Emergence of a novel recombinant of CV-A5 in HFMD epidemics in Xiangyang, China

Abstract Background Hand, foot and mouth disease (HFMD) is caused by a variety of enterovirus serotypes and the etiological spectrum worldwide has changed since a large scale of outbreaks occurred in 1997. Methods A large number of clinical specimens of HFMD patients were collected in Xiangyang and...

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Autores principales:	Yuting Yu, Zhiyu Luo, Weiping Jin, Jianyi Mai, Shasha Qian, Jia Lu, Zhenni Wei, Shengli Meng, Zejun Wang, Xuhua Guan, Yeqing Tong, Shuo Shen
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Coxsakievirus A5 Recombinantion Hand, foot and mouse disease Internal medicine RC31-1245 Genetics QH426-470
Acceso en línea:	https://doaj.org/article/8ee8c9f1c6f1457bb34789f64799512b
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spelling	oai:doaj.org-article:8ee8c9f1c6f1457bb34789f64799512b2021-11-28T12:06:01ZEmergence of a novel recombinant of CV-A5 in HFMD epidemics in Xiangyang, China10.1186/s12920-021-01107-61755-8794https://doaj.org/article/8ee8c9f1c6f1457bb34789f64799512b2021-11-01T00:00:00Zhttps://doi.org/10.1186/s12920-021-01107-6https://doaj.org/toc/1755-8794Abstract Background Hand, foot and mouth disease (HFMD) is caused by a variety of enterovirus serotypes and the etiological spectrum worldwide has changed since a large scale of outbreaks occurred in 1997. Methods A large number of clinical specimens of HFMD patients were collected in Xiangyang and genotyping was performed by qRT-PCR, conventional PCR amplification and sequencing. Among the 146 CV-A5 detected cases, the complete genome sequences of representative strains were determined for genotyping and for recombination analysis. Results It was found that CV-A5 was one of the six major serotypes that caused the epidemic from October 2016 to December 2017. Phylogenetic analyses based on the VP1 sequences showed that these CV-A5 belonged to the genotype D which dominantly circulated in China. Recombination occurred between the CV-A5 and CV-A2 strains with a breakpoint in the 2A region at the nucleotide 3791. Conclusions The result may explain the emergence of CV-A5 as one of the major pathogens of HFMD. A multivalent vaccine against HFMD is urgently needed to control the disease and to prevent emerging and spreading of new recombinants.Yuting YuZhiyu LuoWeiping JinJianyi MaiShasha QianJia LuZhenni WeiShengli MengZejun WangXuhua GuanYeqing TongShuo ShenBMCarticleCoxsakievirus A5RecombinantionHand, foot and mouse diseaseInternal medicineRC31-1245GeneticsQH426-470ENBMC Medical Genomics, Vol 14, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Coxsakievirus A5 Recombinantion Hand, foot and mouse disease Internal medicine RC31-1245 Genetics QH426-470
spellingShingle	Coxsakievirus A5 Recombinantion Hand, foot and mouse disease Internal medicine RC31-1245 Genetics QH426-470 Yuting Yu Zhiyu Luo Weiping Jin Jianyi Mai Shasha Qian Jia Lu Zhenni Wei Shengli Meng Zejun Wang Xuhua Guan Yeqing Tong Shuo Shen Emergence of a novel recombinant of CV-A5 in HFMD epidemics in Xiangyang, China
description	Abstract Background Hand, foot and mouth disease (HFMD) is caused by a variety of enterovirus serotypes and the etiological spectrum worldwide has changed since a large scale of outbreaks occurred in 1997. Methods A large number of clinical specimens of HFMD patients were collected in Xiangyang and genotyping was performed by qRT-PCR, conventional PCR amplification and sequencing. Among the 146 CV-A5 detected cases, the complete genome sequences of representative strains were determined for genotyping and for recombination analysis. Results It was found that CV-A5 was one of the six major serotypes that caused the epidemic from October 2016 to December 2017. Phylogenetic analyses based on the VP1 sequences showed that these CV-A5 belonged to the genotype D which dominantly circulated in China. Recombination occurred between the CV-A5 and CV-A2 strains with a breakpoint in the 2A region at the nucleotide 3791. Conclusions The result may explain the emergence of CV-A5 as one of the major pathogens of HFMD. A multivalent vaccine against HFMD is urgently needed to control the disease and to prevent emerging and spreading of new recombinants.
format	article
author	Yuting Yu Zhiyu Luo Weiping Jin Jianyi Mai Shasha Qian Jia Lu Zhenni Wei Shengli Meng Zejun Wang Xuhua Guan Yeqing Tong Shuo Shen
author_facet	Yuting Yu Zhiyu Luo Weiping Jin Jianyi Mai Shasha Qian Jia Lu Zhenni Wei Shengli Meng Zejun Wang Xuhua Guan Yeqing Tong Shuo Shen
author_sort	Yuting Yu
title	Emergence of a novel recombinant of CV-A5 in HFMD epidemics in Xiangyang, China
title_short	Emergence of a novel recombinant of CV-A5 in HFMD epidemics in Xiangyang, China
title_full	Emergence of a novel recombinant of CV-A5 in HFMD epidemics in Xiangyang, China
title_fullStr	Emergence of a novel recombinant of CV-A5 in HFMD epidemics in Xiangyang, China
title_full_unstemmed	Emergence of a novel recombinant of CV-A5 in HFMD epidemics in Xiangyang, China
title_sort	emergence of a novel recombinant of cv-a5 in hfmd epidemics in xiangyang, china
publisher	BMC
publishDate	2021
url	https://doaj.org/article/8ee8c9f1c6f1457bb34789f64799512b
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Emergence of a novel recombinant of CV-A5 in HFMD epidemics in Xiangyang, China

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