A Nomogram Model for Predicting the Response to Transcatheter Arterial Embolization in Patients With Symptomatic Hepatic Hemangioma
Background: Transcatheter arterial embolization (TAE) is regarded as an effective treatment for patients with symptomatic hepatic hemangioma. However, few studies have evaluated the efficacy of TAE alone for treating hepatic hemangioma. The aim of this study was to identify the factors that influenc...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:8f25c9f3aa6e49519f3b184a29dc4ddc2021-12-01T05:58:59ZA Nomogram Model for Predicting the Response to Transcatheter Arterial Embolization in Patients With Symptomatic Hepatic Hemangioma2296-889X10.3389/fmolb.2021.722864https://doaj.org/article/8f25c9f3aa6e49519f3b184a29dc4ddc2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmolb.2021.722864/fullhttps://doaj.org/toc/2296-889XBackground: Transcatheter arterial embolization (TAE) is regarded as an effective treatment for patients with symptomatic hepatic hemangioma. However, few studies have evaluated the efficacy of TAE alone for treating hepatic hemangioma. The aim of this study was to identify the factors that influence the response to TAE and formulate a quantitative nomogram to optimize the individualized management of hepatic hemangioma.Methods: We retrospectively studied 276 patients treated with TAE for hepatic hemangioma at our center from January 2011 to December 2019. The full cohort was randomly divided into training and validation cohorts. After assessing the potential predictive factors for the efficacy of TAE in the training cohort, a nomogram model was established and evaluated by discrimination and calibration.Results: During follow-up, the symptom relief rate was 100%. The tumor blood supply (p < 0.001), tumor number (p = 0.004), and tumor size (p = 0.006) were identified as significant predictors of the failure of tumor shrinkage in response to TAE. The nomogram model showed favorable discrimination and calibration, with a C-index of 0.775 (95% CI, 0.705–0.845) in the training cohort, which was further confirmed in the validation cohort (C-index 0.768; 95% CI, 0.680–0.856). The side effects of TAE were relatively minor and included mainly abdominal pain, nausea, vomiting, fever, and the presence of elevated hepatic transaminases.Conclusion: TAE is a safe and effective treatment for symptomatic hepatic hemangioma. The established nomogram performed well for the estimation of the effect of TAE in patients with hepatic hemangioma and can facilitate the selection of patients who would benefit most from the treatment.Qinqin LiuQinqin LiuNan YouJiangqin ZhuJing LiKe WuZheng WangLiang WangYinan ZhuHuiying GuXuehui PengLu ZhengFrontiers Media S.A.articlenomogramtherapeutic responsetranscatheter arterial embolizationsymptomatic hepatic hemangiomaefficacyBiology (General)QH301-705.5ENFrontiers in Molecular Biosciences, Vol 8 (2021) |
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nomogram therapeutic response transcatheter arterial embolization symptomatic hepatic hemangioma efficacy Biology (General) QH301-705.5 |
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nomogram therapeutic response transcatheter arterial embolization symptomatic hepatic hemangioma efficacy Biology (General) QH301-705.5 Qinqin Liu Qinqin Liu Nan You Jiangqin Zhu Jing Li Ke Wu Zheng Wang Liang Wang Yinan Zhu Huiying Gu Xuehui Peng Lu Zheng A Nomogram Model for Predicting the Response to Transcatheter Arterial Embolization in Patients With Symptomatic Hepatic Hemangioma |
| description |
Background: Transcatheter arterial embolization (TAE) is regarded as an effective treatment for patients with symptomatic hepatic hemangioma. However, few studies have evaluated the efficacy of TAE alone for treating hepatic hemangioma. The aim of this study was to identify the factors that influence the response to TAE and formulate a quantitative nomogram to optimize the individualized management of hepatic hemangioma.Methods: We retrospectively studied 276 patients treated with TAE for hepatic hemangioma at our center from January 2011 to December 2019. The full cohort was randomly divided into training and validation cohorts. After assessing the potential predictive factors for the efficacy of TAE in the training cohort, a nomogram model was established and evaluated by discrimination and calibration.Results: During follow-up, the symptom relief rate was 100%. The tumor blood supply (p < 0.001), tumor number (p = 0.004), and tumor size (p = 0.006) were identified as significant predictors of the failure of tumor shrinkage in response to TAE. The nomogram model showed favorable discrimination and calibration, with a C-index of 0.775 (95% CI, 0.705–0.845) in the training cohort, which was further confirmed in the validation cohort (C-index 0.768; 95% CI, 0.680–0.856). The side effects of TAE were relatively minor and included mainly abdominal pain, nausea, vomiting, fever, and the presence of elevated hepatic transaminases.Conclusion: TAE is a safe and effective treatment for symptomatic hepatic hemangioma. The established nomogram performed well for the estimation of the effect of TAE in patients with hepatic hemangioma and can facilitate the selection of patients who would benefit most from the treatment. |
| format |
article |
| author |
Qinqin Liu Qinqin Liu Nan You Jiangqin Zhu Jing Li Ke Wu Zheng Wang Liang Wang Yinan Zhu Huiying Gu Xuehui Peng Lu Zheng |
| author_facet |
Qinqin Liu Qinqin Liu Nan You Jiangqin Zhu Jing Li Ke Wu Zheng Wang Liang Wang Yinan Zhu Huiying Gu Xuehui Peng Lu Zheng |
| author_sort |
Qinqin Liu |
| title |
A Nomogram Model for Predicting the Response to Transcatheter Arterial Embolization in Patients With Symptomatic Hepatic Hemangioma |
| title_short |
A Nomogram Model for Predicting the Response to Transcatheter Arterial Embolization in Patients With Symptomatic Hepatic Hemangioma |
| title_full |
A Nomogram Model for Predicting the Response to Transcatheter Arterial Embolization in Patients With Symptomatic Hepatic Hemangioma |
| title_fullStr |
A Nomogram Model for Predicting the Response to Transcatheter Arterial Embolization in Patients With Symptomatic Hepatic Hemangioma |
| title_full_unstemmed |
A Nomogram Model for Predicting the Response to Transcatheter Arterial Embolization in Patients With Symptomatic Hepatic Hemangioma |
| title_sort |
nomogram model for predicting the response to transcatheter arterial embolization in patients with symptomatic hepatic hemangioma |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/8f25c9f3aa6e49519f3b184a29dc4ddc |
| work_keys_str_mv |
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