology of keratitis/scleritis-related endophthalmitis in a university hospital in Thailand
title_full_unstemmed	Epidemiology of keratitis/scleritis-related endophthalmitis in a university hospital in Thailand
title_sort	epidemiology of keratitis/scleritis-related endophthalmitis in a university hospital in thailand
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8eda1d6bb7644f8ba0463e11a607b6cc
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_version_	1718389523081068544

Epidemiology of keratitis/scleritis-related endophthalmitis in a university hospital in Thailand

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