Baseline-dependent effects of amphetamine on attention are associated with striatal dopamine metabolism

Abstract Psychostimulants, such as amphetamine, are widely used to treat attentional deficits. In humans, response to dopaminergic medications is complex with improvement often dependent on baseline performance. Our goal was to determine if attention in rats could be improved by low dose amphetamine...

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Autores principales:	Karly M. Turner, James Peak, Thomas H. J. Burne
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8ee3c78937ef44f380741d17cb7841f6
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spelling	oai:doaj.org-article:8ee3c78937ef44f380741d17cb7841f62021-12-02T15:06:13ZBaseline-dependent effects of amphetamine on attention are associated with striatal dopamine metabolism10.1038/s41598-017-00437-92045-2322https://doaj.org/article/8ee3c78937ef44f380741d17cb7841f62017-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00437-9https://doaj.org/toc/2045-2322Abstract Psychostimulants, such as amphetamine, are widely used to treat attentional deficits. In humans, response to dopaminergic medications is complex with improvement often dependent on baseline performance. Our goal was to determine if attention in rats could be improved by low dose amphetamine in a baseline-dependent manner by examining the relationship between task performance, drug response and monoamine levels in corticostriatal tissue. Firstly, rats performed a signal detection task with varying signal durations before administration of saline, 0.1 or 0.25 mg/kg amphetamine. Following 0.1 mg/kg amphetamine, accuracy in poor performing individuals increased to that of high performing rats. Furthermore, baseline accuracy correlated with the magnitude of improvement after amphetamine. Secondly, neurochemical analysis of monoamine content and gene expression levels in the prefrontal cortex (PFC) and dorsal striatum (CPU) was conducted. CPU homovanillic acid and 5-hydroxyindoleacetic acid levels were increased in poor performers with a significant correlation between the expression of the dopamine transporter gene and baseline accuracy. No changes were found in the PFC. These results indicated poor performance was associated with greater response to amphetamine and altered DA and 5-HT neurotransmitter systems in CPU. These results suggest striatal monoamine function may be fundamental to explaining individual differences in psychostimulant response.Karly M. TurnerJames PeakThomas H. J. BurneNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Karly M. Turner James Peak Thomas H. J. Burne Baseline-dependent effects of amphetamine on attention are associated with striatal dopamine metabolism
description	Abstract Psychostimulants, such as amphetamine, are widely used to treat attentional deficits. In humans, response to dopaminergic medications is complex with improvement often dependent on baseline performance. Our goal was to determine if attention in rats could be improved by low dose amphetamine in a baseline-dependent manner by examining the relationship between task performance, drug response and monoamine levels in corticostriatal tissue. Firstly, rats performed a signal detection task with varying signal durations before administration of saline, 0.1 or 0.25 mg/kg amphetamine. Following 0.1 mg/kg amphetamine, accuracy in poor performing individuals increased to that of high performing rats. Furthermore, baseline accuracy correlated with the magnitude of improvement after amphetamine. Secondly, neurochemical analysis of monoamine content and gene expression levels in the prefrontal cortex (PFC) and dorsal striatum (CPU) was conducted. CPU homovanillic acid and 5-hydroxyindoleacetic acid levels were increased in poor performers with a significant correlation between the expression of the dopamine transporter gene and baseline accuracy. No changes were found in the PFC. These results indicated poor performance was associated with greater response to amphetamine and altered DA and 5-HT neurotransmitter systems in CPU. These results suggest striatal monoamine function may be fundamental to explaining individual differences in psychostimulant response.
format	article
author	Karly M. Turner James Peak Thomas H. J. Burne
author_facet	Karly M. Turner James Peak Thomas H. J. Burne
author_sort	Karly M. Turner
title	Baseline-dependent effects of amphetamine on attention are associated with striatal dopamine metabolism
title_short	Baseline-dependent effects of amphetamine on attention are associated with striatal dopamine metabolism
title_full	Baseline-dependent effects of amphetamine on attention are associated with striatal dopamine metabolism
title_fullStr	Baseline-dependent effects of amphetamine on attention are associated with striatal dopamine metabolism
title_full_unstemmed	Baseline-dependent effects of amphetamine on attention are associated with striatal dopamine metabolism
title_sort	baseline-dependent effects of amphetamine on attention are associated with striatal dopamine metabolism
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/8ee3c78937ef44f380741d17cb7841f6
work_keys_str_mv	AT karlymturner baselinedependenteffectsofamphetamineonattentionareassociatedwithstriataldopaminemetabolism AT jamespeak baselinedependenteffectsofamphetamineonattentionareassociatedwithstriataldopaminemetabolism AT thomashjburne baselinedependenteffectsofamphetamineonattentionareassociatedwithstriataldopaminemetabolism
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Baseline-dependent effects of amphetamine on attention are associated with striatal dopamine metabolism

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