Genetic background influences the effect of thirdhand smoke exposure on anxiety and memory in Collaborative Cross mice

Abstract Growing evidence indicates that thirdhand smoke (THS) exposure induces many adverse health effects. However, it is unclear how THS exposure affects behavior and how host genetic background modulates phenotypic changes. Here we used the Collaborative Cross (CC) mouse population-based model t...

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Autores principales:	Li He, Pin Wang, Suzyann F. Schick, Abel Huang, Peyton Jacob, Xu Yang, Yankai Xia, Antoine M. Snijders, Jian-Hua Mao, Hang Chang, Bo Hang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8f0ef1011a3745c9a7612040e1d18c2c
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spelling	oai:doaj.org-article:8f0ef1011a3745c9a7612040e1d18c2c2021-12-02T17:12:17ZGenetic background influences the effect of thirdhand smoke exposure on anxiety and memory in Collaborative Cross mice10.1038/s41598-021-92702-12045-2322https://doaj.org/article/8f0ef1011a3745c9a7612040e1d18c2c2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92702-1https://doaj.org/toc/2045-2322Abstract Growing evidence indicates that thirdhand smoke (THS) exposure induces many adverse health effects. However, it is unclear how THS exposure affects behavior and how host genetic background modulates phenotypic changes. Here we used the Collaborative Cross (CC) mouse population-based model to assess behavioral alterations immediately after THS exposure from 4 to 9 weeks of age. We first measured anxiety-like behavior in six strains using light/dark box combined with a custom multivariate mouse tracking system. We developed an anxiety risk scoring system based on anxiety-related traits and then evaluated the THS impact on them. THS exposure significantly decreased anxiety risk in CC019 (P = 0.002) and CC051 (P = 0.009), but increased anxiety risk in CC036 (P < 0.001), while the other three strains did not show significant changes in anxiety-related traits. Such differences were driven by female mice for the six measures of anxiety-like behavior. Memory potential was measured in the same cohort of mice using the passive avoidance assay. Both THS-exposed male and female CC019 mice displayed significant memory loss compared to controls while no significant changes were found in the other five strains. This study provides strong evidence that THS exposure leads to strain-dependent changes in anxiety-like behavior and memory, suggesting that host genetic variations play a critical role in individual susceptibility to THS-induced effects.Li HePin WangSuzyann F. SchickAbel HuangPeyton JacobXu YangYankai XiaAntoine M. SnijdersJian-Hua MaoHang ChangBo HangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Li He Pin Wang Suzyann F. Schick Abel Huang Peyton Jacob Xu Yang Yankai Xia Antoine M. Snijders Jian-Hua Mao Hang Chang Bo Hang Genetic background influences the effect of thirdhand smoke exposure on anxiety and memory in Collaborative Cross mice
description	Abstract Growing evidence indicates that thirdhand smoke (THS) exposure induces many adverse health effects. However, it is unclear how THS exposure affects behavior and how host genetic background modulates phenotypic changes. Here we used the Collaborative Cross (CC) mouse population-based model to assess behavioral alterations immediately after THS exposure from 4 to 9 weeks of age. We first measured anxiety-like behavior in six strains using light/dark box combined with a custom multivariate mouse tracking system. We developed an anxiety risk scoring system based on anxiety-related traits and then evaluated the THS impact on them. THS exposure significantly decreased anxiety risk in CC019 (P = 0.002) and CC051 (P = 0.009), but increased anxiety risk in CC036 (P < 0.001), while the other three strains did not show significant changes in anxiety-related traits. Such differences were driven by female mice for the six measures of anxiety-like behavior. Memory potential was measured in the same cohort of mice using the passive avoidance assay. Both THS-exposed male and female CC019 mice displayed significant memory loss compared to controls while no significant changes were found in the other five strains. This study provides strong evidence that THS exposure leads to strain-dependent changes in anxiety-like behavior and memory, suggesting that host genetic variations play a critical role in individual susceptibility to THS-induced effects.
format	article
author	Li He Pin Wang Suzyann F. Schick Abel Huang Peyton Jacob Xu Yang Yankai Xia Antoine M. Snijders Jian-Hua Mao Hang Chang Bo Hang
author_facet	Li He Pin Wang Suzyann F. Schick Abel Huang Peyton Jacob Xu Yang Yankai Xia Antoine M. Snijders Jian-Hua Mao Hang Chang Bo Hang
author_sort	Li He
title	Genetic background influences the effect of thirdhand smoke exposure on anxiety and memory in Collaborative Cross mice
title_short	Genetic background influences the effect of thirdhand smoke exposure on anxiety and memory in Collaborative Cross mice
title_full	Genetic background influences the effect of thirdhand smoke exposure on anxiety and memory in Collaborative Cross mice
title_fullStr	Genetic background influences the effect of thirdhand smoke exposure on anxiety and memory in Collaborative Cross mice
title_full_unstemmed	Genetic background influences the effect of thirdhand smoke exposure on anxiety and memory in Collaborative Cross mice
title_sort	genetic background influences the effect of thirdhand smoke exposure on anxiety and memory in collaborative cross mice
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8f0ef1011a3745c9a7612040e1d18c2c
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Genetic background influences the effect of thirdhand smoke exposure on anxiety and memory in Collaborative Cross mice

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