Psychophysiological Effects of <i>Lactobacillus plantarum</i> PS128 in Patients with Major Depressive Disorder: A Preliminary 8-Week Open Trial

Recent studies have suggested that gut–brain axis may be one of the mechanisms of major depression disorder (MDD). The current study aimed to investigate the effects of <i>Lactobacillus plantarum PS128</i> (PS128) on psychophysiology in patients with MDD. We recruited 11 patients with MD...

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Autores principales:	Hui-Mei Chen, Po-Hsiu Kuo, Chia-Yueh Hsu, Yi-Hung Chiu, Yen-Wenn Liu, Mong-Liang Lu, Chun-Hsin Chen
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	probiotics major depressive disorder inflammation gut permeability microbiota Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/8ee052158ee443f5aa0738a9196424a2
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spelling	oai:doaj.org-article:8ee052158ee443f5aa0738a9196424a22021-11-25T18:33:34ZPsychophysiological Effects of <i>Lactobacillus plantarum</i> PS128 in Patients with Major Depressive Disorder: A Preliminary 8-Week Open Trial10.3390/nu131137312072-6643https://doaj.org/article/8ee052158ee443f5aa0738a9196424a22021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/3731https://doaj.org/toc/2072-6643Recent studies have suggested that gut–brain axis may be one of the mechanisms of major depression disorder (MDD). The current study aimed to investigate the effects of <i>Lactobacillus plantarum PS128</i> (PS128) on psychophysiology in patients with MDD. We recruited 11 patients with MDD and gave them PS128 for 8 weeks. We compared depression symptoms, serum markers of inflammation and gut permeability, and gut microbiota before and after 8-week intervention and also explored the correlations among symptoms, biomarkers, and gut microbiota. After 8-week PS128 intervention, scores of Hamilton Depression Rating Scale-17 and Depression and Somatic symptoms Scale significantly decreased. Serum levels of high sensitivity c-reactive protein, interluekin-6, and tumor necrosis factor-α, zonulin and intestinal fatty acid binding protein, and the composition of gut microbiota did not significantly change after 8-week PS128 intervention. However, we found changes of some genera were correlated with changes of symptoms and biomarkers. In conclusion, this is an open trial with small sample size and has several limitations. The results need to be verified by randomized, double-blind, placebo-controlled trial with larger sample size.Hui-Mei ChenPo-Hsiu KuoChia-Yueh HsuYi-Hung ChiuYen-Wenn LiuMong-Liang LuChun-Hsin ChenMDPI AGarticleprobioticsmajor depressive disorderinflammationgut permeabilitymicrobiotaNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 3731, p 3731 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	probiotics major depressive disorder inflammation gut permeability microbiota Nutrition. Foods and food supply TX341-641
spellingShingle	probiotics major depressive disorder inflammation gut permeability microbiota Nutrition. Foods and food supply TX341-641 Hui-Mei Chen Po-Hsiu Kuo Chia-Yueh Hsu Yi-Hung Chiu Yen-Wenn Liu Mong-Liang Lu Chun-Hsin Chen Psychophysiological Effects of <i>Lactobacillus plantarum</i> PS128 in Patients with Major Depressive Disorder: A Preliminary 8-Week Open Trial
description	Recent studies have suggested that gut–brain axis may be one of the mechanisms of major depression disorder (MDD). The current study aimed to investigate the effects of <i>Lactobacillus plantarum PS128</i> (PS128) on psychophysiology in patients with MDD. We recruited 11 patients with MDD and gave them PS128 for 8 weeks. We compared depression symptoms, serum markers of inflammation and gut permeability, and gut microbiota before and after 8-week intervention and also explored the correlations among symptoms, biomarkers, and gut microbiota. After 8-week PS128 intervention, scores of Hamilton Depression Rating Scale-17 and Depression and Somatic symptoms Scale significantly decreased. Serum levels of high sensitivity c-reactive protein, interluekin-6, and tumor necrosis factor-α, zonulin and intestinal fatty acid binding protein, and the composition of gut microbiota did not significantly change after 8-week PS128 intervention. However, we found changes of some genera were correlated with changes of symptoms and biomarkers. In conclusion, this is an open trial with small sample size and has several limitations. The results need to be verified by randomized, double-blind, placebo-controlled trial with larger sample size.
format	article
author	Hui-Mei Chen Po-Hsiu Kuo Chia-Yueh Hsu Yi-Hung Chiu Yen-Wenn Liu Mong-Liang Lu Chun-Hsin Chen
author_facet	Hui-Mei Chen Po-Hsiu Kuo Chia-Yueh Hsu Yi-Hung Chiu Yen-Wenn Liu Mong-Liang Lu Chun-Hsin Chen
author_sort	Hui-Mei Chen
title	Psychophysiological Effects of <i>Lactobacillus plantarum</i> PS128 in Patients with Major Depressive Disorder: A Preliminary 8-Week Open Trial
title_short	Psychophysiological Effects of <i>Lactobacillus plantarum</i> PS128 in Patients with Major Depressive Disorder: A Preliminary 8-Week Open Trial
title_full	Psychophysiological Effects of <i>Lactobacillus plantarum</i> PS128 in Patients with Major Depressive Disorder: A Preliminary 8-Week Open Trial
title_fullStr	Psychophysiological Effects of <i>Lactobacillus plantarum</i> PS128 in Patients with Major Depressive Disorder: A Preliminary 8-Week Open Trial
title_full_unstemmed	Psychophysiological Effects of <i>Lactobacillus plantarum</i> PS128 in Patients with Major Depressive Disorder: A Preliminary 8-Week Open Trial
title_sort	psychophysiological effects of <i>lactobacillus plantarum</i> ps128 in patients with major depressive disorder: a preliminary 8-week open trial
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/8ee052158ee443f5aa0738a9196424a2
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Psychophysiological Effects of <i>Lactobacillus plantarum</i> PS128 in Patients with Major Depressive Disorder: A Preliminary 8-Week Open Trial

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