Comment on: use of blood biomarkers to screen for obstructive sleep apnea

Burton Abrams Zeger-Abrams Inc., Elkins Park, PA, USAThe recently published paper in Nature and Science of Sleep1 describes a combination of blood biomarkers for obstructive sleep apnea (OSA) screening which is shown to have better sensitivity and selectivity than any one individually. The combinati...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autor principal:	Abrams B
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	biomarker sleep apnea HbA1c urate Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495
Acceso en línea:	https://doaj.org/article/8f0125e3e8134f5b89fd4f30c32987f2
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:8f0125e3e8134f5b89fd4f30c32987f2
record_format	dspace
spelling	oai:doaj.org-article:8f0125e3e8134f5b89fd4f30c32987f22021-12-02T07:57:05ZComment on: use of blood biomarkers to screen for obstructive sleep apnea1179-1608https://doaj.org/article/8f0125e3e8134f5b89fd4f30c32987f22018-10-01T00:00:00Zhttps://www.dovepress.com/comment-on-use-of-blood-biomarkers-to-screen-for-obstructive-sleep-apn-peer-reviewed-article-NSShttps://doaj.org/toc/1179-1608Burton Abrams Zeger-Abrams Inc., Elkins Park, PA, USAThe recently published paper in Nature and Science of Sleep1 describes a combination of blood biomarkers for obstructive sleep apnea (OSA) screening which is shown to have better sensitivity and selectivity than any one individually. The combination comprises elevated levels of glycated hemoglobin (HbA1c), C-reactive protein, and erythropoeitin. The combination algorithm alluded to in the paper requires a sufficiently elevated level above a threshold of the combination of the three constituents for further diagnostic testing to be recommended. Of course, OSA would have to have been present long enough for the elevated levels to occur in order for the proposed biomarker to indicate its likely presence. My comment on this paper questions not whether this screening tool is valid, but whether it is valid early enough in the development of OSA to initiate diagnosis and treatment before some irreversible life-threatening consequence of OSA develops.View original paper by Fleming and colleagues.Abrams BDove Medical Pressarticlebiomarkersleep apneaHbA1curatePsychiatryRC435-571Neurophysiology and neuropsychologyQP351-495ENNature and Science of Sleep, Vol Volume 10, Pp 313-315 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	biomarker sleep apnea HbA1c urate Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495
spellingShingle	biomarker sleep apnea HbA1c urate Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495 Abrams B Comment on: use of blood biomarkers to screen for obstructive sleep apnea
description	Burton Abrams Zeger-Abrams Inc., Elkins Park, PA, USAThe recently published paper in Nature and Science of Sleep1 describes a combination of blood biomarkers for obstructive sleep apnea (OSA) screening which is shown to have better sensitivity and selectivity than any one individually. The combination comprises elevated levels of glycated hemoglobin (HbA1c), C-reactive protein, and erythropoeitin. The combination algorithm alluded to in the paper requires a sufficiently elevated level above a threshold of the combination of the three constituents for further diagnostic testing to be recommended. Of course, OSA would have to have been present long enough for the elevated levels to occur in order for the proposed biomarker to indicate its likely presence. My comment on this paper questions not whether this screening tool is valid, but whether it is valid early enough in the development of OSA to initiate diagnosis and treatment before some irreversible life-threatening consequence of OSA develops.View original paper by Fleming and colleagues.
format	article
author	Abrams B
author_facet	Abrams B
author_sort	Abrams B
title	Comment on: use of blood biomarkers to screen for obstructive sleep apnea
title_short	Comment on: use of blood biomarkers to screen for obstructive sleep apnea
title_full	Comment on: use of blood biomarkers to screen for obstructive sleep apnea
title_fullStr	Comment on: use of blood biomarkers to screen for obstructive sleep apnea
title_full_unstemmed	Comment on: use of blood biomarkers to screen for obstructive sleep apnea
title_sort	comment on: use of blood biomarkers to screen for obstructive sleep apnea
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/8f0125e3e8134f5b89fd4f30c32987f2
work_keys_str_mv	AT abramsb commentonuseofbloodbiomarkerstoscreenforobstructivesleepapnea
_version_	1718399055163293696

Comment on: use of blood biomarkers to screen for obstructive sleep apnea

Ejemplares similares