The influence of Propylene glycol/Water and Ethanol/Water Binary Solvents on the in vitro Permeation of Garcinia mangostana L. Pericarp Extract across Shed Snakeskin

Garcinia mangostana pericarp (GMP) has antioxidant activity thus may be developed into a topical antioxidant formulation. This research aimed to study the topical delivery of GMP extract. Initially, some commonly used topical solvents, i.e., water and binary solvents of propylene glycol (PG)/water...

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Autores principales:	Rina Kuswahyuning, TN Saifullah Sulaiman, Galuh Wahyu Ananingrum, Rias Reno Andini
Formato:	article
Lenguaje:	EN
Publicado:	Universitas Gadjah Mada 2020
Materias:	garcinia mangostana pericarp extract skin permeation antioxidant dpph scavenging rsgmpe Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/8ef190c304014b91a801965ba73b4a68
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spelling	oai:doaj.org-article:8ef190c304014b91a801965ba73b4a682021-11-15T06:08:47ZThe influence of Propylene glycol/Water and Ethanol/Water Binary Solvents on the in vitro Permeation of Garcinia mangostana L. Pericarp Extract across Shed Snakeskin2338-94272338-948610.22146/ijp.599https://doaj.org/article/8ef190c304014b91a801965ba73b4a682020-08-01T00:00:00Zhttps://jurnal.ugm.ac.id/v3/IJP/article/view/599https://doaj.org/toc/2338-9427https://doaj.org/toc/2338-9486Garcinia mangostana pericarp (GMP) has antioxidant activity thus may be developed into a topical antioxidant formulation. This research aimed to study the topical delivery of GMP extract. Initially, some commonly used topical solvents, i.e., water and binary solvents of propylene glycol (PG)/water and ethanol/water (0; 10; 20 and 40%), were used to dissolve GMP extract and further tested on GMP extract in vitro skin permeation using shed snakeskin. The influence of solvents' effects was evaluated based on radical DPPH scavenging activity and expressed as radical scavenging activity equivalent GMP Extract (RSGMPE). The results showed that RSGMPE could be delivered into shed snakeskin. The extent of RSGMPE shed snakeskin retention was similar among water and all PG/water or ethanol/water binary solvents. RSGMPE was also found in the receptor phase from all PG/water binary solvents, whereas that from ethanol/water solvents only shown from 20% ethanol/water solvent even though all ethanol-water solvents produced significantly higher RSGMPE compared to water and PG/water binary solventsRina KuswahyuningTN Saifullah SulaimanGaluh Wahyu AnaningrumRias Reno AndiniUniversitas Gadjah Madaarticlegarcinia mangostana pericarp extractskin permeationantioxidantdpph scavengingrsgmpePharmacy and materia medicaRS1-441ENIndonesian Journal of Pharmacy, Pp 187-192 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	garcinia mangostana pericarp extract skin permeation antioxidant dpph scavenging rsgmpe Pharmacy and materia medica RS1-441
spellingShingle	garcinia mangostana pericarp extract skin permeation antioxidant dpph scavenging rsgmpe Pharmacy and materia medica RS1-441 Rina Kuswahyuning TN Saifullah Sulaiman Galuh Wahyu Ananingrum Rias Reno Andini The influence of Propylene glycol/Water and Ethanol/Water Binary Solvents on the in vitro Permeation of Garcinia mangostana L. Pericarp Extract across Shed Snakeskin
description	Garcinia mangostana pericarp (GMP) has antioxidant activity thus may be developed into a topical antioxidant formulation. This research aimed to study the topical delivery of GMP extract. Initially, some commonly used topical solvents, i.e., water and binary solvents of propylene glycol (PG)/water and ethanol/water (0; 10; 20 and 40%), were used to dissolve GMP extract and further tested on GMP extract in vitro skin permeation using shed snakeskin. The influence of solvents' effects was evaluated based on radical DPPH scavenging activity and expressed as radical scavenging activity equivalent GMP Extract (RSGMPE). The results showed that RSGMPE could be delivered into shed snakeskin. The extent of RSGMPE shed snakeskin retention was similar among water and all PG/water or ethanol/water binary solvents. RSGMPE was also found in the receptor phase from all PG/water binary solvents, whereas that from ethanol/water solvents only shown from 20% ethanol/water solvent even though all ethanol-water solvents produced significantly higher RSGMPE compared to water and PG/water binary solvents
format	article
author	Rina Kuswahyuning TN Saifullah Sulaiman Galuh Wahyu Ananingrum Rias Reno Andini
author_facet	Rina Kuswahyuning TN Saifullah Sulaiman Galuh Wahyu Ananingrum Rias Reno Andini
author_sort	Rina Kuswahyuning
title	The influence of Propylene glycol/Water and Ethanol/Water Binary Solvents on the in vitro Permeation of Garcinia mangostana L. Pericarp Extract across Shed Snakeskin
title_short	The influence of Propylene glycol/Water and Ethanol/Water Binary Solvents on the in vitro Permeation of Garcinia mangostana L. Pericarp Extract across Shed Snakeskin
title_full	The influence of Propylene glycol/Water and Ethanol/Water Binary Solvents on the in vitro Permeation of Garcinia mangostana L. Pericarp Extract across Shed Snakeskin
title_fullStr	The influence of Propylene glycol/Water and Ethanol/Water Binary Solvents on the in vitro Permeation of Garcinia mangostana L. Pericarp Extract across Shed Snakeskin
title_full_unstemmed	The influence of Propylene glycol/Water and Ethanol/Water Binary Solvents on the in vitro Permeation of Garcinia mangostana L. Pericarp Extract across Shed Snakeskin
title_sort	influence of propylene glycol/water and ethanol/water binary solvents on the in vitro permeation of garcinia mangostana l. pericarp extract across shed snakeskin
publisher	Universitas Gadjah Mada
publishDate	2020
url	https://doaj.org/article/8ef190c304014b91a801965ba73b4a68
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The influence of Propylene glycol/Water and Ethanol/Water Binary Solvents on the in vitro Permeation of Garcinia mangostana L. Pericarp Extract across Shed Snakeskin

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