Time-Dependent Hypoglycemic and Hypolipidemic Effect of Allium Ascalonicum L. Feeding in Diabetic Rats

BACKGROUND AND OBJECTIVE: Diabetes mellitus is one the most important risk factors for some disorders. Reduction of serum glucose and lipid levels in diabetic patients due to medicinal plants is clinically important. The aim of this study was to evaluate time-dependent anti-diabetic effect of Allium...

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Autores principales:	F Fallahi, M Roghani, A Bagheri
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2010
Materias:	allium ascalonicum diabetes mellitus hypoglycemic hypolipidemic Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/8f1d78ba814646f78eca150b5e70840d
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spelling	oai:doaj.org-article:8f1d78ba814646f78eca150b5e70840d2021-11-10T09:00:14ZTime-Dependent Hypoglycemic and Hypolipidemic Effect of Allium Ascalonicum L. Feeding in Diabetic Rats1561-41072251-7170https://doaj.org/article/8f1d78ba814646f78eca150b5e70840d2010-04-01T00:00:00Zhttp://jbums.org/article-1-3407-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170BACKGROUND AND OBJECTIVE: Diabetes mellitus is one the most important risk factors for some disorders. Reduction of serum glucose and lipid levels in diabetic patients due to medicinal plants is clinically important. The aim of this study was to evaluate time-dependent anti-diabetic effect of Allium ascalonicum L. (AA) feeding.METHODS: In this experimental study, 40 male Wistar rats (250-350 g) were divided into 4 groups, i.e. control, AA-treated control, diabetic, and AA-treated diabetic groups. The treatment groups received oral administration of plant-mixed pelleted food for 8 weeks. Streptozotocin (60 mg/kg) was used for diabetes induction. Serum glucose and lipids levels were determined before the study, and at 4th and 8th weeks after the study using routine enzymatic methods.FINDINGS: Serum glucose was significantly lower (29.8% and 56.2%) in AA-treated diabetic rats at 4th and 8th week as compared to untreated diabetics (p<0.01; p<0.005). In addition, serum total cholesterol showed a significant reduction (38.3% and 47.1%) at 4th and 8th weeks in AA-treated diabetic rats as compared to untreated diabetics (p<0.01). There was also a significant lower level of triglyceride (30.9%) in AA-treated diabetic rats (p<0.05) only at 8th week. On the other hand, although AA treatment did not cause a significant improvement in HDL-cholesterol level in treated diabetic group as compared to untreated diabetic group, but a significant lower level of LDL-cholesterol at 4th and 8th weeks (39.1% and 42.5%) was observed in AA-treated diabetics (p<0.01) relative to untreated diabetics.CONCLUSION: Oral administration of AA time-dependently has a significant hypoglycemic effect and improves lipid profile except for HDL-cholesterol.F Fallahi,M Roghani,A BagheriBabol University of Medical Sciencesarticleallium ascalonicumdiabetes mellitushypoglycemichypolipidemicMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 12, Iss 1, Pp 16-23 (2010)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	allium ascalonicum diabetes mellitus hypoglycemic hypolipidemic Medicine R Medicine (General) R5-920
spellingShingle	allium ascalonicum diabetes mellitus hypoglycemic hypolipidemic Medicine R Medicine (General) R5-920 F Fallahi, M Roghani, A Bagheri Time-Dependent Hypoglycemic and Hypolipidemic Effect of Allium Ascalonicum L. Feeding in Diabetic Rats
description	BACKGROUND AND OBJECTIVE: Diabetes mellitus is one the most important risk factors for some disorders. Reduction of serum glucose and lipid levels in diabetic patients due to medicinal plants is clinically important. The aim of this study was to evaluate time-dependent anti-diabetic effect of Allium ascalonicum L. (AA) feeding.METHODS: In this experimental study, 40 male Wistar rats (250-350 g) were divided into 4 groups, i.e. control, AA-treated control, diabetic, and AA-treated diabetic groups. The treatment groups received oral administration of plant-mixed pelleted food for 8 weeks. Streptozotocin (60 mg/kg) was used for diabetes induction. Serum glucose and lipids levels were determined before the study, and at 4th and 8th weeks after the study using routine enzymatic methods.FINDINGS: Serum glucose was significantly lower (29.8% and 56.2%) in AA-treated diabetic rats at 4th and 8th week as compared to untreated diabetics (p<0.01; p<0.005). In addition, serum total cholesterol showed a significant reduction (38.3% and 47.1%) at 4th and 8th weeks in AA-treated diabetic rats as compared to untreated diabetics (p<0.01). There was also a significant lower level of triglyceride (30.9%) in AA-treated diabetic rats (p<0.05) only at 8th week. On the other hand, although AA treatment did not cause a significant improvement in HDL-cholesterol level in treated diabetic group as compared to untreated diabetic group, but a significant lower level of LDL-cholesterol at 4th and 8th weeks (39.1% and 42.5%) was observed in AA-treated diabetics (p<0.01) relative to untreated diabetics.CONCLUSION: Oral administration of AA time-dependently has a significant hypoglycemic effect and improves lipid profile except for HDL-cholesterol.
format	article
author	F Fallahi, M Roghani, A Bagheri
author_facet	F Fallahi, M Roghani, A Bagheri
author_sort	F Fallahi,
title	Time-Dependent Hypoglycemic and Hypolipidemic Effect of Allium Ascalonicum L. Feeding in Diabetic Rats
title_short	Time-Dependent Hypoglycemic and Hypolipidemic Effect of Allium Ascalonicum L. Feeding in Diabetic Rats
title_full	Time-Dependent Hypoglycemic and Hypolipidemic Effect of Allium Ascalonicum L. Feeding in Diabetic Rats
title_fullStr	Time-Dependent Hypoglycemic and Hypolipidemic Effect of Allium Ascalonicum L. Feeding in Diabetic Rats
title_full_unstemmed	Time-Dependent Hypoglycemic and Hypolipidemic Effect of Allium Ascalonicum L. Feeding in Diabetic Rats
title_sort	time-dependent hypoglycemic and hypolipidemic effect of allium ascalonicum l. feeding in diabetic rats
publisher	Babol University of Medical Sciences
publishDate	2010
url	https://doaj.org/article/8f1d78ba814646f78eca150b5e70840d
work_keys_str_mv	AT ffallahi timedependenthypoglycemicandhypolipidemiceffectofalliumascalonicumlfeedingindiabeticrats AT mroghani timedependenthypoglycemicandhypolipidemiceffectofalliumascalonicumlfeedingindiabeticrats AT abagheri timedependenthypoglycemicandhypolipidemiceffectofalliumascalonicumlfeedingindiabeticrats
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Time-Dependent Hypoglycemic and Hypolipidemic Effect of Allium Ascalonicum L. Feeding in Diabetic Rats

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