ROS Pleiotropy in Melanoma and Local Therapy with Physical Modalities

Metabolic energy production naturally generates unwanted products such as reactive oxygen species (ROS), causing oxidative damage. Oxidative damage has been linked to several pathologies, including diabetes, premature aging, neurodegenerative diseases, and cancer. ROS were therefore originally antic...

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Autores principales:	Sanjeev Kumar Sagwal, Sander Bekeschus
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Cytology QH573-671
Acceso en línea:	https://doaj.org/article/8f0dbabf74844739830a47d32a9bd82b
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spelling	oai:doaj.org-article:8f0dbabf74844739830a47d32a9bd82b2021-11-15T01:20:08ZROS Pleiotropy in Melanoma and Local Therapy with Physical Modalities1942-099410.1155/2021/6816214https://doaj.org/article/8f0dbabf74844739830a47d32a9bd82b2021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/6816214https://doaj.org/toc/1942-0994Metabolic energy production naturally generates unwanted products such as reactive oxygen species (ROS), causing oxidative damage. Oxidative damage has been linked to several pathologies, including diabetes, premature aging, neurodegenerative diseases, and cancer. ROS were therefore originally anticipated as an imperative evil, a product of an imperfect system. More recently, however, the role of ROS in signaling and tumor treatment is increasingly acknowledged. This review addresses the main types, sources, and pathways of ROS in melanoma by linking their pleiotropic roles in antioxidant and oxidant regulation, hypoxia, metabolism, and cell death. In addition, the implications of ROS in various physical therapy modalities targeting melanoma, such as radiotherapy, electrochemotherapy, hyperthermia, photodynamic therapy, and medical gas plasma, are also discussed. By including ROS in the main picture of melanoma skin cancer and as an integral part of cancer therapies, a greater understanding of melanoma cell biology is presented, which ultimately may elucidate additional clues on targeting therapy resistance of this most deadly form of skin cancer.Sanjeev Kumar SagwalSander BekeschusHindawi LimitedarticleCytologyQH573-671ENOxidative Medicine and Cellular Longevity, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cytology QH573-671
spellingShingle	Cytology QH573-671 Sanjeev Kumar Sagwal Sander Bekeschus ROS Pleiotropy in Melanoma and Local Therapy with Physical Modalities
description	Metabolic energy production naturally generates unwanted products such as reactive oxygen species (ROS), causing oxidative damage. Oxidative damage has been linked to several pathologies, including diabetes, premature aging, neurodegenerative diseases, and cancer. ROS were therefore originally anticipated as an imperative evil, a product of an imperfect system. More recently, however, the role of ROS in signaling and tumor treatment is increasingly acknowledged. This review addresses the main types, sources, and pathways of ROS in melanoma by linking their pleiotropic roles in antioxidant and oxidant regulation, hypoxia, metabolism, and cell death. In addition, the implications of ROS in various physical therapy modalities targeting melanoma, such as radiotherapy, electrochemotherapy, hyperthermia, photodynamic therapy, and medical gas plasma, are also discussed. By including ROS in the main picture of melanoma skin cancer and as an integral part of cancer therapies, a greater understanding of melanoma cell biology is presented, which ultimately may elucidate additional clues on targeting therapy resistance of this most deadly form of skin cancer.
format	article
author	Sanjeev Kumar Sagwal Sander Bekeschus
author_facet	Sanjeev Kumar Sagwal Sander Bekeschus
author_sort	Sanjeev Kumar Sagwal
title	ROS Pleiotropy in Melanoma and Local Therapy with Physical Modalities
title_short	ROS Pleiotropy in Melanoma and Local Therapy with Physical Modalities
title_full	ROS Pleiotropy in Melanoma and Local Therapy with Physical Modalities
title_fullStr	ROS Pleiotropy in Melanoma and Local Therapy with Physical Modalities
title_full_unstemmed	ROS Pleiotropy in Melanoma and Local Therapy with Physical Modalities
title_sort	ros pleiotropy in melanoma and local therapy with physical modalities
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/8f0dbabf74844739830a47d32a9bd82b
work_keys_str_mv	AT sanjeevkumarsagwal rospleiotropyinmelanomaandlocaltherapywithphysicalmodalities AT sanderbekeschus rospleiotropyinmelanomaandlocaltherapywithphysicalmodalities
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ROS Pleiotropy in Melanoma and Local Therapy with Physical Modalities

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