Pharmacological but not physiological GDF15 suppresses feeding and the motivation to exercise
The physiological role of GDF15 remains poorly defined. Here, the authors show that circulating GDF15 increases in response to prolonged exercise, but that this exercise-induced GDF15, unlike pharmacological GDF15, does not affect post-exercise food intake or exercise motivation.
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Nature Portfolio
2021
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oai:doaj.org-article:8f1d9eea4091471ca84ea46086fb76362021-12-02T10:54:12ZPharmacological but not physiological GDF15 suppresses feeding and the motivation to exercise10.1038/s41467-021-21309-x2041-1723https://doaj.org/article/8f1d9eea4091471ca84ea46086fb76362021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21309-xhttps://doaj.org/toc/2041-1723The physiological role of GDF15 remains poorly defined. Here, the authors show that circulating GDF15 increases in response to prolonged exercise, but that this exercise-induced GDF15, unlike pharmacological GDF15, does not affect post-exercise food intake or exercise motivation.Anders B. KleinTrine S. NicolaisenNiels ØrtenbladKasper D. GejlRasmus JensenAndreas M. FritzenEmil L. LarsenKristian KarstoftHenrik E. PoulsenThomas MorvilleRonni E. SahlJørn W. HelgeJens LundSarah FalkMark LyngbækHelga EllingsgaardBente K. PedersenWei LuBrian FinanSebastian B. JørgensenRandy J. SeeleyMaximilian KleinertBente KiensErik A. RichterChristoffer ClemmensenNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-9 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Anders B. Klein Trine S. Nicolaisen Niels Ørtenblad Kasper D. Gejl Rasmus Jensen Andreas M. Fritzen Emil L. Larsen Kristian Karstoft Henrik E. Poulsen Thomas Morville Ronni E. Sahl Jørn W. Helge Jens Lund Sarah Falk Mark Lyngbæk Helga Ellingsgaard Bente K. Pedersen Wei Lu Brian Finan Sebastian B. Jørgensen Randy J. Seeley Maximilian Kleinert Bente Kiens Erik A. Richter Christoffer Clemmensen Pharmacological but not physiological GDF15 suppresses feeding and the motivation to exercise |
| description |
The physiological role of GDF15 remains poorly defined. Here, the authors show that circulating GDF15 increases in response to prolonged exercise, but that this exercise-induced GDF15, unlike pharmacological GDF15, does not affect post-exercise food intake or exercise motivation. |
| format |
article |
| author |
Anders B. Klein Trine S. Nicolaisen Niels Ørtenblad Kasper D. Gejl Rasmus Jensen Andreas M. Fritzen Emil L. Larsen Kristian Karstoft Henrik E. Poulsen Thomas Morville Ronni E. Sahl Jørn W. Helge Jens Lund Sarah Falk Mark Lyngbæk Helga Ellingsgaard Bente K. Pedersen Wei Lu Brian Finan Sebastian B. Jørgensen Randy J. Seeley Maximilian Kleinert Bente Kiens Erik A. Richter Christoffer Clemmensen |
| author_facet |
Anders B. Klein Trine S. Nicolaisen Niels Ørtenblad Kasper D. Gejl Rasmus Jensen Andreas M. Fritzen Emil L. Larsen Kristian Karstoft Henrik E. Poulsen Thomas Morville Ronni E. Sahl Jørn W. Helge Jens Lund Sarah Falk Mark Lyngbæk Helga Ellingsgaard Bente K. Pedersen Wei Lu Brian Finan Sebastian B. Jørgensen Randy J. Seeley Maximilian Kleinert Bente Kiens Erik A. Richter Christoffer Clemmensen |
| author_sort |
Anders B. Klein |
| title |
Pharmacological but not physiological GDF15 suppresses feeding and the motivation to exercise |
| title_short |
Pharmacological but not physiological GDF15 suppresses feeding and the motivation to exercise |
| title_full |
Pharmacological but not physiological GDF15 suppresses feeding and the motivation to exercise |
| title_fullStr |
Pharmacological but not physiological GDF15 suppresses feeding and the motivation to exercise |
| title_full_unstemmed |
Pharmacological but not physiological GDF15 suppresses feeding and the motivation to exercise |
| title_sort |
pharmacological but not physiological gdf15 suppresses feeding and the motivation to exercise |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/8f1d9eea4091471ca84ea46086fb7636 |
| work_keys_str_mv |
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| _version_ |
1718396481906409472 |