Ginkgo biloba Extract 50 (GBE50) Ameliorates Insulin Resistance, Hepatic Steatosis and Liver Injury in High Fat Diet-Fed Mice

Liu Li,1,* Li Yang,1,* Feng Yang,2,* Xin-lan Zhao,1 Shengjiang Xue,3 Fang-hua Gong4 1No.2 Department of Endocrinology, Hunan Provincial People’s Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, 410002, People’s Republic of China; 2No.2 Department of P...

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Autores principales:	Li L, Yang L, Yang F, Zhao XL, Xue SJ, Gong FH
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	ginkgo biloba extract 50 non-alcoholic fatty liver disease insulin resistance hepatic steatosis inflammatory response liver injury Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/8eea33d965d144f4b0ffb4391f53e9ce
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spelling	oai:doaj.org-article:8eea33d965d144f4b0ffb4391f53e9ce2021-12-02T15:55:49ZGinkgo biloba Extract 50 (GBE50) Ameliorates Insulin Resistance, Hepatic Steatosis and Liver Injury in High Fat Diet-Fed Mice1178-7031https://doaj.org/article/8eea33d965d144f4b0ffb4391f53e9ce2021-05-01T00:00:00Zhttps://www.dovepress.com/ginkgo-biloba-extract-50-gbe50-ameliorates-insulin-resistance-hepatic--peer-reviewed-fulltext-article-JIRhttps://doaj.org/toc/1178-7031Liu Li,1,* Li Yang,1,* Feng Yang,2,* Xin-lan Zhao,1 Shengjiang Xue,3 Fang-hua Gong4 1No.2 Department of Endocrinology, Hunan Provincial People’s Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, 410002, People’s Republic of China; 2No.2 Department of Pharmacy, Hunan Provincial People’s Hospital, the First Affiliated Hospital of Hunan Normal University, Changsha, 410002, People’s Republic of China; 3Ladder Molecular Biomedical Research Center, Guangzhou, 510800, People’s Republic of China; 4Department of Nursing, Hunan Provincial People’s Hospital, the First Affiliated Hospital of Hunan Normal University, Changsha, 410002, People’s Republic of China*These authors contributed equally to this workCorrespondence: Shengjiang XueLadder Molecular Biomedical Research Center, No. 39 Zhanqian Road, Xinhua Street, Huadu District, Guangzhou, 510800, People’s Republic of ChinaEmail wsjiangzi@126.comFang-hua GongDepartment of Nursing, Hunan Provincial People’s Hospital, the First Affiliated Hospital of Hunan Normal University, No. 61 Jiefangxi Road, Furong District, Changsha, 410002, Hunan Province, People’s Republic of ChinaTel +86 0731-84762691Fax +86 0731-8329065Email gfhnurse@aliyun.comBackground: Ginkgo biloba extract 50 (GBE50) has a variety of pharmacological functions such as anti-inflammatory, antioxidant and maintenance of glucose and lipid metabolism homeostasis. However, the therapeutic effects and mechanisms of GBE50 on non-alcoholic fatty liver disease (NAFLD) remain unknown. Therefore, in this study, we evaluated the therapeutic effects of GBE50 in NAFLD by using a high-fat diet (HFD) mice model.Methods: C57BL/6J mice were fed a HFD diet for 15 weeks and were given respectively 25, 50, and 100 mg/kg GBE50 daily by gavage from 3 to 15 weeks. After the administration, blood samples and liver tissues were collected for biochemical detection, histological measurement, immunohistochemistry and Western blot, respectively.Results: We found that GBE50 treatment could ameliorate insulin resistance (IR), glucose intolerance, lipid accumulation, hepatic steatosis and liver injury in HFD-fed mice. Further mechanism exploration discovered that the hepatoprotective effects of GBE50 on NAFLD may be related to the strengthening of IRS-1 signal activation and the weakening of NF-κB, Akt and endoplasmic reticulum stress signals activation.Conclusion: GBE50 is a potentially powerful therapeutic agent for the treatment of NAFLD.Keywords: Ginkgo biloba extract 50, non-alcoholic fatty liver disease, insulin resistance, hepatic steatosis, inflammatory response, liver injuryLi LYang LYang FZhao XLXue SJGong FHDove Medical Pressarticleginkgo biloba extract 50non-alcoholic fatty liver diseaseinsulin resistancehepatic steatosisinflammatory responseliver injuryPathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol Volume 14, Pp 1959-1971 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ginkgo biloba extract 50 non-alcoholic fatty liver disease insulin resistance hepatic steatosis inflammatory response liver injury Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	ginkgo biloba extract 50 non-alcoholic fatty liver disease insulin resistance hepatic steatosis inflammatory response liver injury Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Li L Yang L Yang F Zhao XL Xue SJ Gong FH Ginkgo biloba Extract 50 (GBE50) Ameliorates Insulin Resistance, Hepatic Steatosis and Liver Injury in High Fat Diet-Fed Mice
