Tsc1-mTORC1 signaling controls striatal dopamine release and cognitive flexibility

Tuberous Sclerosis Complex (TSC) is a neurodevelopmental disorder caused by mutations in the TSC1 or TSC2 genes, which negatively regulate mTORC1 signalling. Here the authors selectively delete Tsc1 from dopamine neurons in mice and find impairments in striatal dopamine release that are sufficient t...

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Autores principales:	Polina Kosillo, Natalie M. Doig, Kamran M. Ahmed, Alexander H.C.W. Agopyan-Miu, Corinna D. Wong, Lisa Conyers, Sarah Threlfell, Peter J. Magill, Helen S. Bateup
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8f206497b65e4d93a92d89d476e37c28
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spelling	oai:doaj.org-article:8f206497b65e4d93a92d89d476e37c282021-12-02T15:35:39ZTsc1-mTORC1 signaling controls striatal dopamine release and cognitive flexibility10.1038/s41467-019-13396-82041-1723https://doaj.org/article/8f206497b65e4d93a92d89d476e37c282019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13396-8https://doaj.org/toc/2041-1723Tuberous Sclerosis Complex (TSC) is a neurodevelopmental disorder caused by mutations in the TSC1 or TSC2 genes, which negatively regulate mTORC1 signalling. Here the authors selectively delete Tsc1 from dopamine neurons in mice and find impairments in striatal dopamine release that are sufficient to reduce cognitive flexibility.Polina KosilloNatalie M. DoigKamran M. AhmedAlexander H.C.W. Agopyan-MiuCorinna D. WongLisa ConyersSarah ThrelfellPeter J. MagillHelen S. BateupNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Polina Kosillo Natalie M. Doig Kamran M. Ahmed Alexander H.C.W. Agopyan-Miu Corinna D. Wong Lisa Conyers Sarah Threlfell Peter J. Magill Helen S. Bateup Tsc1-mTORC1 signaling controls striatal dopamine release and cognitive flexibility
description	Tuberous Sclerosis Complex (TSC) is a neurodevelopmental disorder caused by mutations in the TSC1 or TSC2 genes, which negatively regulate mTORC1 signalling. Here the authors selectively delete Tsc1 from dopamine neurons in mice and find impairments in striatal dopamine release that are sufficient to reduce cognitive flexibility.
format	article
author	Polina Kosillo Natalie M. Doig Kamran M. Ahmed Alexander H.C.W. Agopyan-Miu Corinna D. Wong Lisa Conyers Sarah Threlfell Peter J. Magill Helen S. Bateup
author_facet	Polina Kosillo Natalie M. Doig Kamran M. Ahmed Alexander H.C.W. Agopyan-Miu Corinna D. Wong Lisa Conyers Sarah Threlfell Peter J. Magill Helen S. Bateup
author_sort	Polina Kosillo
title	Tsc1-mTORC1 signaling controls striatal dopamine release and cognitive flexibility
title_short	Tsc1-mTORC1 signaling controls striatal dopamine release and cognitive flexibility
title_full	Tsc1-mTORC1 signaling controls striatal dopamine release and cognitive flexibility
title_fullStr	Tsc1-mTORC1 signaling controls striatal dopamine release and cognitive flexibility
title_full_unstemmed	Tsc1-mTORC1 signaling controls striatal dopamine release and cognitive flexibility
title_sort	tsc1-mtorc1 signaling controls striatal dopamine release and cognitive flexibility
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/8f206497b65e4d93a92d89d476e37c28
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Tsc1-mTORC1 signaling controls striatal dopamine release and cognitive flexibility

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