Mechanisms of Immunothrombosis by SARS-CoV-2

SARS-CoV-2 contains certain molecules that are related to the presence of immunothrombosis. Here, we review the pathogen and damage-associated molecular patterns. We also study the imbalance of different molecules participating in immunothrombosis, such as tissue factor, factors of the contact syste...

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Autores principales:	María Teresa Hernández-Huerta, Alma Dolores Pérez-Santiago, Laura Pérez-Campos Mayoral, Luis Manuel Sánchez Navarro, Francisco Javier Rodal Canales, Abraham Majluf-Cruz, Carlos Alberto Matias-Cervantes, Eduardo Pérez-Campos Mayoral, Carlos Romero Díaz, Gabriel Mayoral-Andrade, Margarito Martínez Cruz, Judith Luna Ángel, Eduardo Pérez-Campos
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	pathogen-associated molecular patterns damage-associated molecular patterns extracellular DNA extracellular RNA SARS-CoV-2 immunothrombosis Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/8f00532340884e39bc9f8d38a48c25c7
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spelling	oai:doaj.org-article:8f00532340884e39bc9f8d38a48c25c72021-11-25T16:51:42ZMechanisms of Immunothrombosis by SARS-CoV-210.3390/biom111115502218-273Xhttps://doaj.org/article/8f00532340884e39bc9f8d38a48c25c72021-10-01T00:00:00Zhttps://www.mdpi.com/2218-273X/11/11/1550https://doaj.org/toc/2218-273XSARS-CoV-2 contains certain molecules that are related to the presence of immunothrombosis. Here, we review the pathogen and damage-associated molecular patterns. We also study the imbalance of different molecules participating in immunothrombosis, such as tissue factor, factors of the contact system, histones, and the role of cells, such as endothelial cells, platelets, and neutrophil extracellular traps. Regarding the pathogenetic mechanism, we discuss clinical trials, case-control studies, comparative and translational studies, and observational studies of regulatory or inhibitory molecules, more specifically, extracellular DNA and RNA, histones, sensors for RNA and DNA, as well as heparin and heparinoids. Overall, it appears that a network of cells and molecules identified in this axis is simultaneously but differentially affecting patients at different stages of COVID-19, and this is characterized by endothelial damage, microthrombosis, and inflammation.María Teresa Hernández-HuertaAlma Dolores Pérez-SantiagoLaura Pérez-Campos MayoralLuis Manuel Sánchez NavarroFrancisco Javier Rodal CanalesAbraham Majluf-CruzCarlos Alberto Matias-CervantesEduardo Pérez-Campos MayoralCarlos Romero DíazGabriel Mayoral-AndradeMargarito Martínez CruzJudith Luna ÁngelEduardo Pérez-CamposMDPI AGarticlepathogen-associated molecular patternsdamage-associated molecular patternsextracellular DNAextracellular RNASARS-CoV-2immunothrombosisMicrobiologyQR1-502ENBiomolecules, Vol 11, Iss 1550, p 1550 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	pathogen-associated molecular patterns damage-associated molecular patterns extracellular DNA extracellular RNA SARS-CoV-2 immunothrombosis Microbiology QR1-502
spellingShingle	pathogen-associated molecular patterns damage-associated molecular patterns extracellular DNA extracellular RNA SARS-CoV-2 immunothrombosis Microbiology QR1-502 María Teresa Hernández-Huerta Alma Dolores Pérez-Santiago Laura Pérez-Campos Mayoral Luis Manuel Sánchez Navarro Francisco Javier Rodal Canales Abraham Majluf-Cruz Carlos Alberto Matias-Cervantes Eduardo Pérez-Campos Mayoral Carlos Romero Díaz Gabriel Mayoral-Andrade Margarito Martínez Cruz Judith Luna Ángel Eduardo Pérez-Campos Mechanisms of Immunothrombosis by SARS-CoV-2
description	SARS-CoV-2 contains certain molecules that are related to the presence of immunothrombosis. Here, we review the pathogen and damage-associated molecular patterns. We also study the imbalance of different molecules participating in immunothrombosis, such as tissue factor, factors of the contact system, histones, and the role of cells, such as endothelial cells, platelets, and neutrophil extracellular traps. Regarding the pathogenetic mechanism, we discuss clinical trials, case-control studies, comparative and translational studies, and observational studies of regulatory or inhibitory molecules, more specifically, extracellular DNA and RNA, histones, sensors for RNA and DNA, as well as heparin and heparinoids. Overall, it appears that a network of cells and molecules identified in this axis is simultaneously but differentially affecting patients at different stages of COVID-19, and this is characterized by endothelial damage, microthrombosis, and inflammation.
format	article
author	María Teresa Hernández-Huerta Alma Dolores Pérez-Santiago Laura Pérez-Campos Mayoral Luis Manuel Sánchez Navarro Francisco Javier Rodal Canales Abraham Majluf-Cruz Carlos Alberto Matias-Cervantes Eduardo Pérez-Campos Mayoral Carlos Romero Díaz Gabriel Mayoral-Andrade Margarito Martínez Cruz Judith Luna Ángel Eduardo Pérez-Campos
author_facet	María Teresa Hernández-Huerta Alma Dolores Pérez-Santiago Laura Pérez-Campos Mayoral Luis Manuel Sánchez Navarro Francisco Javier Rodal Canales Abraham Majluf-Cruz Carlos Alberto Matias-Cervantes Eduardo Pérez-Campos Mayoral Carlos Romero Díaz Gabriel Mayoral-Andrade Margarito Martínez Cruz Judith Luna Ángel Eduardo Pérez-Campos
author_sort	María Teresa Hernández-Huerta
title	Mechanisms of Immunothrombosis by SARS-CoV-2
title_short	Mechanisms of Immunothrombosis by SARS-CoV-2
title_full	Mechanisms of Immunothrombosis by SARS-CoV-2
title_fullStr	Mechanisms of Immunothrombosis by SARS-CoV-2
title_full_unstemmed	Mechanisms of Immunothrombosis by SARS-CoV-2
title_sort	mechanisms of immunothrombosis by sars-cov-2
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/8f00532340884e39bc9f8d38a48c25c7
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Mechanisms of Immunothrombosis by SARS-CoV-2

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