A broad spectrum anti-bacterial peptide with an adjunct potential for tuberculosis chemotherapy

Abstract Alternative ways to prevent and treat infectious diseases are needed. Previously, we identified a fungal peptide, NZX, that was comparable to rifampicin in lowering M. tuberculosis load in a murine tuberculosis (TB) infection model. Here we assessed the potential synergy between this cation...

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Autores principales:	Komal Umashankar Rao, Domhnall Iain Henderson, Nitya Krishnan, Manoj Puthia, Izabela Glegola-Madejska, Lena Brive, Fanny Bjarnemark, Anna Millqvist Fureby, Karin Hjort, Dan I. Andersson, Erik Tenland, Erik Sturegård, Brian D. Robertson, Gabriela Godaly
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8ef6d83379c541af9973c901102863f4
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spelling	oai:doaj.org-article:8ef6d83379c541af9973c901102863f42021-12-02T12:11:50ZA broad spectrum anti-bacterial peptide with an adjunct potential for tuberculosis chemotherapy10.1038/s41598-021-83755-32045-2322https://doaj.org/article/8ef6d83379c541af9973c901102863f42021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83755-3https://doaj.org/toc/2045-2322Abstract Alternative ways to prevent and treat infectious diseases are needed. Previously, we identified a fungal peptide, NZX, that was comparable to rifampicin in lowering M. tuberculosis load in a murine tuberculosis (TB) infection model. Here we assessed the potential synergy between this cationic host defence peptide (CHDP) and the current TB drugs and analysed its pharmacokinetics. We found additive effect of this peptide with isoniazid and ethambutol and confirmed these results with ethambutol in a murine TB-model. In vivo, the peptide remained stable in circulation and preserved lung structure better than ethambutol alone. Antibiotic resistance studies did not induce mutants with reduced susceptibility to the peptide. We further observed that this peptide was effective against nontuberculous mycobacteria (NTM), such as M. avium and M. abscessus, and several Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus. In conclusion, the presented data supports a role for this CHDP in the treatment of drug resistant organisms.Komal Umashankar RaoDomhnall Iain HendersonNitya KrishnanManoj PuthiaIzabela Glegola-MadejskaLena BriveFanny BjarnemarkAnna Millqvist FurebyKarin HjortDan I. AnderssonErik TenlandErik SturegårdBrian D. RobertsonGabriela GodalyNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Komal Umashankar Rao Domhnall Iain Henderson Nitya Krishnan Manoj Puthia Izabela Glegola-Madejska Lena Brive Fanny Bjarnemark Anna Millqvist Fureby Karin Hjort Dan I. Andersson Erik Tenland Erik Sturegård Brian D. Robertson Gabriela Godaly A broad spectrum anti-bacterial peptide with an adjunct potential for tuberculosis chemotherapy
description	Abstract Alternative ways to prevent and treat infectious diseases are needed. Previously, we identified a fungal peptide, NZX, that was comparable to rifampicin in lowering M. tuberculosis load in a murine tuberculosis (TB) infection model. Here we assessed the potential synergy between this cationic host defence peptide (CHDP) and the current TB drugs and analysed its pharmacokinetics. We found additive effect of this peptide with isoniazid and ethambutol and confirmed these results with ethambutol in a murine TB-model. In vivo, the peptide remained stable in circulation and preserved lung structure better than ethambutol alone. Antibiotic resistance studies did not induce mutants with reduced susceptibility to the peptide. We further observed that this peptide was effective against nontuberculous mycobacteria (NTM), such as M. avium and M. abscessus, and several Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus. In conclusion, the presented data supports a role for this CHDP in the treatment of drug resistant organisms.
format	article
author	Komal Umashankar Rao Domhnall Iain Henderson Nitya Krishnan Manoj Puthia Izabela Glegola-Madejska Lena Brive Fanny Bjarnemark Anna Millqvist Fureby Karin Hjort Dan I. Andersson Erik Tenland Erik Sturegård Brian D. Robertson Gabriela Godaly
author_facet	Komal Umashankar Rao Domhnall Iain Henderson Nitya Krishnan Manoj Puthia Izabela Glegola-Madejska Lena Brive Fanny Bjarnemark Anna Millqvist Fureby Karin Hjort Dan I. Andersson Erik Tenland Erik Sturegård Brian D. Robertson Gabriela Godaly
author_sort	Komal Umashankar Rao
title	A broad spectrum anti-bacterial peptide with an adjunct potential for tuberculosis chemotherapy
title_short	A broad spectrum anti-bacterial peptide with an adjunct potential for tuberculosis chemotherapy
title_full	A broad spectrum anti-bacterial peptide with an adjunct potential for tuberculosis chemotherapy
title_fullStr	A broad spectrum anti-bacterial peptide with an adjunct potential for tuberculosis chemotherapy
title_full_unstemmed	A broad spectrum anti-bacterial peptide with an adjunct potential for tuberculosis chemotherapy
title_sort	broad spectrum anti-bacterial peptide with an adjunct potential for tuberculosis chemotherapy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8ef6d83379c541af9973c901102863f4
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A broad spectrum anti-bacterial peptide with an adjunct potential for tuberculosis chemotherapy

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