Association of Serum Galectin-3-Binding Protein and Metabolic Syndrome in a Chinese Adult Population

BackgroundGalectin-3-binding protein (GAL-3BP) is a ubiquitous and multifunctional secreted glycoprotein, which functions in innate immunity and has been highlighted as a potential mediator of adipose inflammation in obesity. In this study, we aimed to identify whether GAL-3BP is a novel biological...

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Autores principales:	Shihan Zhen, Ruoxin Cai, Xuelian Yang, Yanan Ma, Deliang Wen
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	metabolic syndrome inflammation biomarker sex difference galectin-3-binding protein Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/8efb7ff4a9c648fda1d2d2ed1202c885
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spelling	oai:doaj.org-article:8efb7ff4a9c648fda1d2d2ed1202c8852021-11-10T11:57:01ZAssociation of Serum Galectin-3-Binding Protein and Metabolic Syndrome in a Chinese Adult Population1664-239210.3389/fendo.2021.726154https://doaj.org/article/8efb7ff4a9c648fda1d2d2ed1202c8852021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fendo.2021.726154/fullhttps://doaj.org/toc/1664-2392BackgroundGalectin-3-binding protein (GAL-3BP) is a ubiquitous and multifunctional secreted glycoprotein, which functions in innate immunity and has been highlighted as a potential mediator of adipose inflammation in obesity. In this study, we aimed to identify whether GAL-3BP is a novel biological marker for metabolic syndrome (MetS).MethodsThe biochemical and anthropometric variables of the 570 participants in this study were evaluated using standard procedures. Their serum GAL-3BP levels were measured using enzyme-linked immunosorbent assay (ELISA), while the association between the glycoprotein and MetS was analyzed using multiple logistic regression analyses. Moreover, an experimental MetS model was established. The expression of GAL-3BP in serum and adipose tissue was measured using ELISA and western blotting. Lipid accumulation was determined with the use of immunohistochemistry and immunofluorescent staining.ResultsThe serum GAL-3BP level was found to be positively associated with MetS. The logistic regression analyses demonstrated that participants expressing the upper levels of GAL-3BP were more likely to develop MetS than those expressing less of the glycoprotein (OR = 2.39, 95%CI: 1.49, 3.83). The association between the serum GAL-3BP level and MetS was found preferentially in postmenopausal women (OR = 2.30, 95%CI: 1.31, 4.05). In addition, GAL-3BP was increased in the serum and visceral adipose tissue (VAT) of high fat diet (HFD) mice. Moreover, GAL-3BP was highly expressed in VAT macrophages.ConclusionsThis study confirmed serum GAL-3BP to be positively associated with MetS, highlighting it as a useful biological marker of MetS in Chinese participants.Shihan ZhenRuoxin CaiXuelian YangYanan MaDeliang WenFrontiers Media S.A.articlemetabolic syndromeinflammationbiomarkersex differencegalectin-3-binding proteinDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENFrontiers in Endocrinology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	metabolic syndrome inflammation biomarker sex difference galectin-3-binding protein Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	metabolic syndrome inflammation biomarker sex difference galectin-3-binding protein Diseases of the endocrine glands. Clinical endocrinology RC648-665 Shihan Zhen Ruoxin Cai Xuelian Yang Yanan Ma Deliang Wen Association of Serum Galectin-3-Binding Protein and Metabolic Syndrome in a Chinese Adult Population
description	BackgroundGalectin-3-binding protein (GAL-3BP) is a ubiquitous and multifunctional secreted glycoprotein, which functions in innate immunity and has been highlighted as a potential mediator of adipose inflammation in obesity. In this study, we aimed to identify whether GAL-3BP is a novel biological marker for metabolic syndrome (MetS).MethodsThe biochemical and anthropometric variables of the 570 participants in this study were evaluated using standard procedures. Their serum GAL-3BP levels were measured using enzyme-linked immunosorbent assay (ELISA), while the association between the glycoprotein and MetS was analyzed using multiple logistic regression analyses. Moreover, an experimental MetS model was established. The expression of GAL-3BP in serum and adipose tissue was measured using ELISA and western blotting. Lipid accumulation was determined with the use of immunohistochemistry and immunofluorescent staining.ResultsThe serum GAL-3BP level was found to be positively associated with MetS. The logistic regression analyses demonstrated that participants expressing the upper levels of GAL-3BP were more likely to develop MetS than those expressing less of the glycoprotein (OR = 2.39, 95%CI: 1.49, 3.83). The association between the serum GAL-3BP level and MetS was found preferentially in postmenopausal women (OR = 2.30, 95%CI: 1.31, 4.05). In addition, GAL-3BP was increased in the serum and visceral adipose tissue (VAT) of high fat diet (HFD) mice. Moreover, GAL-3BP was highly expressed in VAT macrophages.ConclusionsThis study confirmed serum GAL-3BP to be positively associated with MetS, highlighting it as a useful biological marker of MetS in Chinese participants.
format	article
author	Shihan Zhen Ruoxin Cai Xuelian Yang Yanan Ma Deliang Wen
author_facet	Shihan Zhen Ruoxin Cai Xuelian Yang Yanan Ma Deliang Wen
author_sort	Shihan Zhen
title	Association of Serum Galectin-3-Binding Protein and Metabolic Syndrome in a Chinese Adult Population
title_short	Association of Serum Galectin-3-Binding Protein and Metabolic Syndrome in a Chinese Adult Population
title_full	Association of Serum Galectin-3-Binding Protein and Metabolic Syndrome in a Chinese Adult Population
title_fullStr	Association of Serum Galectin-3-Binding Protein and Metabolic Syndrome in a Chinese Adult Population
title_full_unstemmed	Association of Serum Galectin-3-Binding Protein and Metabolic Syndrome in a Chinese Adult Population
title_sort	association of serum galectin-3-binding protein and metabolic syndrome in a chinese adult population
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/8efb7ff4a9c648fda1d2d2ed1202c885
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Association of Serum Galectin-3-Binding Protein and Metabolic Syndrome in a Chinese Adult Population

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