MLL1 is required for PAX7 expression and satellite cell self-renewal in mice

PAX7 transcription factor specifies the myogenic identity of muscle stem cells and acts as a nodal factor by stimulating proliferation while inhibiting differentiation. Here authors find that Mll1 deletion in myoblasts in mice results in reduced H3K4me3 at both Pax7 and Myf5 promoters, reduced Pax7...

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Main Authors:	Gregory C. Addicks, Caroline E. Brun, Marie-Claude Sincennes, John Saber, Christopher J. Porter, A. Francis Stewart, Patricia Ernst, Michael A. Rudnicki
Format:	article
Language:	EN
Published:	Nature Portfolio 2019
Subjects:	Science Q
Online Access:	https://doaj.org/article/8f1a223e30424b10ab115c2947e3f185
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id	oai:doaj.org-article:8f1a223e30424b10ab115c2947e3f185
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spelling	oai:doaj.org-article:8f1a223e30424b10ab115c2947e3f1852021-12-02T16:57:30ZMLL1 is required for PAX7 expression and satellite cell self-renewal in mice10.1038/s41467-019-12086-92041-1723https://doaj.org/article/8f1a223e30424b10ab115c2947e3f1852019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12086-9https://doaj.org/toc/2041-1723PAX7 transcription factor specifies the myogenic identity of muscle stem cells and acts as a nodal factor by stimulating proliferation while inhibiting differentiation. Here authors find that Mll1 deletion in myoblasts in mice results in reduced H3K4me3 at both Pax7 and Myf5 promoters, reduced Pax7 and Myf5 expression, and proliferation defects.Gregory C. AddicksCaroline E. BrunMarie-Claude SincennesJohn SaberChristopher J. PorterA. Francis StewartPatricia ErnstMichael A. RudnickiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Gregory C. Addicks Caroline E. Brun Marie-Claude Sincennes John Saber Christopher J. Porter A. Francis Stewart Patricia Ernst Michael A. Rudnicki MLL1 is required for PAX7 expression and satellite cell self-renewal in mice
description	PAX7 transcription factor specifies the myogenic identity of muscle stem cells and acts as a nodal factor by stimulating proliferation while inhibiting differentiation. Here authors find that Mll1 deletion in myoblasts in mice results in reduced H3K4me3 at both Pax7 and Myf5 promoters, reduced Pax7 and Myf5 expression, and proliferation defects.
format	article
author	Gregory C. Addicks Caroline E. Brun Marie-Claude Sincennes John Saber Christopher J. Porter A. Francis Stewart Patricia Ernst Michael A. Rudnicki
author_facet	Gregory C. Addicks Caroline E. Brun Marie-Claude Sincennes John Saber Christopher J. Porter A. Francis Stewart Patricia Ernst Michael A. Rudnicki
author_sort	Gregory C. Addicks
title	MLL1 is required for PAX7 expression and satellite cell self-renewal in mice
title_short	MLL1 is required for PAX7 expression and satellite cell self-renewal in mice
title_full	MLL1 is required for PAX7 expression and satellite cell self-renewal in mice
title_fullStr	MLL1 is required for PAX7 expression and satellite cell self-renewal in mice
title_full_unstemmed	MLL1 is required for PAX7 expression and satellite cell self-renewal in mice
title_sort	mll1 is required for pax7 expression and satellite cell self-renewal in mice
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/8f1a223e30424b10ab115c2947e3f185
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MLL1 is required for PAX7 expression and satellite cell self-renewal in mice

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