Drug treatment of type 2 diabetes mellitus in patients for whom metformin is contraindicated

Brian K Irons,1 Molly G Minze21Department of Pharmacy Practice, Texas Tech University Health Sciences Center School of Pharmacy, Lubbock, 2Department of Pharmacy Practice, Texas Tech University Health Sciences Center School of Pharmacy, Abilene, TX, USAAbstract: Metformin is considered an initial d...

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Autores principales:	Irons BK, Minze MG
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/8f281d684b0a4780a93f1e53447d1798
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spelling	oai:doaj.org-article:8f281d684b0a4780a93f1e53447d17982021-12-02T00:40:55ZDrug treatment of type 2 diabetes mellitus in patients for whom metformin is contraindicated1178-7007https://doaj.org/article/8f281d684b0a4780a93f1e53447d17982014-01-01T00:00:00Zhttp://www.dovepress.com/drug-treatment-of-type-2-diabetes-mellitus-in-patients-for-whom-metfor-a15547https://doaj.org/toc/1178-7007 Brian K Irons,1 Molly G Minze21Department of Pharmacy Practice, Texas Tech University Health Sciences Center School of Pharmacy, Lubbock, 2Department of Pharmacy Practice, Texas Tech University Health Sciences Center School of Pharmacy, Abilene, TX, USAAbstract: Metformin is considered an initial drug of choice for type 2 diabetes mellitus by leading recommendations. When contraindications to its use exist or patients cannot tolerate it due to adverse effects, clinicians have a variety of other classes of agents to treat hyperglycemia associated with type 2 diabetes mellitus. Each class of agent has its own benefit and safety profile. There are numerous factors to consider when selecting another agent in lieu of metformin including, but not limited to, overall efficacy in A1c reduction, adverse effect profile, cost, and patient preference. The number of factors influencing the decision process presents challenges and often no one specific agent is ideal. Each pharmacotherapeutic class of agents alternative to metformin for the treatment of hyperglycemia in type 2 diabetes mellitus as initial monotherapy is reviewed.Keywords: type 2 diabetes mellitus, metformin, monotherapy, hyperglycemia, pharmacotherapyIrons BKMinze MGDove Medical PressarticleSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol 2014, Iss default, Pp 15-24 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Specialties of internal medicine RC581-951
spellingShingle	Specialties of internal medicine RC581-951 Irons BK Minze MG Drug treatment of type 2 diabetes mellitus in patients for whom metformin is contraindicated
description	Brian K Irons,1 Molly G Minze21Department of Pharmacy Practice, Texas Tech University Health Sciences Center School of Pharmacy, Lubbock, 2Department of Pharmacy Practice, Texas Tech University Health Sciences Center School of Pharmacy, Abilene, TX, USAAbstract: Metformin is considered an initial drug of choice for type 2 diabetes mellitus by leading recommendations. When contraindications to its use exist or patients cannot tolerate it due to adverse effects, clinicians have a variety of other classes of agents to treat hyperglycemia associated with type 2 diabetes mellitus. Each class of agent has its own benefit and safety profile. There are numerous factors to consider when selecting another agent in lieu of metformin including, but not limited to, overall efficacy in A1c reduction, adverse effect profile, cost, and patient preference. The number of factors influencing the decision process presents challenges and often no one specific agent is ideal. Each pharmacotherapeutic class of agents alternative to metformin for the treatment of hyperglycemia in type 2 diabetes mellitus as initial monotherapy is reviewed.Keywords: type 2 diabetes mellitus, metformin, monotherapy, hyperglycemia, pharmacotherapy
format	article
author	Irons BK Minze MG
author_facet	Irons BK Minze MG
author_sort	Irons BK
title	Drug treatment of type 2 diabetes mellitus in patients for whom metformin is contraindicated
title_short	Drug treatment of type 2 diabetes mellitus in patients for whom metformin is contraindicated
title_full	Drug treatment of type 2 diabetes mellitus in patients for whom metformin is contraindicated
title_fullStr	Drug treatment of type 2 diabetes mellitus in patients for whom metformin is contraindicated
title_full_unstemmed	Drug treatment of type 2 diabetes mellitus in patients for whom metformin is contraindicated
title_sort	drug treatment of type 2 diabetes mellitus in patients for whom metformin is contraindicated
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/8f281d684b0a4780a93f1e53447d1798
work_keys_str_mv	AT ironsbk drugtreatmentoftype2diabetesmellitusinpatientsforwhommetforminiscontraindicated AT minzemg drugtreatmentoftype2diabetesmellitusinpatientsforwhommetforminiscontraindicated
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Drug treatment of type 2 diabetes mellitus in patients for whom metformin is contraindicated

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