Gender-Related Differences in Chest Pain Syndromes in the Frontiers in CV Medicine Special Issue: Sex & Gender in CV Medicine

Coronary artery disease (CAD) is the leading cause of morbidity and mortality among both women and men, yet women continue to have delays in diagnosis and treatment. The lack of recognition of sex-specific biological and socio-cultural gender-related differences in chest pain presentation of CAD may...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Puja K. Mehta, Janet Wei, Chrisandra Shufelt, Odayme Quesada, Leslee Shaw, C. Noel Bairey Merz
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	sex gender chest pain coronary artery disease INOCA Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/8edf9f7b92194b77b717556c0557f3af
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:8edf9f7b92194b77b717556c0557f3af
record_format	dspace
spelling	oai:doaj.org-article:8edf9f7b92194b77b717556c0557f3af2021-11-17T05:06:44ZGender-Related Differences in Chest Pain Syndromes in the Frontiers in CV Medicine Special Issue: Sex & Gender in CV Medicine2297-055X10.3389/fcvm.2021.744788https://doaj.org/article/8edf9f7b92194b77b717556c0557f3af2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcvm.2021.744788/fullhttps://doaj.org/toc/2297-055XCoronary artery disease (CAD) is the leading cause of morbidity and mortality among both women and men, yet women continue to have delays in diagnosis and treatment. The lack of recognition of sex-specific biological and socio-cultural gender-related differences in chest pain presentation of CAD may, in part, explain these disparities. Sex and gender differences in pain mechanisms including psychological susceptibility, the autonomic nervous system (ANS) reactivity, and visceral innervation likely contribute to chest pain differences. CAD risk scores and typical/atypical angina characterization no longer appear relevant and should not be used in women and men. Women more often have ischemia with no obstructive CAD (INOCA) and myocardial infarction, contributing to diagnostic and therapeutic equipoise. Existing knowledge demonstrates that chest pain often does not relate to obstructive CAD, suggesting a more thoughtful approach to percutaneous coronary intervention (PCI) and medical therapy for chest pain in stable obstructive CAD. Emerging knowledge regarding the central and ANS and visceral pain processing in patients with and without angina offers explanatory mechanisms for chest pain and should be investigated with interdisciplinary teams of cardiologists, neuroscientists, bio-behavioral experts, and pain specialists. Improved understanding of sex and gender differences in chest pain, including biological pathways as well as sociocultural contributions, is needed to improve clinical care in both women and men.Puja K. MehtaJanet WeiChrisandra ShufeltOdayme QuesadaLeslee ShawC. Noel Bairey MerzFrontiers Media S.A.articlesexgenderchest paincoronary artery diseaseINOCADiseases of the circulatory (Cardiovascular) systemRC666-701ENFrontiers in Cardiovascular Medicine, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	sex gender chest pain coronary artery disease INOCA Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	sex gender chest pain coronary artery disease INOCA Diseases of the circulatory (Cardiovascular) system RC666-701 Puja K. Mehta Janet Wei Chrisandra Shufelt Odayme Quesada Leslee Shaw C. Noel Bairey Merz Gender-Related Differences in Chest Pain Syndromes in the Frontiers in CV Medicine Special Issue: Sex & Gender in CV Medicine
description	Coronary artery disease (CAD) is the leading cause of morbidity and mortality among both women and men, yet women continue to have delays in diagnosis and treatment. The lack of recognition of sex-specific biological and socio-cultural gender-related differences in chest pain presentation of CAD may, in part, explain these disparities. Sex and gender differences in pain mechanisms including psychological susceptibility, the autonomic nervous system (ANS) reactivity, and visceral innervation likely contribute to chest pain differences. CAD risk scores and typical/atypical angina characterization no longer appear relevant and should not be used in women and men. Women more often have ischemia with no obstructive CAD (INOCA) and myocardial infarction, contributing to diagnostic and therapeutic equipoise. Existing knowledge demonstrates that chest pain often does not relate to obstructive CAD, suggesting a more thoughtful approach to percutaneous coronary intervention (PCI) and medical therapy for chest pain in stable obstructive CAD. Emerging knowledge regarding the central and ANS and visceral pain processing in patients with and without angina offers explanatory mechanisms for chest pain and should be investigated with interdisciplinary teams of cardiologists, neuroscientists, bio-behavioral experts, and pain specialists. Improved understanding of sex and gender differences in chest pain, including biological pathways as well as sociocultural contributions, is needed to improve clinical care in both women and men.
format	article
author	Puja K. Mehta Janet Wei Chrisandra Shufelt Odayme Quesada Leslee Shaw C. Noel Bairey Merz
author_facet	Puja K. Mehta Janet Wei Chrisandra Shufelt Odayme Quesada Leslee Shaw C. Noel Bairey Merz
author_sort	Puja K. Mehta
title	Gender-Related Differences in Chest Pain Syndromes in the Frontiers in CV Medicine Special Issue: Sex & Gender in CV Medicine
title_short	Gender-Related Differences in Chest Pain Syndromes in the Frontiers in CV Medicine Special Issue: Sex & Gender in CV Medicine
title_full	Gender-Related Differences in Chest Pain Syndromes in the Frontiers in CV Medicine Special Issue: Sex & Gender in CV Medicine
title_fullStr	Gender-Related Differences in Chest Pain Syndromes in the Frontiers in CV Medicine Special Issue: Sex & Gender in CV Medicine
title_full_unstemmed	Gender-Related Differences in Chest Pain Syndromes in the Frontiers in CV Medicine Special Issue: Sex & Gender in CV Medicine
title_sort	gender-related differences in chest pain syndromes in the frontiers in cv medicine special issue: sex & gender in cv medicine
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/8edf9f7b92194b77b717556c0557f3af
work_keys_str_mv	AT pujakmehta genderrelateddifferencesinchestpainsyndromesinthefrontiersincvmedicinespecialissuesexgenderincvmedicine AT janetwei genderrelateddifferencesinchestpainsyndromesinthefrontiersincvmedicinespecialissuesexgenderincvmedicine AT chrisandrashufelt genderrelateddifferencesinchestpainsyndromesinthefrontiersincvmedicinespecialissuesexgenderincvmedicine AT odaymequesada genderrelateddifferencesinchestpainsyndromesinthefrontiersincvmedicinespecialissuesexgenderincvmedicine AT lesleeshaw genderrelateddifferencesinchestpainsyndromesinthefrontiersincvmedicinespecialissuesexgenderincvmedicine AT cnoelbaireymerz genderrelateddifferencesinchestpainsyndromesinthefrontiersincvmedicinespecialissuesexgenderincvmedicine
_version_	1718425939440828416

Gender-Related Differences in Chest Pain Syndromes in the Frontiers in CV Medicine Special Issue: Sex & Gender in CV Medicine

Ejemplares similares