Significance of mast cell distribution in placental tissue and membranes in spontaneous preterm birth

Kate Needham,1 Mitali Fadia,2,3 Jane E Dahlstrom,2,3 Kirsti Harrington,2,3 Bruce Shadbolt,4 Stephen J Robson,1,3,51Department of Obstetrics and Gynaecology, Centenary Hospital for Women and Children, Canberra Hospital, Garran, ACT, Australia; 2Department of Anatomical Pathology, ACT Pathology, Canbe...

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Autores principales:	Needham K, Fadia M, Dahlstrom JE, Harrington K, Shadbolt B, Robson SJ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Preterm birth mast cells inflammation cohort study regression modelling Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/8ee16d0f70b84ff7abb433be3b4813b2
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spelling	oai:doaj.org-article:8ee16d0f70b84ff7abb433be3b4813b22021-12-02T03:26:20ZSignificance of mast cell distribution in placental tissue and membranes in spontaneous preterm birth1178-7031https://doaj.org/article/8ee16d0f70b84ff7abb433be3b4813b22016-07-01T00:00:00Zhttps://www.dovepress.com/significance-of-mast-cell-distribution-in-placental-tissue-and-membran-peer-reviewed-article-JIRhttps://doaj.org/toc/1178-7031Kate Needham,1 Mitali Fadia,2,3 Jane E Dahlstrom,2,3 Kirsti Harrington,2,3 Bruce Shadbolt,4 Stephen J Robson,1,3,51Department of Obstetrics and Gynaecology, Centenary Hospital for Women and Children, Canberra Hospital, Garran, ACT, Australia; 2Department of Anatomical Pathology, ACT Pathology, Canberra Hospital, Garran, ACT, Australia; 3ANU Medical School, Australian National University, Canberra, ACT, Australia; 4Department of Epidemiology and Population Health, Canberra Hospital, Garran, ACT, Australia; 5John James Medical Centre, Deakin, ACT, Australia Background: Preterm birth is a common cause of adverse neonatal and childhood outcomes, in both the short and long term. Preterm labor is commonly associated with inflammation at the maternal–fetal interface. There is some indirect evidence that mast cells (MCs) might represent a link between hormonal influences and local reactions leading to the onset of labor. Patients and methods: The placentas and membranes of 51 uncomplicated spontaneous term births were compared to those from 50 spontaneous preterm births. Immunohistochemical staining for MC tryptase was undertaken allowing MC concentration, location, and degranulation status to be determined. Regression modeling was used to compare results. Results: There were no significant differences in the demographic characteristics of the two cohorts. There were significantly more MCs in the decidua for term births than preterm births (P=0.03). The presence of histological chorioamnionitis did not affect MC concentrations. Conclusion: Despite evidence suggesting a possible role for MCs in spontaneous preterm birth, this study found that the concentration of decidual MCs was in fact significantly lower in preterm compared to term birth. Keywords: preterm birth, mast cells, inflammation, cohort study, regression modelingNeedham KFadia MDahlstrom JEHarrington KShadbolt BRobson SJDove Medical PressarticlePreterm birthmast cellsinflammationcohort studyregression modellingPathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol 2016, Iss Issue 1, Pp 141-145 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Preterm birth mast cells inflammation cohort study regression modelling Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	Preterm birth mast cells inflammation cohort study regression modelling Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Needham K Fadia M Dahlstrom JE Harrington K Shadbolt B Robson SJ Significance of mast cell distribution in placental tissue and membranes in spontaneous preterm birth
description	Kate Needham,1 Mitali Fadia,2,3 Jane E Dahlstrom,2,3 Kirsti Harrington,2,3 Bruce Shadbolt,4 Stephen J Robson,1,3,51Department of Obstetrics and Gynaecology, Centenary Hospital for Women and Children, Canberra Hospital, Garran, ACT, Australia; 2Department of Anatomical Pathology, ACT Pathology, Canberra Hospital, Garran, ACT, Australia; 3ANU Medical School, Australian National University, Canberra, ACT, Australia; 4Department of Epidemiology and Population Health, Canberra Hospital, Garran, ACT, Australia; 5John James Medical Centre, Deakin, ACT, Australia Background: Preterm birth is a common cause of adverse neonatal and childhood outcomes, in both the short and long term. Preterm labor is commonly associated with inflammation at the maternal–fetal interface. There is some indirect evidence that mast cells (MCs) might represent a link between hormonal influences and local reactions leading to the onset of labor. Patients and methods: The placentas and membranes of 51 uncomplicated spontaneous term births were compared to those from 50 spontaneous preterm births. Immunohistochemical staining for MC tryptase was undertaken allowing MC concentration, location, and degranulation status to be determined. Regression modeling was used to compare results. Results: There were no significant differences in the demographic characteristics of the two cohorts. There were significantly more MCs in the decidua for term births than preterm births (P=0.03). The presence of histological chorioamnionitis did not affect MC concentrations. Conclusion: Despite evidence suggesting a possible role for MCs in spontaneous preterm birth, this study found that the concentration of decidual MCs was in fact significantly lower in preterm compared to term birth. Keywords: preterm birth, mast cells, inflammation, cohort study, regression modeling
format	article
author	Needham K Fadia M Dahlstrom JE Harrington K Shadbolt B Robson SJ
author_facet	Needham K Fadia M Dahlstrom JE Harrington K Shadbolt B Robson SJ
author_sort	Needham K
title	Significance of mast cell distribution in placental tissue and membranes in spontaneous preterm birth
title_short	Significance of mast cell distribution in placental tissue and membranes in spontaneous preterm birth
title_full	Significance of mast cell distribution in placental tissue and membranes in spontaneous preterm birth
title_fullStr	Significance of mast cell distribution in placental tissue and membranes in spontaneous preterm birth
title_full_unstemmed	Significance of mast cell distribution in placental tissue and membranes in spontaneous preterm birth
title_sort	significance of mast cell distribution in placental tissue and membranes in spontaneous preterm birth
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/8ee16d0f70b84ff7abb433be3b4813b2
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_version_	1718401743369273344

Significance of mast cell distribution in placental tissue and membranes in spontaneous preterm birth

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