description	Liu Li,1,* Li Yang,1,* Feng Yang,2,* Xin-lan Zhao,1 Shengjiang Xue,3 Fang-hua Gong4 1No.2 Department of Endocrinology, Hunan Provincial People’s Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, 410002, People’s Republic of China; 2No.2 Department of Pharmacy, Hunan Provincial People’s Hospital, the First Affiliated Hospital of Hunan Normal University, Changsha, 410002, People’s Republic of China; 3Ladder Molecular Biomedical Research Center, Guangzhou, 510800, People’s Republic of China; 4Department of Nursing, Hunan Provincial People’s Hospital, the First Affiliated Hospital of Hunan Normal University, Changsha, 410002, People’s Republic of China*These authors contributed equally to this workCorrespondence: Shengjiang XueLadder Molecular Biomedical Research Center, No. 39 Zhanqian Road, Xinhua Street, Huadu District, Guangzhou, 510800, People’s Republic of ChinaEmail wsjiangzi@126.comFang-hua GongDepartment of Nursing, Hunan Provincial People’s Hospital, the First Affiliated Hospital of Hunan Normal University, No. 61 Jiefangxi Road, Furong District, Changsha, 410002, Hunan Province, People’s Republic of ChinaTel +86 0731-84762691Fax +86 0731-8329065Email gfhnurse@aliyun.comBackground: Ginkgo biloba extract 50 (GBE50) has a variety of pharmacological functions such as anti-inflammatory, antioxidant and maintenance of glucose and lipid metabolism homeostasis. However, the therapeutic effects and mechanisms of GBE50 on non-alcoholic fatty liver disease (NAFLD) remain unknown. Therefore, in this study, we evaluated the therapeutic effects of GBE50 in NAFLD by using a high-fat diet (HFD) mice model.Methods: C57BL/6J mice were fed a HFD diet for 15 weeks and were given respectively 25, 50, and 100 mg/kg GBE50 daily by gavage from 3 to 15 weeks. After the administration, blood samples and liver tissues were collected for biochemical detection, histological measurement, immunohistochemistry and Western blot, respectively.Results: We found that GBE50 treatment could ameliorate insulin resistance (IR), glucose intolerance, lipid accumulation, hepatic steatosis and liver injury in HFD-fed mice. Further mechanism exploration discovered that the hepatoprotective effects of GBE50 on NAFLD may be related to the strengthening of IRS-1 signal activation and the weakening of NF-κB, Akt and endoplasmic reticulum stress signals activation.Conclusion: GBE50 is a potentially powerful therapeutic agent for the treatment of NAFLD.Keywords: Ginkgo biloba extract 50, non-alcoholic fatty liver disease, insulin resistance, hepatic steatosis, inflammatory response, liver injury
format	article
author	Li L Yang L Yang F Zhao XL Xue SJ Gong FH
author_facet	Li L Yang L Yang F Zhao XL Xue SJ Gong FH
author_sort	Li L
title	Ginkgo biloba Extract 50 (GBE50) Ameliorates Insulin Resistance, Hepatic Steatosis and Liver Injury in High Fat Diet-Fed Mice
title_short	Ginkgo biloba Extract 50 (GBE50) Ameliorates Insulin Resistance, Hepatic Steatosis and Liver Injury in High Fat Diet-Fed Mice
title_full	Ginkgo biloba Extract 50 (GBE50) Ameliorates Insulin Resistance, Hepatic Steatosis and Liver Injury in High Fat Diet-Fed Mice
title_fullStr	Ginkgo biloba Extract 50 (GBE50) Ameliorates Insulin Resistance, Hepatic Steatosis and Liver Injury in High Fat Diet-Fed Mice
title_full_unstemmed	Ginkgo biloba Extract 50 (GBE50) Ameliorates Insulin Resistance, Hepatic Steatosis and Liver Injury in High Fat Diet-Fed Mice
title_sort	ginkgo biloba extract 50 (gbe50) ameliorates insulin resistance, hepatic steatosis and liver injury in high fat diet-fed mice
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/8eea33d965d144f4b0ffb4391f53e9ce
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Ginkgo biloba Extract 50 (GBE50) Ameliorates Insulin Resistance, Hepatic Steatosis and Liver Injury in High Fat Diet-Fed Mice

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