Identified micro-organisms in hospitalized community-acquired pneumonia patients living near goat and poultry farms

Abstract Background In the Netherlands, an increased risk of community-acquired pneumonia (CAP) has been reported for adults living near goat and poultry farms. Previous results of respiratory microbiome studies in hospitalized CAP patients near poultry farms suggested a higher relative abundance of...

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Autores principales:	Inge Roof, Arianne B. van Gageldonk-Lafeber, Tizza P. Zomer, Yolande M. Vermeeren, Peter C. Wever, Wim van der Hoek
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Community-acquired pneumonia Etiology Goat farms Poultry farms Livestock Diseases of the respiratory system RC705-779
Acceso en línea:	https://doaj.org/article/8f088b535dea49c583f6461df387fe64
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spelling	oai:doaj.org-article:8f088b535dea49c583f6461df387fe642021-12-05T12:03:53ZIdentified micro-organisms in hospitalized community-acquired pneumonia patients living near goat and poultry farms10.1186/s41479-021-00091-w2200-6133https://doaj.org/article/8f088b535dea49c583f6461df387fe642021-11-01T00:00:00Zhttps://doi.org/10.1186/s41479-021-00091-whttps://doaj.org/toc/2200-6133Abstract Background In the Netherlands, an increased risk of community-acquired pneumonia (CAP) has been reported for adults living near goat and poultry farms. Previous results of respiratory microbiome studies in hospitalized CAP patients near poultry farms suggested a higher relative abundance of Streptococcus pneumoniae. This retrospective study, using routine laboratory data from hospitalized CAP patients, aims to explore possible aetiologic micro-organisms of CAP in relation to livestock exposure. Methods Patient characteristics and PCR and urinary antigen test results were retrieved retrospectively from electronic medical records of CAP patients admitted to the Jeroen Bosch Hospital or Gelre Hospital in the Netherlands during 2016–2017. Distances between the patients’ home address and the nearest poultry and goat farm were calculated. Differences in laboratory test results between CAP patients with and without goat or poultry farms within 2 km of their home address were analyzed using Fisher’s exact test. Results In total, 2230 CAP episodes with diagnostic results were included. In only 25% of the CAP episodes, a micro-organism was detected. A positive urinary antigen test for S. pneumoniae was found more often in patients living within two kilometers of goat (15.2% vs. 11.3%) and poultry farms (14.4% vs. 11.3%), however these differences were not statistically significant (p = 0.1047 and p = 0.1376). Conclusion Our retrospective analysis did not show statistically significant differences in the identified micro-organisms in hospitalized CAP patients related to livestock farming. The study was hampered by limited statistical power and limited laboratory results. Therefore, the potential increased CAP risk around goat and poultry farms will be further explored in a prospective study among CAP patients in primary care.Inge RoofArianne B. van Gageldonk-LafeberTizza P. ZomerYolande M. VermeerenPeter C. WeverWim van der HoekBMCarticleCommunity-acquired pneumoniaEtiologyGoat farmsPoultry farmsLivestockDiseases of the respiratory systemRC705-779ENPneumonia, Vol 13, Iss 1, Pp 1-5 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Community-acquired pneumonia Etiology Goat farms Poultry farms Livestock Diseases of the respiratory system RC705-779
spellingShingle	Community-acquired pneumonia Etiology Goat farms Poultry farms Livestock Diseases of the respiratory system RC705-779 Inge Roof Arianne B. van Gageldonk-Lafeber Tizza P. Zomer Yolande M. Vermeeren Peter C. Wever Wim van der Hoek Identified micro-organisms in hospitalized community-acquired pneumonia patients living near goat and poultry farms
description	Abstract Background In the Netherlands, an increased risk of community-acquired pneumonia (CAP) has been reported for adults living near goat and poultry farms. Previous results of respiratory microbiome studies in hospitalized CAP patients near poultry farms suggested a higher relative abundance of Streptococcus pneumoniae. This retrospective study, using routine laboratory data from hospitalized CAP patients, aims to explore possible aetiologic micro-organisms of CAP in relation to livestock exposure. Methods Patient characteristics and PCR and urinary antigen test results were retrieved retrospectively from electronic medical records of CAP patients admitted to the Jeroen Bosch Hospital or Gelre Hospital in the Netherlands during 2016–2017. Distances between the patients’ home address and the nearest poultry and goat farm were calculated. Differences in laboratory test results between CAP patients with and without goat or poultry farms within 2 km of their home address were analyzed using Fisher’s exact test. Results In total, 2230 CAP episodes with diagnostic results were included. In only 25% of the CAP episodes, a micro-organism was detected. A positive urinary antigen test for S. pneumoniae was found more often in patients living within two kilometers of goat (15.2% vs. 11.3%) and poultry farms (14.4% vs. 11.3%), however these differences were not statistically significant (p = 0.1047 and p = 0.1376). Conclusion Our retrospective analysis did not show statistically significant differences in the identified micro-organisms in hospitalized CAP patients related to livestock farming. The study was hampered by limited statistical power and limited laboratory results. Therefore, the potential increased CAP risk around goat and poultry farms will be further explored in a prospective study among CAP patients in primary care.
format	article
author	Inge Roof Arianne B. van Gageldonk-Lafeber Tizza P. Zomer Yolande M. Vermeeren Peter C. Wever Wim van der Hoek
author_facet	Inge Roof Arianne B. van Gageldonk-Lafeber Tizza P. Zomer Yolande M. Vermeeren Peter C. Wever Wim van der Hoek
author_sort	Inge Roof
title	Identified micro-organisms in hospitalized community-acquired pneumonia patients living near goat and poultry farms
title_short	Identified micro-organisms in hospitalized community-acquired pneumonia patients living near goat and poultry farms
title_full	Identified micro-organisms in hospitalized community-acquired pneumonia patients living near goat and poultry farms
title_fullStr	Identified micro-organisms in hospitalized community-acquired pneumonia patients living near goat and poultry farms
title_full_unstemmed	Identified micro-organisms in hospitalized community-acquired pneumonia patients living near goat and poultry farms
title_sort	identified micro-organisms in hospitalized community-acquired pneumonia patients living near goat and poultry farms
publisher	BMC
publishDate	2021
url	https://doaj.org/article/8f088b535dea49c583f6461df387fe64
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Identified micro-organisms in hospitalized community-acquired pneumonia patients living near goat and poultry farms

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