Circular RNA circRAB31 acts as a miR-885-5psponge to suppress gastric cancer progressionvia the PTEN/PI3K/AKT pathway

Emerging evidence indicated that circular RNAs (circRNAs) play essential roles in cancer progression. A large number of circRNAs have been reported to modulate cancer carcinogenesis. However, the underlying mechanisms by which circRNAs regulate gastric cancer remain largely unclear. By using circRNA...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Xianlong Liang, Chuan Qin, Gangfeng Yu, Xiong Guo, Anqi Cheng, Han Zhang, Ziwei Wang
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	circRNA miRNA gastric cancer ceRNA PTEN Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/8f0b958d0fad4cba94c5300184756fed
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:8f0b958d0fad4cba94c5300184756fed
record_format	dspace
spelling	oai:doaj.org-article:8f0b958d0fad4cba94c5300184756fed2021-11-28T04:34:40ZCircular RNA circRAB31 acts as a miR-885-5psponge to suppress gastric cancer progressionvia the PTEN/PI3K/AKT pathway2372-770510.1016/j.omto.2021.11.002https://doaj.org/article/8f0b958d0fad4cba94c5300184756fed2021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2372770521001510https://doaj.org/toc/2372-7705Emerging evidence indicated that circular RNAs (circRNAs) play essential roles in cancer progression. A large number of circRNAs have been reported to modulate cancer carcinogenesis. However, the underlying mechanisms by which circRNAs regulate gastric cancer remain largely unclear. By using circRNA microarray, we identified that circRAB31 may serve as a tumor suppressor. circRAB31 was downregulated in gastric cancer tissues and gastric cancer cell lines compared with normal tissues and a human gastric epithelial cell line (GES-1). Overexpression of circRAB31 suppressed gastric cancer proliferation and metastasis in vitro and in vivo, whereas silencing of circRAB31 had the opposite effects. Bioinformatic analysis as well as pull-down and luciferase assays revealed that circRAB31 exerted tumor-suppressive functions by binding directly to miR-885-5p. In addition, we demonstrated that circRAB31 could suppress PI3K/AKT signaling via the phosphatase and tensin homologue (PTEN)—a downstream target gene of miR-885-5p. In summary, our results demonstrated that circRAB31 could serve as a sponge of miR-885-5p to regulate gastric cancer cell proliferation, migration, and invasion by affecting the PTEN/PI3K/AKT signaling.Xianlong LiangChuan QinGangfeng YuXiong GuoAnqi ChengHan ZhangZiwei WangElsevierarticlecircRNAmiRNAgastric cancerceRNAPTENNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENMolecular Therapy: Oncolytics, Vol 23, Iss , Pp 501-514 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	circRNA miRNA gastric cancer ceRNA PTEN Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	circRNA miRNA gastric cancer ceRNA PTEN Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Xianlong Liang Chuan Qin Gangfeng Yu Xiong Guo Anqi Cheng Han Zhang Ziwei Wang Circular RNA circRAB31 acts as a miR-885-5psponge to suppress gastric cancer progressionvia the PTEN/PI3K/AKT pathway
description	Emerging evidence indicated that circular RNAs (circRNAs) play essential roles in cancer progression. A large number of circRNAs have been reported to modulate cancer carcinogenesis. However, the underlying mechanisms by which circRNAs regulate gastric cancer remain largely unclear. By using circRNA microarray, we identified that circRAB31 may serve as a tumor suppressor. circRAB31 was downregulated in gastric cancer tissues and gastric cancer cell lines compared with normal tissues and a human gastric epithelial cell line (GES-1). Overexpression of circRAB31 suppressed gastric cancer proliferation and metastasis in vitro and in vivo, whereas silencing of circRAB31 had the opposite effects. Bioinformatic analysis as well as pull-down and luciferase assays revealed that circRAB31 exerted tumor-suppressive functions by binding directly to miR-885-5p. In addition, we demonstrated that circRAB31 could suppress PI3K/AKT signaling via the phosphatase and tensin homologue (PTEN)—a downstream target gene of miR-885-5p. In summary, our results demonstrated that circRAB31 could serve as a sponge of miR-885-5p to regulate gastric cancer cell proliferation, migration, and invasion by affecting the PTEN/PI3K/AKT signaling.
format	article
author	Xianlong Liang Chuan Qin Gangfeng Yu Xiong Guo Anqi Cheng Han Zhang Ziwei Wang
author_facet	Xianlong Liang Chuan Qin Gangfeng Yu Xiong Guo Anqi Cheng Han Zhang Ziwei Wang
author_sort	Xianlong Liang
title	Circular RNA circRAB31 acts as a miR-885-5psponge to suppress gastric cancer progressionvia the PTEN/PI3K/AKT pathway
title_short	Circular RNA circRAB31 acts as a miR-885-5psponge to suppress gastric cancer progressionvia the PTEN/PI3K/AKT pathway
title_full	Circular RNA circRAB31 acts as a miR-885-5psponge to suppress gastric cancer progressionvia the PTEN/PI3K/AKT pathway
title_fullStr	Circular RNA circRAB31 acts as a miR-885-5psponge to suppress gastric cancer progressionvia the PTEN/PI3K/AKT pathway
title_full_unstemmed	Circular RNA circRAB31 acts as a miR-885-5psponge to suppress gastric cancer progressionvia the PTEN/PI3K/AKT pathway
title_sort	circular rna circrab31 acts as a mir-885-5psponge to suppress gastric cancer progressionvia the pten/pi3k/akt pathway
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/8f0b958d0fad4cba94c5300184756fed
work_keys_str_mv	AT xianlongliang circularrnacircrab31actsasamir8855pspongetosuppressgastriccancerprogressionviatheptenpi3kaktpathway AT chuanqin circularrnacircrab31actsasamir8855pspongetosuppressgastriccancerprogressionviatheptenpi3kaktpathway AT gangfengyu circularrnacircrab31actsasamir8855pspongetosuppressgastriccancerprogressionviatheptenpi3kaktpathway AT xiongguo circularrnacircrab31actsasamir8855pspongetosuppressgastriccancerprogressionviatheptenpi3kaktpathway AT anqicheng circularrnacircrab31actsasamir8855pspongetosuppressgastriccancerprogressionviatheptenpi3kaktpathway AT hanzhang circularrnacircrab31actsasamir8855pspongetosuppressgastriccancerprogressionviatheptenpi3kaktpathway AT ziweiwang circularrnacircrab31actsasamir8855pspongetosuppressgastriccancerprogressionviatheptenpi3kaktpathway
_version_	1718408330091692032

Circular RNA circRAB31 acts as a miR-885-5psponge to suppress gastric cancer progressionvia the PTEN/PI3K/AKT pathway

Ejemplares similares