Transient global amnesia: current perspectives

David R Spiegel, Justin Smith, Ryan R Wade, Nithya Cherukuru, Aneel Ursani, Yuliya Dobruskina, Taylor Crist, Robert F Busch, Rahim M Dhanani, Nicholas Dreyer Department of Psychiatry and Behavioral Sciences, Eastern Virginia Medical School, Norfolk, VA, USA Abstract: Transient global amnesia (TGA)...

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Autores principales:	Spiegel DR, Smith J, Wade RR, Cherukuru N, Ursani A, Dobruskina Y, Crist T, Busch RF, Dhanani RM, Dreyer N
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Transient Global Amnesia Vascular Migraines Psychiatric Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/8f1373e56e85444d872fa8f127ececb5
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spelling	oai:doaj.org-article:8f1373e56e85444d872fa8f127ececb52021-12-02T01:22:30ZTransient global amnesia: current perspectives1178-2021https://doaj.org/article/8f1373e56e85444d872fa8f127ececb52017-10-01T00:00:00Zhttps://www.dovepress.com/transient-global-amnesia-current-perspectives-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021David R Spiegel, Justin Smith, Ryan R Wade, Nithya Cherukuru, Aneel Ursani, Yuliya Dobruskina, Taylor Crist, Robert F Busch, Rahim M Dhanani, Nicholas Dreyer Department of Psychiatry and Behavioral Sciences, Eastern Virginia Medical School, Norfolk, VA, USA Abstract: Transient global amnesia (TGA) is a clinical syndrome characterized by the sudden onset of an extraordinarily large reduction of anterograde and a somewhat milder reduction of retrograde episodic long-term memory. Additionally, executive functions are described as diminished. Although it is suggested that various factors, such as migraine, focal ischemia, venous flow abnormalities, and epileptic phenomena, are involved in the pathophysiology and differential diagnosis of TGA, the factors triggering the emergence of these lesions are still elusive. Recent data suggest that the vulnerability of CA1 neurons to metabolic stress plays a pivotal part in the pathophysiological cascade, leading to an impairment of hippocampal function during TGA. In this review, we discuss clinical aspects, new imaging findings, and recent clinical–epidemiological data with regard to the phenotype, functional anatomy, and putative cellular mechanisms of TGA. Keywords: transient global amnesia, vascular, migraines, psychiatricSpiegel DRSmith JWade RRCherukuru NUrsani ADobruskina YCrist TBusch RFDhanani RMDreyer NDove Medical PressarticleTransient Global AmnesiaVascularMigrainesPsychiatricNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 13, Pp 2691-2703 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Transient Global Amnesia Vascular Migraines Psychiatric Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Transient Global Amnesia Vascular Migraines Psychiatric Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Spiegel DR Smith J Wade RR Cherukuru N Ursani A Dobruskina Y Crist T Busch RF Dhanani RM Dreyer N Transient global amnesia: current perspectives
description	David R Spiegel, Justin Smith, Ryan R Wade, Nithya Cherukuru, Aneel Ursani, Yuliya Dobruskina, Taylor Crist, Robert F Busch, Rahim M Dhanani, Nicholas Dreyer Department of Psychiatry and Behavioral Sciences, Eastern Virginia Medical School, Norfolk, VA, USA Abstract: Transient global amnesia (TGA) is a clinical syndrome characterized by the sudden onset of an extraordinarily large reduction of anterograde and a somewhat milder reduction of retrograde episodic long-term memory. Additionally, executive functions are described as diminished. Although it is suggested that various factors, such as migraine, focal ischemia, venous flow abnormalities, and epileptic phenomena, are involved in the pathophysiology and differential diagnosis of TGA, the factors triggering the emergence of these lesions are still elusive. Recent data suggest that the vulnerability of CA1 neurons to metabolic stress plays a pivotal part in the pathophysiological cascade, leading to an impairment of hippocampal function during TGA. In this review, we discuss clinical aspects, new imaging findings, and recent clinical–epidemiological data with regard to the phenotype, functional anatomy, and putative cellular mechanisms of TGA. Keywords: transient global amnesia, vascular, migraines, psychiatric
format	article
author	Spiegel DR Smith J Wade RR Cherukuru N Ursani A Dobruskina Y Crist T Busch RF Dhanani RM Dreyer N
author_facet	Spiegel DR Smith J Wade RR Cherukuru N Ursani A Dobruskina Y Crist T Busch RF Dhanani RM Dreyer N
author_sort	Spiegel DR
title	Transient global amnesia: current perspectives
title_short	Transient global amnesia: current perspectives
title_full	Transient global amnesia: current perspectives
title_fullStr	Transient global amnesia: current perspectives
title_full_unstemmed	Transient global amnesia: current perspectives
title_sort	transient global amnesia: current perspectives
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/8f1373e56e85444d872fa8f127ececb5
work_keys_str_mv	AT spiegeldr transientglobalamnesiacurrentperspectives AT smithj transientglobalamnesiacurrentperspectives AT waderr transientglobalamnesiacurrentperspectives AT cherukurun transientglobalamnesiacurrentperspectives AT ursania transientglobalamnesiacurrentperspectives AT dobruskinay transientglobalamnesiacurrentperspectives AT cristt transientglobalamnesiacurrentperspectives AT buschrf transientglobalamnesiacurrentperspectives AT dhananirm transientglobalamnesiacurrentperspectives AT dreyern transientglobalamnesiacurrentperspectives
_version_	1718403151047950336

Transient global amnesia: current perspectives

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