Circadian Clock Model Supports Molecular Link Between PER3 and Human Anxiety

Abstract Generalized anxiety and major depression have become increasingly common in the United States, affecting 18.6 percent of the adult population. Mood disorders can be debilitating, and are often correlated with poor general health, life dissatisfaction, and the need for disability benefits du...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Amanda R. Liberman, Soo Bin Kwon, Ha T. Vu, Allan Filipowicz, Ahmet Ay, Krista K. Ingram
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8f15de007ce3456db03c89173226d3f2
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:8f15de007ce3456db03c89173226d3f2
record_format	dspace
spelling	oai:doaj.org-article:8f15de007ce3456db03c89173226d3f22021-12-02T15:06:04ZCircadian Clock Model Supports Molecular Link Between PER3 and Human Anxiety10.1038/s41598-017-07957-42045-2322https://doaj.org/article/8f15de007ce3456db03c89173226d3f22017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-07957-4https://doaj.org/toc/2045-2322Abstract Generalized anxiety and major depression have become increasingly common in the United States, affecting 18.6 percent of the adult population. Mood disorders can be debilitating, and are often correlated with poor general health, life dissatisfaction, and the need for disability benefits due to inability to work. Recent evidence suggests that some mood disorders have a circadian component, and disruptions in circadian rhythms may even trigger the development of these disorders. However, the molecular mechanisms of this interaction are not well understood. Polymorphisms in a circadian clock-related gene, PER3, are associated with behavioral phenotypes (extreme diurnal preference in arousal and activity) and sleep/mood disorders, including seasonal affective disorder (SAD). Here we show that two PER3 mutations, a variable number tandem repeat (VNTR) allele and a single-nucleotide polymorphism (SNP), are associated with diurnal preference and higher Trait-Anxiety scores, supporting a role for PER3 in mood modulation. In addition, we explore a potential mechanism for how PER3 influences mood by utilizing a comprehensive circadian clock model that accurately predicts the changes in circadian period evident in knock-out phenotypes and individuals with PER3-related clock disorders.Amanda R. LibermanSoo Bin KwonHa T. VuAllan FilipowiczAhmet AyKrista K. IngramNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Amanda R. Liberman Soo Bin Kwon Ha T. Vu Allan Filipowicz Ahmet Ay Krista K. Ingram Circadian Clock Model Supports Molecular Link Between PER3 and Human Anxiety
description	Abstract Generalized anxiety and major depression have become increasingly common in the United States, affecting 18.6 percent of the adult population. Mood disorders can be debilitating, and are often correlated with poor general health, life dissatisfaction, and the need for disability benefits due to inability to work. Recent evidence suggests that some mood disorders have a circadian component, and disruptions in circadian rhythms may even trigger the development of these disorders. However, the molecular mechanisms of this interaction are not well understood. Polymorphisms in a circadian clock-related gene, PER3, are associated with behavioral phenotypes (extreme diurnal preference in arousal and activity) and sleep/mood disorders, including seasonal affective disorder (SAD). Here we show that two PER3 mutations, a variable number tandem repeat (VNTR) allele and a single-nucleotide polymorphism (SNP), are associated with diurnal preference and higher Trait-Anxiety scores, supporting a role for PER3 in mood modulation. In addition, we explore a potential mechanism for how PER3 influences mood by utilizing a comprehensive circadian clock model that accurately predicts the changes in circadian period evident in knock-out phenotypes and individuals with PER3-related clock disorders.
format	article
author	Amanda R. Liberman Soo Bin Kwon Ha T. Vu Allan Filipowicz Ahmet Ay Krista K. Ingram
author_facet	Amanda R. Liberman Soo Bin Kwon Ha T. Vu Allan Filipowicz Ahmet Ay Krista K. Ingram
author_sort	Amanda R. Liberman
title	Circadian Clock Model Supports Molecular Link Between PER3 and Human Anxiety
title_short	Circadian Clock Model Supports Molecular Link Between PER3 and Human Anxiety
title_full	Circadian Clock Model Supports Molecular Link Between PER3 and Human Anxiety
title_fullStr	Circadian Clock Model Supports Molecular Link Between PER3 and Human Anxiety
title_full_unstemmed	Circadian Clock Model Supports Molecular Link Between PER3 and Human Anxiety
title_sort	circadian clock model supports molecular link between per3 and human anxiety
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/8f15de007ce3456db03c89173226d3f2
work_keys_str_mv	AT amandarliberman circadianclockmodelsupportsmolecularlinkbetweenper3andhumananxiety AT soobinkwon circadianclockmodelsupportsmolecularlinkbetweenper3andhumananxiety AT hatvu circadianclockmodelsupportsmolecularlinkbetweenper3andhumananxiety AT allanfilipowicz circadianclockmodelsupportsmolecularlinkbetweenper3andhumananxiety AT ahmetay circadianclockmodelsupportsmolecularlinkbetweenper3andhumananxiety AT kristakingram circadianclockmodelsupportsmolecularlinkbetweenper3andhumananxiety
_version_	1718388596688289792

Circadian Clock Model Supports Molecular Link Between PER3 and Human Anxiety

Ejemplares similares