The Perspectives of Early Diagnosis of Schizophrenia Through the Detection of Epigenomics-Based Biomarkers in iPSC-Derived Neurons

The lack of early diagnostic biomarkers for schizophrenia greatly limits treatment options that deliver therapeutic agents to affected cells at a timely manner. While previous schizophrenia biomarker research has identified various biological signals that are correlated with certain diseases, their...

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Autores principales:	Davin Lee, Jinsoo Seo, Hae chan Jeong, Hyosang Lee, Sung Bae Lee
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	schizophrenia iPSC organoid epigenetic alteration transcriptional alteration Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/8f0e77b326464418bbc9c9772a40590e
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spelling	oai:doaj.org-article:8f0e77b326464418bbc9c9772a40590e2021-11-12T13:17:42ZThe Perspectives of Early Diagnosis of Schizophrenia Through the Detection of Epigenomics-Based Biomarkers in iPSC-Derived Neurons1662-509910.3389/fnmol.2021.756613https://doaj.org/article/8f0e77b326464418bbc9c9772a40590e2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnmol.2021.756613/fullhttps://doaj.org/toc/1662-5099The lack of early diagnostic biomarkers for schizophrenia greatly limits treatment options that deliver therapeutic agents to affected cells at a timely manner. While previous schizophrenia biomarker research has identified various biological signals that are correlated with certain diseases, their reliability and practicality as an early diagnostic tool remains unclear. In this article, we discuss the use of atypical epigenetic and/or consequent transcriptional alterations (ETAs) as biomarkers of early-stage schizophrenia. Furthermore, we review the viability of discovering and applying these biomarkers through the use of cutting-edge technologies such as human induced pluripotent stem cell (iPSC)-derived neurons, brain models, and single-cell level analyses.Davin LeeJinsoo SeoHae chan JeongHyosang LeeSung Bae LeeFrontiers Media S.A.articleschizophreniaiPSCorganoidepigenetic alterationtranscriptional alterationNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Molecular Neuroscience, Vol 14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	schizophrenia iPSC organoid epigenetic alteration transcriptional alteration Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	schizophrenia iPSC organoid epigenetic alteration transcriptional alteration Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Davin Lee Jinsoo Seo Hae chan Jeong Hyosang Lee Sung Bae Lee The Perspectives of Early Diagnosis of Schizophrenia Through the Detection of Epigenomics-Based Biomarkers in iPSC-Derived Neurons
description	The lack of early diagnostic biomarkers for schizophrenia greatly limits treatment options that deliver therapeutic agents to affected cells at a timely manner. While previous schizophrenia biomarker research has identified various biological signals that are correlated with certain diseases, their reliability and practicality as an early diagnostic tool remains unclear. In this article, we discuss the use of atypical epigenetic and/or consequent transcriptional alterations (ETAs) as biomarkers of early-stage schizophrenia. Furthermore, we review the viability of discovering and applying these biomarkers through the use of cutting-edge technologies such as human induced pluripotent stem cell (iPSC)-derived neurons, brain models, and single-cell level analyses.
format	article
author	Davin Lee Jinsoo Seo Hae chan Jeong Hyosang Lee Sung Bae Lee
author_facet	Davin Lee Jinsoo Seo Hae chan Jeong Hyosang Lee Sung Bae Lee
author_sort	Davin Lee
title	The Perspectives of Early Diagnosis of Schizophrenia Through the Detection of Epigenomics-Based Biomarkers in iPSC-Derived Neurons
title_short	The Perspectives of Early Diagnosis of Schizophrenia Through the Detection of Epigenomics-Based Biomarkers in iPSC-Derived Neurons
title_full	The Perspectives of Early Diagnosis of Schizophrenia Through the Detection of Epigenomics-Based Biomarkers in iPSC-Derived Neurons
title_fullStr	The Perspectives of Early Diagnosis of Schizophrenia Through the Detection of Epigenomics-Based Biomarkers in iPSC-Derived Neurons
title_full_unstemmed	The Perspectives of Early Diagnosis of Schizophrenia Through the Detection of Epigenomics-Based Biomarkers in iPSC-Derived Neurons
title_sort	perspectives of early diagnosis of schizophrenia through the detection of epigenomics-based biomarkers in ipsc-derived neurons
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/8f0e77b326464418bbc9c9772a40590e
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The Perspectives of Early Diagnosis of Schizophrenia Through the Detection of Epigenomics-Based Biomarkers in iPSC-Derived Neurons

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