Extracellular LGALS3BP regulates neural progenitor position and relates to human cortical complexity

Basal progenitors are enriched in gyrencephalic species like humans contributing to neuronal expansion. Here the authors show that LGALS3BP de novo variants are related to reduced cortical complexity and area in humans and that LGALS3BP regulates neural progenitor position in organoids, human fetal...

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Autores principales:	Christina Kyrousi, Adam C. O’Neill, Agnieska Brazovskaja, Zhisong He, Pavel Kielkowski, Laure Coquand, Rossella Di Giaimo, Pierpaolo D’ Andrea, Alexander Belka, Andrea Forero Echeverry, Davide Mei, Matteo Lenge, Cristiana Cruceanu, Isabel Y. Buchsbaum, Shahryar Khattak, Guimiot Fabien, Elisabeth Binder, Frances Elmslie, Renzo Guerrini, Alexandre D. Baffet, Stephan A. Sieber, Barbara Treutlein, Stephen P. Robertson, Silvia Cappello
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8ef84fb2a10e47ca9c3467c7a2d8e981
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spelling	oai:doaj.org-article:8ef84fb2a10e47ca9c3467c7a2d8e9812021-11-08T11:05:53ZExtracellular LGALS3BP regulates neural progenitor position and relates to human cortical complexity10.1038/s41467-021-26447-w2041-1723https://doaj.org/article/8ef84fb2a10e47ca9c3467c7a2d8e9812021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26447-whttps://doaj.org/toc/2041-1723Basal progenitors are enriched in gyrencephalic species like humans contributing to neuronal expansion. Here the authors show that LGALS3BP de novo variants are related to reduced cortical complexity and area in humans and that LGALS3BP regulates neural progenitor position in organoids, human fetal tissue and mice.Christina KyrousiAdam C. O’NeillAgnieska BrazovskajaZhisong HePavel KielkowskiLaure CoquandRossella Di GiaimoPierpaolo D’ AndreaAlexander BelkaAndrea Forero EcheverryDavide MeiMatteo LengeCristiana CruceanuIsabel Y. BuchsbaumShahryar KhattakGuimiot FabienElisabeth BinderFrances ElmslieRenzo GuerriniAlexandre D. BaffetStephan A. SieberBarbara TreutleinStephen P. RobertsonSilvia CappelloNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-22 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Christina Kyrousi Adam C. O’Neill Agnieska Brazovskaja Zhisong He Pavel Kielkowski Laure Coquand Rossella Di Giaimo Pierpaolo D’ Andrea Alexander Belka Andrea Forero Echeverry Davide Mei Matteo Lenge Cristiana Cruceanu Isabel Y. Buchsbaum Shahryar Khattak Guimiot Fabien Elisabeth Binder Frances Elmslie Renzo Guerrini Alexandre D. Baffet Stephan A. Sieber Barbara Treutlein Stephen P. Robertson Silvia Cappello Extracellular LGALS3BP regulates neural progenitor position and relates to human cortical complexity
description	Basal progenitors are enriched in gyrencephalic species like humans contributing to neuronal expansion. Here the authors show that LGALS3BP de novo variants are related to reduced cortical complexity and area in humans and that LGALS3BP regulates neural progenitor position in organoids, human fetal tissue and mice.
format	article
author	Christina Kyrousi Adam C. O’Neill Agnieska Brazovskaja Zhisong He Pavel Kielkowski Laure Coquand Rossella Di Giaimo Pierpaolo D’ Andrea Alexander Belka Andrea Forero Echeverry Davide Mei Matteo Lenge Cristiana Cruceanu Isabel Y. Buchsbaum Shahryar Khattak Guimiot Fabien Elisabeth Binder Frances Elmslie Renzo Guerrini Alexandre D. Baffet Stephan A. Sieber Barbara Treutlein Stephen P. Robertson Silvia Cappello
author_facet	Christina Kyrousi Adam C. O’Neill Agnieska Brazovskaja Zhisong He Pavel Kielkowski Laure Coquand Rossella Di Giaimo Pierpaolo D’ Andrea Alexander Belka Andrea Forero Echeverry Davide Mei Matteo Lenge Cristiana Cruceanu Isabel Y. Buchsbaum Shahryar Khattak Guimiot Fabien Elisabeth Binder Frances Elmslie Renzo Guerrini Alexandre D. Baffet Stephan A. Sieber Barbara Treutlein Stephen P. Robertson Silvia Cappello
author_sort	Christina Kyrousi
title	Extracellular LGALS3BP regulates neural progenitor position and relates to human cortical complexity
title_short	Extracellular LGALS3BP regulates neural progenitor position and relates to human cortical complexity
title_full	Extracellular LGALS3BP regulates neural progenitor position and relates to human cortical complexity
title_fullStr	Extracellular LGALS3BP regulates neural progenitor position and relates to human cortical complexity
title_full_unstemmed	Extracellular LGALS3BP regulates neural progenitor position and relates to human cortical complexity
title_sort	extracellular lgals3bp regulates neural progenitor position and relates to human cortical complexity
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8ef84fb2a10e47ca9c3467c7a2d8e981
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Extracellular LGALS3BP regulates neural progenitor position and relates to human cortical complexity

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