The emerging role of bexarotene in the treatment of Alzheimer’s disease: current evidence
Babak Tousi Cleveland Clinic Lou Ruvo Center for Brian Health, Neurological Institute, Cleveland, OH, USA Abstract: In 2012, a novel approach to the treatment of Alzheimer’s disease was introduced, heralding a wave of excitement in the field of dementia. Bexarotene, a retinoid...
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Dove Medical Press
2015
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oai:doaj.org-article:8edce817ae674701824517ad8d322f7e2021-12-02T01:29:21ZThe emerging role of bexarotene in the treatment of Alzheimer’s disease: current evidence1178-2021https://doaj.org/article/8edce817ae674701824517ad8d322f7e2015-02-01T00:00:00Zhttp://www.dovepress.com/the-emerging-role-of-bexarotene-in-the-treatment-of-alzheimerrsquos-di-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021 Babak Tousi Cleveland Clinic Lou Ruvo Center for Brian Health, Neurological Institute, Cleveland, OH, USA Abstract: In 2012, a novel approach to the treatment of Alzheimer’s disease was introduced, heralding a wave of excitement in the field of dementia. Bexarotene, a retinoid X receptor agonist, was shown to reverse neurodegeneration, improve cognition, and decrease levels of amyloid-ß in transgenic mice expressing familial Alzheimer disease mutations. Since then, there has been widespread discussion about bexarotene, as well as a number of follow-up studies. Bexarotene is a unique compound, as it is approved by the US Food and Drug Administration for other purposes and there are reasonable data to justify its mechanism of action in dementia. This review discusses these studies and the emerging role of bexarotene in the clinical field of Alzheimer’s dementia. Keywords: repurposing, ApoE-targeted mice, amyloid, therapy, dementiaTousi BDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2015, Iss default, Pp 311-315 (2015) |
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DOAJ |
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EN |
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Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 |
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Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Tousi B The emerging role of bexarotene in the treatment of Alzheimer’s disease: current evidence |
| description |
Babak Tousi Cleveland Clinic Lou Ruvo Center for Brian Health, Neurological Institute, Cleveland, OH, USA Abstract: In 2012, a novel approach to the treatment of Alzheimer’s disease was introduced, heralding a wave of excitement in the field of dementia. Bexarotene, a retinoid X receptor agonist, was shown to reverse neurodegeneration, improve cognition, and decrease levels of amyloid-ß in transgenic mice expressing familial Alzheimer disease mutations. Since then, there has been widespread discussion about bexarotene, as well as a number of follow-up studies. Bexarotene is a unique compound, as it is approved by the US Food and Drug Administration for other purposes and there are reasonable data to justify its mechanism of action in dementia. This review discusses these studies and the emerging role of bexarotene in the clinical field of Alzheimer’s dementia. Keywords: repurposing, ApoE-targeted mice, amyloid, therapy, dementia |
| format |
article |
| author |
Tousi B |
| author_facet |
Tousi B |
| author_sort |
Tousi B |
| title |
The emerging role of bexarotene in the treatment of Alzheimer’s disease: current evidence |
| title_short |
The emerging role of bexarotene in the treatment of Alzheimer’s disease: current evidence |
| title_full |
The emerging role of bexarotene in the treatment of Alzheimer’s disease: current evidence |
| title_fullStr |
The emerging role of bexarotene in the treatment of Alzheimer’s disease: current evidence |
| title_full_unstemmed |
The emerging role of bexarotene in the treatment of Alzheimer’s disease: current evidence |
| title_sort |
emerging role of bexarotene in the treatment of alzheimer’s disease: current evidence |
| publisher |
Dove Medical Press |
| publishDate |
2015 |
| url |
https://doaj.org/article/8edce817ae674701824517ad8d322f7e |
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AT tousib theemergingroleofbexaroteneinthetreatmentofalzheimerrsquosdiseasecurrentevidence AT tousib emergingroleofbexaroteneinthetreatmentofalzheimerrsquosdiseasecurrentevidence |
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