The recurrence rate of ovarian endometrioma in women aged 40–49 years and impact of hormonal treatment after conservative surgery

Abstract The aim of this study was to evaluate the rate of and risk factors for recurrence ovarian endometrioma after conservative surgery in patients aged 40–49 years. This retrospective, single-center study included 408 women between January 2008 and November 2018. All patients underwent ovarian c...

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Autores principales:	Nara Lee, Seunggi Min, Seyeon Won, Yeon Jean Cho, Miseon Kim, Mi Kyoung Kim, Yong Wook Jung, Bo Seong Yun, Seok Ju Seong, Mi-La Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8f0be233e08d44659b5b03e7adb61f94
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spelling	oai:doaj.org-article:8f0be233e08d44659b5b03e7adb61f942021-12-02T18:37:07ZThe recurrence rate of ovarian endometrioma in women aged 40–49 years and impact of hormonal treatment after conservative surgery10.1038/s41598-020-73434-02045-2322https://doaj.org/article/8f0be233e08d44659b5b03e7adb61f942020-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-73434-0https://doaj.org/toc/2045-2322Abstract The aim of this study was to evaluate the rate of and risk factors for recurrence ovarian endometrioma after conservative surgery in patients aged 40–49 years. This retrospective, single-center study included 408 women between January 2008 and November 2018. All patients underwent ovarian cyst enucleation, were pathologically diagnosed with ovarian endometrioma and were followed up for ≥ 6 months. Recurrence was defined as a cystic mass with diameter ≥ 2 cm detected by sonography. Recurrence rate after conservative surgery and risk factor of recurrence were analyzed. The median follow-up duration after surgery was 32.0 ± 25.9 months (range 6–125 months). Ovarian endometrioma recurred in 34 (8.3%) of included women and median time to recurrence was 22.4 ± 18.2 months. The cumulative recurrences rate at 12, 24, 36, and 60 months were 3.7%, 6.7%, 11.1%, and 16.7%, respectively. Recurrence was correlated with multilocular cysts (p = 0.038), previous surgical history of ovarian endometrioma (p = 0.006) and salpingectomy (p = 0.043), but not use or duration of post-operative medication. In multivariate analysis, large cyst size (> 5.5 cm) was only risk factor for recurrence in this age group. Post-operative medication did not reduce disease recurrence rate, and thus may be administered for endometriosis-associated pain rather than to prevent recurrence in patients aged 40–49 years.Nara LeeSeunggi MinSeyeon WonYeon Jean ChoMiseon KimMi Kyoung KimYong Wook JungBo Seong YunSeok Ju SeongMi-La KimNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nara Lee Seunggi Min Seyeon Won Yeon Jean Cho Miseon Kim Mi Kyoung Kim Yong Wook Jung Bo Seong Yun Seok Ju Seong Mi-La Kim The recurrence rate of ovarian endometrioma in women aged 40–49 years and impact of hormonal treatment after conservative surgery
description	Abstract The aim of this study was to evaluate the rate of and risk factors for recurrence ovarian endometrioma after conservative surgery in patients aged 40–49 years. This retrospective, single-center study included 408 women between January 2008 and November 2018. All patients underwent ovarian cyst enucleation, were pathologically diagnosed with ovarian endometrioma and were followed up for ≥ 6 months. Recurrence was defined as a cystic mass with diameter ≥ 2 cm detected by sonography. Recurrence rate after conservative surgery and risk factor of recurrence were analyzed. The median follow-up duration after surgery was 32.0 ± 25.9 months (range 6–125 months). Ovarian endometrioma recurred in 34 (8.3%) of included women and median time to recurrence was 22.4 ± 18.2 months. The cumulative recurrences rate at 12, 24, 36, and 60 months were 3.7%, 6.7%, 11.1%, and 16.7%, respectively. Recurrence was correlated with multilocular cysts (p = 0.038), previous surgical history of ovarian endometrioma (p = 0.006) and salpingectomy (p = 0.043), but not use or duration of post-operative medication. In multivariate analysis, large cyst size (> 5.5 cm) was only risk factor for recurrence in this age group. Post-operative medication did not reduce disease recurrence rate, and thus may be administered for endometriosis-associated pain rather than to prevent recurrence in patients aged 40–49 years.
format	article
author	Nara Lee Seunggi Min Seyeon Won Yeon Jean Cho Miseon Kim Mi Kyoung Kim Yong Wook Jung Bo Seong Yun Seok Ju Seong Mi-La Kim
author_facet	Nara Lee Seunggi Min Seyeon Won Yeon Jean Cho Miseon Kim Mi Kyoung Kim Yong Wook Jung Bo Seong Yun Seok Ju Seong Mi-La Kim
author_sort	Nara Lee
title	The recurrence rate of ovarian endometrioma in women aged 40–49 years and impact of hormonal treatment after conservative surgery
title_short	The recurrence rate of ovarian endometrioma in women aged 40–49 years and impact of hormonal treatment after conservative surgery
title_full	The recurrence rate of ovarian endometrioma in women aged 40–49 years and impact of hormonal treatment after conservative surgery
title_fullStr	The recurrence rate of ovarian endometrioma in women aged 40–49 years and impact of hormonal treatment after conservative surgery
title_full_unstemmed	The recurrence rate of ovarian endometrioma in women aged 40–49 years and impact of hormonal treatment after conservative surgery
title_sort	recurrence rate of ovarian endometrioma in women aged 40–49 years and impact of hormonal treatment after conservative surgery
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/8f0be233e08d44659b5b03e7adb61f94
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The recurrence rate of ovarian endometrioma in women aged 40–49 years and impact of hormonal treatment after conservative surgery

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