RUNX1 and REXO2 are associated with the heterogeneity and prognosis of IDH wild type lower grade glioma

Abstract Based on isocitrate dehydrogenase (IDH) alterations, lower grade glioma (LGG) is divided into IDH mutant and wild type subgroups. However, the further classification of IDH wild type LGG was unclear. Here, IDH wild type LGG patients in The Cancer Genome Atlas and Chinese Glioma Genome Atlas...

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Autores principales:	Haiwei Wang, Xinrui Wang, Liangpu Xu, Ji Zhang, Hua Cao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8f12b7af975c4c59850bd6361bfd2ce4
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spelling	oai:doaj.org-article:8f12b7af975c4c59850bd6361bfd2ce42021-12-02T15:02:40ZRUNX1 and REXO2 are associated with the heterogeneity and prognosis of IDH wild type lower grade glioma10.1038/s41598-021-91382-12045-2322https://doaj.org/article/8f12b7af975c4c59850bd6361bfd2ce42021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91382-1https://doaj.org/toc/2045-2322Abstract Based on isocitrate dehydrogenase (IDH) alterations, lower grade glioma (LGG) is divided into IDH mutant and wild type subgroups. However, the further classification of IDH wild type LGG was unclear. Here, IDH wild type LGG patients in The Cancer Genome Atlas and Chinese Glioma Genome Atlas were divided into two sub-clusters using non-negative matrix factorization. IDH wild type LGG patients in sub-cluster2 had prolonged overall survival and low frequency of CDKN2A alterations and low immune infiltrations. Differentially expressed genes in sub-cluster1 were positively correlated with RUNX1 transcription factor. Moreover, IDH wild type LGG patients with higher stromal score or immune score were positively correlated with RUNX1 transcription factor. RUNX1 and its target gene REXO2 were up-regulated in sub-cluster1 and associated with the worse prognosis of IDH wild type LGG. RUNX1 and REXO2 were associated with the higher immune infiltrations. Furthermore, RUNX1 and REXO2 were correlated with the worse prognosis of LGG or glioma. IDH wild type LGG in sub-cluster2 was hyper-methylated. REXO2 hyper-methylation was associated with the favorable prognosis of LGG or glioma. At last, we showed that, age, tumor grade and REXO2 expression were independent prognostic factors in IDH wild type LGG.Haiwei WangXinrui WangLiangpu XuJi ZhangHua CaoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Haiwei Wang Xinrui Wang Liangpu Xu Ji Zhang Hua Cao RUNX1 and REXO2 are associated with the heterogeneity and prognosis of IDH wild type lower grade glioma
description	Abstract Based on isocitrate dehydrogenase (IDH) alterations, lower grade glioma (LGG) is divided into IDH mutant and wild type subgroups. However, the further classification of IDH wild type LGG was unclear. Here, IDH wild type LGG patients in The Cancer Genome Atlas and Chinese Glioma Genome Atlas were divided into two sub-clusters using non-negative matrix factorization. IDH wild type LGG patients in sub-cluster2 had prolonged overall survival and low frequency of CDKN2A alterations and low immune infiltrations. Differentially expressed genes in sub-cluster1 were positively correlated with RUNX1 transcription factor. Moreover, IDH wild type LGG patients with higher stromal score or immune score were positively correlated with RUNX1 transcription factor. RUNX1 and its target gene REXO2 were up-regulated in sub-cluster1 and associated with the worse prognosis of IDH wild type LGG. RUNX1 and REXO2 were associated with the higher immune infiltrations. Furthermore, RUNX1 and REXO2 were correlated with the worse prognosis of LGG or glioma. IDH wild type LGG in sub-cluster2 was hyper-methylated. REXO2 hyper-methylation was associated with the favorable prognosis of LGG or glioma. At last, we showed that, age, tumor grade and REXO2 expression were independent prognostic factors in IDH wild type LGG.
format	article
author	Haiwei Wang Xinrui Wang Liangpu Xu Ji Zhang Hua Cao
author_facet	Haiwei Wang Xinrui Wang Liangpu Xu Ji Zhang Hua Cao
author_sort	Haiwei Wang
title	RUNX1 and REXO2 are associated with the heterogeneity and prognosis of IDH wild type lower grade glioma
title_short	RUNX1 and REXO2 are associated with the heterogeneity and prognosis of IDH wild type lower grade glioma
title_full	RUNX1 and REXO2 are associated with the heterogeneity and prognosis of IDH wild type lower grade glioma
title_fullStr	RUNX1 and REXO2 are associated with the heterogeneity and prognosis of IDH wild type lower grade glioma
title_full_unstemmed	RUNX1 and REXO2 are associated with the heterogeneity and prognosis of IDH wild type lower grade glioma
title_sort	runx1 and rexo2 are associated with the heterogeneity and prognosis of idh wild type lower grade glioma
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8f12b7af975c4c59850bd6361bfd2ce4
work_keys_str_mv	AT haiweiwang runx1andrexo2areassociatedwiththeheterogeneityandprognosisofidhwildtypelowergradeglioma AT xinruiwang runx1andrexo2areassociatedwiththeheterogeneityandprognosisofidhwildtypelowergradeglioma AT liangpuxu runx1andrexo2areassociatedwiththeheterogeneityandprognosisofidhwildtypelowergradeglioma AT jizhang runx1andrexo2areassociatedwiththeheterogeneityandprognosisofidhwildtypelowergradeglioma AT huacao runx1andrexo2areassociatedwiththeheterogeneityandprognosisofidhwildtypelowergradeglioma
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RUNX1 and REXO2 are associated with the heterogeneity and prognosis of IDH wild type lower grade glioma

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