MLL1 is required for PAX7 expression and satellite cell self-renewal in mice

PAX7 transcription factor specifies the myogenic identity of muscle stem cells and acts as a nodal factor by stimulating proliferation while inhibiting differentiation. Here authors find that Mll1 deletion in myoblasts in mice results in reduced H3K4me3 at both Pax7 and Myf5 promoters, reduced Pax7...

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Autores principales: Gregory C. Addicks, Caroline E. Brun, Marie-Claude Sincennes, John Saber, Christopher J. Porter, A. Francis Stewart, Patricia Ernst, Michael A. Rudnicki
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/8f1a223e30424b10ab115c2947e3f185
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spelling oai:doaj.org-article:8f1a223e30424b10ab115c2947e3f1852021-12-02T16:57:30ZMLL1 is required for PAX7 expression and satellite cell self-renewal in mice10.1038/s41467-019-12086-92041-1723https://doaj.org/article/8f1a223e30424b10ab115c2947e3f1852019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12086-9https://doaj.org/toc/2041-1723PAX7 transcription factor specifies the myogenic identity of muscle stem cells and acts as a nodal factor by stimulating proliferation while inhibiting differentiation. Here authors find that Mll1 deletion in myoblasts in mice results in reduced H3K4me3 at both Pax7 and Myf5 promoters, reduced Pax7 and Myf5 expression, and proliferation defects.Gregory C. AddicksCaroline E. BrunMarie-Claude SincennesJohn SaberChristopher J. PorterA. Francis StewartPatricia ErnstMichael A. RudnickiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Gregory C. Addicks
Caroline E. Brun
Marie-Claude Sincennes
John Saber
Christopher J. Porter
A. Francis Stewart
Patricia Ernst
Michael A. Rudnicki
MLL1 is required for PAX7 expression and satellite cell self-renewal in mice
description PAX7 transcription factor specifies the myogenic identity of muscle stem cells and acts as a nodal factor by stimulating proliferation while inhibiting differentiation. Here authors find that Mll1 deletion in myoblasts in mice results in reduced H3K4me3 at both Pax7 and Myf5 promoters, reduced Pax7 and Myf5 expression, and proliferation defects.
format article
author Gregory C. Addicks
Caroline E. Brun
Marie-Claude Sincennes
John Saber
Christopher J. Porter
A. Francis Stewart
Patricia Ernst
Michael A. Rudnicki
author_facet Gregory C. Addicks
Caroline E. Brun
Marie-Claude Sincennes
John Saber
Christopher J. Porter
A. Francis Stewart
Patricia Ernst
Michael A. Rudnicki
author_sort Gregory C. Addicks
title MLL1 is required for PAX7 expression and satellite cell self-renewal in mice
title_short MLL1 is required for PAX7 expression and satellite cell self-renewal in mice
title_full MLL1 is required for PAX7 expression and satellite cell self-renewal in mice
title_fullStr MLL1 is required for PAX7 expression and satellite cell self-renewal in mice
title_full_unstemmed MLL1 is required for PAX7 expression and satellite cell self-renewal in mice
title_sort mll1 is required for pax7 expression and satellite cell self-renewal in mice
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/8f1a223e30424b10ab115c2947e3f185
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