A study on the curative effect of nobiletin on paraquat induced toxicity in rat

This research aimed to evaluate the curative impact of nobiletin (NOB) on paraquat (PQ) induced mitochondrial impairment in rats' hepatic tissues. Twenty-four male rats were divided into control, PQ, PQ + NOB, and NOB treated groups. The alanine aminotransferase levels, aspartate aminotransfera...

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Autores principales:	Muhammad Umar Ijaz, Moazama Batool, Asma Ashraf, K.A. Al-Ghanim, Sabahat Shahzadi, Abdul Samad, F. Al-Misned, Satyanarayana Swamy Mruthinti, Shahid Mahboob
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	Paraquat Nobiletin Liver Rat Mitochondria Science (General) Q1-390
Acceso en línea:	https://doaj.org/article/8edc68c1b4a34e05b146763804038e03
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spelling	oai:doaj.org-article:8edc68c1b4a34e05b146763804038e032021-11-12T04:26:49ZA study on the curative effect of nobiletin on paraquat induced toxicity in rat1018-364710.1016/j.jksus.2021.101673https://doaj.org/article/8edc68c1b4a34e05b146763804038e032022-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1018364721003359https://doaj.org/toc/1018-3647This research aimed to evaluate the curative impact of nobiletin (NOB) on paraquat (PQ) induced mitochondrial impairment in rats' hepatic tissues. Twenty-four male rats were divided into control, PQ, PQ + NOB, and NOB treated groups. The alanine aminotransferase levels, aspartate aminotransferase, and alkaline phosphatase were increased in the experimental animals after exposure with PQ. A significant decrease in the level of catalase, glutathione peroxidase, superoxide dismutase, glutathione, thiobarbituric acid reactive substances, and reactive oxygen species were recorded in rats exposed to PQ. The mitochondrial TCA cycle enzyme activities, including isocitrate-dehydrogenase, succinate-dehydrogenase, alpha-ketoglutarate dehydrogenase, and malate-dehydrogenase, were reduced in PQ exposed rats. The activities of mitochondrial enzymes including NADH dehydrogenase, coenzyme Q-cytochrome reductase, succinic-coenzyme Q and cytochrome c-oxidase were significantly decreased after the PQ-exposure. PQ administration also reduced the mitochondrial membrane potential. However, the administration of mitochondria with NOB can decrease the toxic effect of the PQ in isolated mitochondria. NOB treatment potentially reduced the damaging effects of the PQ in the mitochondria isolated from hepatic tissues. Thus, the current study revealed that the NOB could attenuate PQ-induced mitochondrial damage in rats' hepatic tissues.Muhammad Umar IjazMoazama BatoolAsma AshrafK.A. Al-GhanimSabahat ShahzadiAbdul SamadF. Al-MisnedSatyanarayana Swamy MruthintiShahid MahboobElsevierarticleParaquatNobiletinLiverRatMitochondriaScience (General)Q1-390ENJournal of King Saud University: Science, Vol 34, Iss 1, Pp 101673- (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Paraquat Nobiletin Liver Rat Mitochondria Science (General) Q1-390
spellingShingle	Paraquat Nobiletin Liver Rat Mitochondria Science (General) Q1-390 Muhammad Umar Ijaz Moazama Batool Asma Ashraf K.A. Al-Ghanim Sabahat Shahzadi Abdul Samad F. Al-Misned Satyanarayana Swamy Mruthinti Shahid Mahboob A study on the curative effect of nobiletin on paraquat induced toxicity in rat
description	This research aimed to evaluate the curative impact of nobiletin (NOB) on paraquat (PQ) induced mitochondrial impairment in rats' hepatic tissues. Twenty-four male rats were divided into control, PQ, PQ + NOB, and NOB treated groups. The alanine aminotransferase levels, aspartate aminotransferase, and alkaline phosphatase were increased in the experimental animals after exposure with PQ. A significant decrease in the level of catalase, glutathione peroxidase, superoxide dismutase, glutathione, thiobarbituric acid reactive substances, and reactive oxygen species were recorded in rats exposed to PQ. The mitochondrial TCA cycle enzyme activities, including isocitrate-dehydrogenase, succinate-dehydrogenase, alpha-ketoglutarate dehydrogenase, and malate-dehydrogenase, were reduced in PQ exposed rats. The activities of mitochondrial enzymes including NADH dehydrogenase, coenzyme Q-cytochrome reductase, succinic-coenzyme Q and cytochrome c-oxidase were significantly decreased after the PQ-exposure. PQ administration also reduced the mitochondrial membrane potential. However, the administration of mitochondria with NOB can decrease the toxic effect of the PQ in isolated mitochondria. NOB treatment potentially reduced the damaging effects of the PQ in the mitochondria isolated from hepatic tissues. Thus, the current study revealed that the NOB could attenuate PQ-induced mitochondrial damage in rats' hepatic tissues.
format	article
author	Muhammad Umar Ijaz Moazama Batool Asma Ashraf K.A. Al-Ghanim Sabahat Shahzadi Abdul Samad F. Al-Misned Satyanarayana Swamy Mruthinti Shahid Mahboob
author_facet	Muhammad Umar Ijaz Moazama Batool Asma Ashraf K.A. Al-Ghanim Sabahat Shahzadi Abdul Samad F. Al-Misned Satyanarayana Swamy Mruthinti Shahid Mahboob
author_sort	Muhammad Umar Ijaz
title	A study on the curative effect of nobiletin on paraquat induced toxicity in rat
title_short	A study on the curative effect of nobiletin on paraquat induced toxicity in rat
title_full	A study on the curative effect of nobiletin on paraquat induced toxicity in rat
title_fullStr	A study on the curative effect of nobiletin on paraquat induced toxicity in rat
title_full_unstemmed	A study on the curative effect of nobiletin on paraquat induced toxicity in rat
title_sort	study on the curative effect of nobiletin on paraquat induced toxicity in rat
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/8edc68c1b4a34e05b146763804038e03
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A study on the curative effect of nobiletin on paraquat induced toxicity in rat

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