Late Effects After Haematopoietic Stem Cell Transplantation in ALL, Long-Term Follow-Up and Transition: A Step Into Adult Life

Haematopoietic stem cell transplant (HSCT) can be a curative treatment for children and adolescents with very-high-risk acute lymphoblastic leukaemia (ALL). Improvements in supportive care and transplant techniques have led to increasing numbers of long-term survivors worldwide. However, conditionin...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Tamara Diesch-Furlanetto, Melissa Gabriel, Olga Zajac-Spychala, Alessandro Cattoni, Bianca A. W. Hoeben, Adriana Balduzzi
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	haematopoietic stem cell transplantation long-term survivors quality of life paediatric adolescence late effects Pediatrics RJ1-570
Acceso en línea:	https://doaj.org/article/8f061980016d4f60aaf9b9cff0269caa
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:8f061980016d4f60aaf9b9cff0269caa
record_format	dspace
spelling	oai:doaj.org-article:8f061980016d4f60aaf9b9cff0269caa2021-11-30T18:33:22ZLate Effects After Haematopoietic Stem Cell Transplantation in ALL, Long-Term Follow-Up and Transition: A Step Into Adult Life2296-236010.3389/fped.2021.773895https://doaj.org/article/8f061980016d4f60aaf9b9cff0269caa2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fped.2021.773895/fullhttps://doaj.org/toc/2296-2360Haematopoietic stem cell transplant (HSCT) can be a curative treatment for children and adolescents with very-high-risk acute lymphoblastic leukaemia (ALL). Improvements in supportive care and transplant techniques have led to increasing numbers of long-term survivors worldwide. However, conditioning regimens as well as transplant-related complications are associated with severe sequelae, impacting patients' quality of life. It is widely recognised that paediatric HSCT survivors must have timely access to life-long care and surveillance in order to prevent, ameliorate and manage all possible adverse late effects of HSCT. This is fundamentally important because it can both prevent ill health and optimise the quality and experience of survival following HSCT. Furthermore, it reduces the impact of preventable chronic illness on already under-resourced health services. In addition to late effects, survivors of paediatric ALL also have to deal with unique challenges associated with transition to adult services. In this review, we: (1) provide an overview of the potential late effects following HSCT for ALL in childhood and adolescence; (2) focus on the unique challenges of transition from paediatric care to adult services; and (3) provide a framework for long-term surveillance and medical care for survivors of paediatric ALL who have undergone HSCT.Tamara Diesch-FurlanettoMelissa GabrielOlga Zajac-SpychalaAlessandro CattoniBianca A. W. HoebenBianca A. W. HoebenAdriana BalduzziFrontiers Media S.A.articlehaematopoietic stem cell transplantationlong-term survivorsquality of lifepaediatricadolescencelate effectsPediatricsRJ1-570ENFrontiers in Pediatrics, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	haematopoietic stem cell transplantation long-term survivors quality of life paediatric adolescence late effects Pediatrics RJ1-570
spellingShingle	haematopoietic stem cell transplantation long-term survivors quality of life paediatric adolescence late effects Pediatrics RJ1-570 Tamara Diesch-Furlanetto Melissa Gabriel Olga Zajac-Spychala Alessandro Cattoni Bianca A. W. Hoeben Bianca A. W. Hoeben Adriana Balduzzi Late Effects After Haematopoietic Stem Cell Transplantation in ALL, Long-Term Follow-Up and Transition: A Step Into Adult Life
description	Haematopoietic stem cell transplant (HSCT) can be a curative treatment for children and adolescents with very-high-risk acute lymphoblastic leukaemia (ALL). Improvements in supportive care and transplant techniques have led to increasing numbers of long-term survivors worldwide. However, conditioning regimens as well as transplant-related complications are associated with severe sequelae, impacting patients' quality of life. It is widely recognised that paediatric HSCT survivors must have timely access to life-long care and surveillance in order to prevent, ameliorate and manage all possible adverse late effects of HSCT. This is fundamentally important because it can both prevent ill health and optimise the quality and experience of survival following HSCT. Furthermore, it reduces the impact of preventable chronic illness on already under-resourced health services. In addition to late effects, survivors of paediatric ALL also have to deal with unique challenges associated with transition to adult services. In this review, we: (1) provide an overview of the potential late effects following HSCT for ALL in childhood and adolescence; (2) focus on the unique challenges of transition from paediatric care to adult services; and (3) provide a framework for long-term surveillance and medical care for survivors of paediatric ALL who have undergone HSCT.
format	article
author	Tamara Diesch-Furlanetto Melissa Gabriel Olga Zajac-Spychala Alessandro Cattoni Bianca A. W. Hoeben Bianca A. W. Hoeben Adriana Balduzzi
author_facet	Tamara Diesch-Furlanetto Melissa Gabriel Olga Zajac-Spychala Alessandro Cattoni Bianca A. W. Hoeben Bianca A. W. Hoeben Adriana Balduzzi
author_sort	Tamara Diesch-Furlanetto
title	Late Effects After Haematopoietic Stem Cell Transplantation in ALL, Long-Term Follow-Up and Transition: A Step Into Adult Life
title_short	Late Effects After Haematopoietic Stem Cell Transplantation in ALL, Long-Term Follow-Up and Transition: A Step Into Adult Life
title_full	Late Effects After Haematopoietic Stem Cell Transplantation in ALL, Long-Term Follow-Up and Transition: A Step Into Adult Life
title_fullStr	Late Effects After Haematopoietic Stem Cell Transplantation in ALL, Long-Term Follow-Up and Transition: A Step Into Adult Life
title_full_unstemmed	Late Effects After Haematopoietic Stem Cell Transplantation in ALL, Long-Term Follow-Up and Transition: A Step Into Adult Life
title_sort	late effects after haematopoietic stem cell transplantation in all, long-term follow-up and transition: a step into adult life
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/8f061980016d4f60aaf9b9cff0269caa
work_keys_str_mv	AT tamaradieschfurlanetto lateeffectsafterhaematopoieticstemcelltransplantationinalllongtermfollowupandtransitionastepintoadultlife AT melissagabriel lateeffectsafterhaematopoieticstemcelltransplantationinalllongtermfollowupandtransitionastepintoadultlife AT olgazajacspychala lateeffectsafterhaematopoieticstemcelltransplantationinalllongtermfollowupandtransitionastepintoadultlife AT alessandrocattoni lateeffectsafterhaematopoieticstemcelltransplantationinalllongtermfollowupandtransitionastepintoadultlife AT biancaawhoeben lateeffectsafterhaematopoieticstemcelltransplantationinalllongtermfollowupandtransitionastepintoadultlife AT biancaawhoeben lateeffectsafterhaematopoieticstemcelltransplantationinalllongtermfollowupandtransitionastepintoadultlife AT adrianabalduzzi lateeffectsafterhaematopoieticstemcelltransplantationinalllongtermfollowupandtransitionastepintoadultlife
_version_	1718406339636494336

Late Effects After Haematopoietic Stem Cell Transplantation in ALL, Long-Term Follow-Up and Transition: A Step Into Adult Life

Ejemplares similares