MLL1 is required for PAX7 expression and satellite cell self-renewal in mice
PAX7 transcription factor specifies the myogenic identity of muscle stem cells and acts as a nodal factor by stimulating proliferation while inhibiting differentiation. Here authors find that Mll1 deletion in myoblasts in mice results in reduced H3K4me3 at both Pax7 and Myf5 promoters, reduced Pax7...
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Nature Portfolio
2019
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oai:doaj.org-article:8f1a223e30424b10ab115c2947e3f1852021-12-02T16:57:30ZMLL1 is required for PAX7 expression and satellite cell self-renewal in mice10.1038/s41467-019-12086-92041-1723https://doaj.org/article/8f1a223e30424b10ab115c2947e3f1852019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12086-9https://doaj.org/toc/2041-1723PAX7 transcription factor specifies the myogenic identity of muscle stem cells and acts as a nodal factor by stimulating proliferation while inhibiting differentiation. Here authors find that Mll1 deletion in myoblasts in mice results in reduced H3K4me3 at both Pax7 and Myf5 promoters, reduced Pax7 and Myf5 expression, and proliferation defects.Gregory C. AddicksCaroline E. BrunMarie-Claude SincennesJohn SaberChristopher J. PorterA. Francis StewartPatricia ErnstMichael A. RudnickiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019) |
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Science Q Gregory C. Addicks Caroline E. Brun Marie-Claude Sincennes John Saber Christopher J. Porter A. Francis Stewart Patricia Ernst Michael A. Rudnicki MLL1 is required for PAX7 expression and satellite cell self-renewal in mice |
description |
PAX7 transcription factor specifies the myogenic identity of muscle stem cells and acts as a nodal factor by stimulating proliferation while inhibiting differentiation. Here authors find that Mll1 deletion in myoblasts in mice results in reduced H3K4me3 at both Pax7 and Myf5 promoters, reduced Pax7 and Myf5 expression, and proliferation defects. |
format |
article |
author |
Gregory C. Addicks Caroline E. Brun Marie-Claude Sincennes John Saber Christopher J. Porter A. Francis Stewart Patricia Ernst Michael A. Rudnicki |
author_facet |
Gregory C. Addicks Caroline E. Brun Marie-Claude Sincennes John Saber Christopher J. Porter A. Francis Stewart Patricia Ernst Michael A. Rudnicki |
author_sort |
Gregory C. Addicks |
title |
MLL1 is required for PAX7 expression and satellite cell self-renewal in mice |
title_short |
MLL1 is required for PAX7 expression and satellite cell self-renewal in mice |
title_full |
MLL1 is required for PAX7 expression and satellite cell self-renewal in mice |
title_fullStr |
MLL1 is required for PAX7 expression and satellite cell self-renewal in mice |
title_full_unstemmed |
MLL1 is required for PAX7 expression and satellite cell self-renewal in mice |
title_sort |
mll1 is required for pax7 expression and satellite cell self-renewal in mice |
publisher |
Nature Portfolio |
publishDate |
2019 |
url |
https://doaj.org/article/8f1a223e30424b10ab115c2947e3f185 |
work_keys_str_mv |
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