HOUSE DUST MITE ALLERGY IN VIEW OF MOLECULAR ALLERGOLOGY

Abstract. Incidence of allergic diseases is increased over last years. House dust is considered a major risk factor of allergic sensitization which plays an important role in development of allergic rhinitis, bronchial asthma, atopic dermatitis. Dust mites in the home comprise a large part of domest...

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Autores principales:	E. S. Korovkina, M. A. Mokronosova
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	house dust mites der p 1 der p 2 tropomyosin component-resolved immune diagnostics allergen-specific immunotherapy Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/8f26857950bd4eb69e6ea89e19e89a2d
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spelling	oai:doaj.org-article:8f26857950bd4eb69e6ea89e19e89a2d2021-11-18T08:03:40ZHOUSE DUST MITE ALLERGY IN VIEW OF MOLECULAR ALLERGOLOGY1563-06252313-741X10.15789/1563-0625-2012-4-5-279-288https://doaj.org/article/8f26857950bd4eb69e6ea89e19e89a2d2014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/416https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. Incidence of allergic diseases is increased over last years. House dust is considered a major risk factor of allergic sensitization which plays an important role in development of allergic rhinitis, bronchial asthma, atopic dermatitis. Dust mites in the home comprise a large part of domestic allergens. Dermatophagoides pteronyssinus, Dermatophagoides farinae, Euroglyphus maynei, Lepidoglyphus destructor, Blomia tropicalis are most important in this respect. Der p 1 and Der p 2 are regarded as major house dust mite allergens. Recent studies concerned induction of IgE responses against mite tropomyosin (Der p 10), an allergen occurring in mites which exhibits high cross-reactivity with tropomyosins from a variety of sea foods (e.g. shrimps), as well as human tropomyosins. Allergen-specific immunotherapy (ASIT) represents the only causative approach to allergy treatment in such cases. From this viewpoint, a quantitation of specific IgЕ against major house dust mite allergens would be necessary to predict ASIT efficiency. Treatment by house dust mites allergen extracts is effective in management of allergic rhinitis and mild asthma. A component-resolved diagnostic (CRD) with purified house-dust mites allergens allows to discriminate patients who were mostly sensitized to the major house dust mites allergens (e.g. Der p 10, tropomyosin). The component-resolved diagnostics could be performed before starting the allergen-specific immunotherapy by mite allergens, in order to avoid unresponsiveness to this mode of therapy.E. S. KorovkinaM. A. MokronosovaSPb RAACIarticlehouse dust mitesder p 1der p 2tropomyosincomponent-resolved immune diagnosticsallergen-specific immunotherapyImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 14, Iss 4-5, Pp 279-288 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	house dust mites der p 1 der p 2 tropomyosin component-resolved immune diagnostics allergen-specific immunotherapy Immunologic diseases. Allergy RC581-607
spellingShingle	house dust mites der p 1 der p 2 tropomyosin component-resolved immune diagnostics allergen-specific immunotherapy Immunologic diseases. Allergy RC581-607 E. S. Korovkina M. A. Mokronosova HOUSE DUST MITE ALLERGY IN VIEW OF MOLECULAR ALLERGOLOGY
description	Abstract. Incidence of allergic diseases is increased over last years. House dust is considered a major risk factor of allergic sensitization which plays an important role in development of allergic rhinitis, bronchial asthma, atopic dermatitis. Dust mites in the home comprise a large part of domestic allergens. Dermatophagoides pteronyssinus, Dermatophagoides farinae, Euroglyphus maynei, Lepidoglyphus destructor, Blomia tropicalis are most important in this respect. Der p 1 and Der p 2 are regarded as major house dust mite allergens. Recent studies concerned induction of IgE responses against mite tropomyosin (Der p 10), an allergen occurring in mites which exhibits high cross-reactivity with tropomyosins from a variety of sea foods (e.g. shrimps), as well as human tropomyosins. Allergen-specific immunotherapy (ASIT) represents the only causative approach to allergy treatment in such cases. From this viewpoint, a quantitation of specific IgЕ against major house dust mite allergens would be necessary to predict ASIT efficiency. Treatment by house dust mites allergen extracts is effective in management of allergic rhinitis and mild asthma. A component-resolved diagnostic (CRD) with purified house-dust mites allergens allows to discriminate patients who were mostly sensitized to the major house dust mites allergens (e.g. Der p 10, tropomyosin). The component-resolved diagnostics could be performed before starting the allergen-specific immunotherapy by mite allergens, in order to avoid unresponsiveness to this mode of therapy.
format	article
author	E. S. Korovkina M. A. Mokronosova
author_facet	E. S. Korovkina M. A. Mokronosova
author_sort	E. S. Korovkina
title	HOUSE DUST MITE ALLERGY IN VIEW OF MOLECULAR ALLERGOLOGY
title_short	HOUSE DUST MITE ALLERGY IN VIEW OF MOLECULAR ALLERGOLOGY
title_full	HOUSE DUST MITE ALLERGY IN VIEW OF MOLECULAR ALLERGOLOGY
title_fullStr	HOUSE DUST MITE ALLERGY IN VIEW OF MOLECULAR ALLERGOLOGY
title_full_unstemmed	HOUSE DUST MITE ALLERGY IN VIEW OF MOLECULAR ALLERGOLOGY
title_sort	house dust mite allergy in view of molecular allergology
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/8f26857950bd4eb69e6ea89e19e89a2d
work_keys_str_mv	AT eskorovkina housedustmiteallergyinviewofmolecularallergology AT mamokronosova housedustmiteallergyinviewofmolecularallergology
_version_	1718422491847720960

HOUSE DUST MITE ALLERGY IN VIEW OF MOLECULAR ALLERGOLOGY

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