Hop flower extracts mitigate retinal ganglion cell degeneration in a glaucoma mouse model

Abstract In glaucoma, retinal ganglion cells degenerate progressively, leading to visual field loss and blindness. Presently, the only treatment strategy for glaucoma is lowering the intraocular pressure. However, there are cases in which patients develop progressive visual field loss even though th...

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Auteurs principaux:	Tomoko Hasegawa, Hanako O. Ikeda, Sachiko Iwai, Norio Sasaoka, Akira Kakizuka, Akitaka Tsujikawa
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2020
Sujets:	Medicine R Science Q
Accès en ligne:	https://doaj.org/article/8eeeba1c48204dceb4e036fedf10b1ea
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spelling	oai:doaj.org-article:8eeeba1c48204dceb4e036fedf10b1ea2021-12-02T15:11:52ZHop flower extracts mitigate retinal ganglion cell degeneration in a glaucoma mouse model10.1038/s41598-020-78731-22045-2322https://doaj.org/article/8eeeba1c48204dceb4e036fedf10b1ea2020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-78731-2https://doaj.org/toc/2045-2322Abstract In glaucoma, retinal ganglion cells degenerate progressively, leading to visual field loss and blindness. Presently, the only treatment strategy for glaucoma is lowering the intraocular pressure. However, there are cases in which patients develop progressive visual field loss even though their intraocular pressures are within normal ranges. Therefore, the development of novel therapeutic strategies is an urgent endeavor. Besides high intraocular pressure, several other factors have been proposed to be associated with glaucoma progression, e.g., myopia, blood flow impairment, and amyloid β accumulation. We have previously reported that hop flower extracts possess γ-secretase inhibitory activities and reduce amyloid β deposition in the brains of Alzheimer’s disease model mice. In the current study, we showed that administration of hop flower extracts to glutamate-aspartate transporter (GLAST) knockout mice, the glaucoma model mice, attenuated glaucomatous retinal ganglion cell degeneration. Preservation of retinal ganglion cells in hop flower extract-administered mice was confirmed using optical coherence tomography, confocal scanning laser ophthalmoscopy, and retinal flatmount and histological evaluations. Hop flower extracts are, therefore, deemed a possible candidate as a novel therapeutic agent to treat glaucoma.Tomoko HasegawaHanako O. IkedaSachiko IwaiNorio SasaokaAkira KakizukaAkitaka TsujikawaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tomoko Hasegawa Hanako O. Ikeda Sachiko Iwai Norio Sasaoka Akira Kakizuka Akitaka Tsujikawa Hop flower extracts mitigate retinal ganglion cell degeneration in a glaucoma mouse model
description	Abstract In glaucoma, retinal ganglion cells degenerate progressively, leading to visual field loss and blindness. Presently, the only treatment strategy for glaucoma is lowering the intraocular pressure. However, there are cases in which patients develop progressive visual field loss even though their intraocular pressures are within normal ranges. Therefore, the development of novel therapeutic strategies is an urgent endeavor. Besides high intraocular pressure, several other factors have been proposed to be associated with glaucoma progression, e.g., myopia, blood flow impairment, and amyloid β accumulation. We have previously reported that hop flower extracts possess γ-secretase inhibitory activities and reduce amyloid β deposition in the brains of Alzheimer’s disease model mice. In the current study, we showed that administration of hop flower extracts to glutamate-aspartate transporter (GLAST) knockout mice, the glaucoma model mice, attenuated glaucomatous retinal ganglion cell degeneration. Preservation of retinal ganglion cells in hop flower extract-administered mice was confirmed using optical coherence tomography, confocal scanning laser ophthalmoscopy, and retinal flatmount and histological evaluations. Hop flower extracts are, therefore, deemed a possible candidate as a novel therapeutic agent to treat glaucoma.
format	article
author	Tomoko Hasegawa Hanako O. Ikeda Sachiko Iwai Norio Sasaoka Akira Kakizuka Akitaka Tsujikawa
author_facet	Tomoko Hasegawa Hanako O. Ikeda Sachiko Iwai Norio Sasaoka Akira Kakizuka Akitaka Tsujikawa
author_sort	Tomoko Hasegawa
title	Hop flower extracts mitigate retinal ganglion cell degeneration in a glaucoma mouse model
title_short	Hop flower extracts mitigate retinal ganglion cell degeneration in a glaucoma mouse model
title_full	Hop flower extracts mitigate retinal ganglion cell degeneration in a glaucoma mouse model
title_fullStr	Hop flower extracts mitigate retinal ganglion cell degeneration in a glaucoma mouse model
title_full_unstemmed	Hop flower extracts mitigate retinal ganglion cell degeneration in a glaucoma mouse model
title_sort	hop flower extracts mitigate retinal ganglion cell degeneration in a glaucoma mouse model
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/8eeeba1c48204dceb4e036fedf10b1ea
work_keys_str_mv	AT tomokohasegawa hopflowerextractsmitigateretinalganglioncelldegenerationinaglaucomamousemodel AT hanakooikeda hopflowerextractsmitigateretinalganglioncelldegenerationinaglaucomamousemodel AT sachikoiwai hopflowerextractsmitigateretinalganglioncelldegenerationinaglaucomamousemodel AT noriosasaoka hopflowerextractsmitigateretinalganglioncelldegenerationinaglaucomamousemodel AT akirakakizuka hopflowerextractsmitigateretinalganglioncelldegenerationinaglaucomamousemodel AT akitakatsujikawa hopflowerextractsmitigateretinalganglioncelldegenerationinaglaucomamousemodel
_version_	1718387643930116096

Hop flower extracts mitigate retinal ganglion cell degeneration in a glaucoma mouse model

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