Salvage of the 5-deoxyribose byproduct of radical SAM enzymes

5-Deoxyribose is formed from 5′-deoxyadenosine, a toxic byproduct of radical S-adenosylmethionine enzymes. Here, the authors identify and biochemically characterize a bacterial salvage pathway for 5-deoxyribose, consisting of three enzymes, and solve the crystal structure of the key aldolase.

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Autores principales:	Guillaume A. W. Beaudoin, Qiang Li, Jacob Folz, Oliver Fiehn, Justin L. Goodsell, Alexander Angerhofer, Steven D. Bruner, Andrew D. Hanson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8f102546de1241ed9baef7187af4175b
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spelling	oai:doaj.org-article:8f102546de1241ed9baef7187af4175b2021-12-02T17:32:02ZSalvage of the 5-deoxyribose byproduct of radical SAM enzymes10.1038/s41467-018-05589-42041-1723https://doaj.org/article/8f102546de1241ed9baef7187af4175b2018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05589-4https://doaj.org/toc/2041-17235-Deoxyribose is formed from 5′-deoxyadenosine, a toxic byproduct of radical S-adenosylmethionine enzymes. Here, the authors identify and biochemically characterize a bacterial salvage pathway for 5-deoxyribose, consisting of three enzymes, and solve the crystal structure of the key aldolase.Guillaume A. W. BeaudoinQiang LiJacob FolzOliver FiehnJustin L. GoodsellAlexander AngerhoferSteven D. BrunerAndrew D. HansonNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Guillaume A. W. Beaudoin Qiang Li Jacob Folz Oliver Fiehn Justin L. Goodsell Alexander Angerhofer Steven D. Bruner Andrew D. Hanson Salvage of the 5-deoxyribose byproduct of radical SAM enzymes
description	5-Deoxyribose is formed from 5′-deoxyadenosine, a toxic byproduct of radical S-adenosylmethionine enzymes. Here, the authors identify and biochemically characterize a bacterial salvage pathway for 5-deoxyribose, consisting of three enzymes, and solve the crystal structure of the key aldolase.
format	article
author	Guillaume A. W. Beaudoin Qiang Li Jacob Folz Oliver Fiehn Justin L. Goodsell Alexander Angerhofer Steven D. Bruner Andrew D. Hanson
author_facet	Guillaume A. W. Beaudoin Qiang Li Jacob Folz Oliver Fiehn Justin L. Goodsell Alexander Angerhofer Steven D. Bruner Andrew D. Hanson
author_sort	Guillaume A. W. Beaudoin
title	Salvage of the 5-deoxyribose byproduct of radical SAM enzymes
title_short	Salvage of the 5-deoxyribose byproduct of radical SAM enzymes
title_full	Salvage of the 5-deoxyribose byproduct of radical SAM enzymes
title_fullStr	Salvage of the 5-deoxyribose byproduct of radical SAM enzymes
title_full_unstemmed	Salvage of the 5-deoxyribose byproduct of radical SAM enzymes
title_sort	salvage of the 5-deoxyribose byproduct of radical sam enzymes
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/8f102546de1241ed9baef7187af4175b
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Salvage of the 5-deoxyribose byproduct of radical SAM enzymes

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