MLL1 is required for PAX7 expression and satellite cell self-renewal in mice

MLL1 is required for PAX7 expression and satellite cell self-renewal in mice

PAX7 transcription factor specifies the myogenic identity of muscle stem cells and acts as a nodal factor by stimulating proliferation while inhibiting differentiation. Here authors find that Mll1 deletion in myoblasts in mice results in reduced H3K4me3 at both Pax7 and Myf5 promoters, reduced Pax7...

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Autores principales: Gregory C. Addicks, Caroline E. Brun, Marie-Claude Sincennes, John Saber, Christopher J. Porter, A. Francis Stewart, Patricia Ernst, Michael A. Rudnicki
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Science
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Acceso en línea:https://doaj.org/article/8f1a223e30424b10ab115c2947e3f185
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