Treatment and prevention of mania in bipolar I disorder: focus on aripiprazole
David J MuzinaCenter for Mood Disorders Treatment and Research, Cleveland Clinic Neurological Institute, Cleveland, Ohio, USAAbstract: Aripiprazole is a second-generation antipsychotic with a unique pharmacologic receptor profile that has efficacy in the treatment and prevention of mania in bipolar...
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Dove Medical Press
2009
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oai:doaj.org-article:8edaac38d1744b8db2d2aca0b163fd312021-12-02T07:49:27ZTreatment and prevention of mania in bipolar I disorder: focus on aripiprazole1176-63281178-2021https://doaj.org/article/8edaac38d1744b8db2d2aca0b163fd312009-05-01T00:00:00Zhttp://www.dovepress.com/treatment-and-prevention-of-mania-in-bipolarnbspi-disorder-focus-on-ar-a3148https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021David J MuzinaCenter for Mood Disorders Treatment and Research, Cleveland Clinic Neurological Institute, Cleveland, Ohio, USAAbstract: Aripiprazole is a second-generation antipsychotic with a unique pharmacologic receptor profile that has efficacy in the treatment and prevention of mania in bipolar I disorder. This article reviews the evidence supporting treatment of adults with bipolar I disorder using aripiprazole as monotherapy or adjunctively during acute mania and its utility as an intramuscular agent for agitation in manic patients. Results from one of the longest bipolar maintenance trials which support aripiprazole as a prophylactic mood stabilizer, specifically against manic relapses, will be discussed as well as a post-hoc analysis that suggests efficacy for rapid cycling bipolar disorder. Safety and tolerability issues, patient-focused perspectives and aripiprazole’s place in therapy for bipolar mania will be covered.Keywords: bipolar disorder, mania, prevention, aripiprazole, rapid cycling David J MuzinaDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2009, Iss default, Pp 279-288 (2009) |
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DOAJ |
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EN |
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Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 |
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Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 David J Muzina Treatment and prevention of mania in bipolar I disorder: focus on aripiprazole |
| description |
David J MuzinaCenter for Mood Disorders Treatment and Research, Cleveland Clinic Neurological Institute, Cleveland, Ohio, USAAbstract: Aripiprazole is a second-generation antipsychotic with a unique pharmacologic receptor profile that has efficacy in the treatment and prevention of mania in bipolar I disorder. This article reviews the evidence supporting treatment of adults with bipolar I disorder using aripiprazole as monotherapy or adjunctively during acute mania and its utility as an intramuscular agent for agitation in manic patients. Results from one of the longest bipolar maintenance trials which support aripiprazole as a prophylactic mood stabilizer, specifically against manic relapses, will be discussed as well as a post-hoc analysis that suggests efficacy for rapid cycling bipolar disorder. Safety and tolerability issues, patient-focused perspectives and aripiprazole’s place in therapy for bipolar mania will be covered.Keywords: bipolar disorder, mania, prevention, aripiprazole, rapid cycling |
| format |
article |
| author |
David J Muzina |
| author_facet |
David J Muzina |
| author_sort |
David J Muzina |
| title |
Treatment and prevention of mania in bipolar I disorder: focus on aripiprazole |
| title_short |
Treatment and prevention of mania in bipolar I disorder: focus on aripiprazole |
| title_full |
Treatment and prevention of mania in bipolar I disorder: focus on aripiprazole |
| title_fullStr |
Treatment and prevention of mania in bipolar I disorder: focus on aripiprazole |
| title_full_unstemmed |
Treatment and prevention of mania in bipolar I disorder: focus on aripiprazole |
| title_sort |
treatment and prevention of mania in bipolar i disorder: focus on aripiprazole |
| publisher |
Dove Medical Press |
| publishDate |
2009 |
| url |
https://doaj.org/article/8edaac38d1744b8db2d2aca0b163fd31 |
| work_keys_str_mv |
AT davidjmuzina treatmentandpreventionofmaniainbipolarampnbspidisorderfocusonaripiprazole |
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1718399170088271872 |