Fused Deposition Modeling (FDM) 3D Printed Tablets for Intragastric Floating Delivery of Domperidone

Abstract The aim of this study was to explore the feasibility of fused deposition modeling (FDM) 3D printing to prepare intragastric floating sustained release (FSR) tablets. Domperidone (DOM), an insoluble weak base, was chosen as a model drug to investigate the potential of FSR in increasing its o...

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Autores principales:	Xuyu Chai, Hongyu Chai, Xiaoyu Wang, Jingjing Yang, Jin Li, Yan Zhao, Weimin Cai, Tao Tao, Xiaoqiang Xiang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8f2c9fd73d224105875b2061744c0aba
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spelling	oai:doaj.org-article:8f2c9fd73d224105875b2061744c0aba2021-12-02T15:05:22ZFused Deposition Modeling (FDM) 3D Printed Tablets for Intragastric Floating Delivery of Domperidone10.1038/s41598-017-03097-x2045-2322https://doaj.org/article/8f2c9fd73d224105875b2061744c0aba2017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-03097-xhttps://doaj.org/toc/2045-2322Abstract The aim of this study was to explore the feasibility of fused deposition modeling (FDM) 3D printing to prepare intragastric floating sustained release (FSR) tablets. Domperidone (DOM), an insoluble weak base, was chosen as a model drug to investigate the potential of FSR in increasing its oral bioavailability and reducing its administration frequency. DOM was successfully loaded into hydroxypropyl cellulose (HPC) filaments using hot melt extrusion (HME). The filaments were then printed into hollow structured tablets through changing the shell numbers and the infill percentages. Physical characterization results indicated that the majority of DOM gradually turned into the amorphous form during the fabrication process. The optimized formulation (contain 10% DOM, with 2 shells and 0% infill) exhibited the sustained release characteristic and was able to float for about 10 h in vitro. Radiographic images showed that the BaSO4-labeled tablets were retained in the stomach of rabbits for more than 8 h. Furthermore, pharmacokinetic studies showed the relative bioavailability of the FSR tablets compared with reference commercial tablets was 222.49 ± 62.85%. All the results showed that FDM based 3D printing might be a promising way to fabricate hollow tablets for the purpose of intragastric floating drug delivery.Xuyu ChaiHongyu ChaiXiaoyu WangJingjing YangJin LiYan ZhaoWeimin CaiTao TaoXiaoqiang XiangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xuyu Chai Hongyu Chai Xiaoyu Wang Jingjing Yang Jin Li Yan Zhao Weimin Cai Tao Tao Xiaoqiang Xiang Fused Deposition Modeling (FDM) 3D Printed Tablets for Intragastric Floating Delivery of Domperidone
description	Abstract The aim of this study was to explore the feasibility of fused deposition modeling (FDM) 3D printing to prepare intragastric floating sustained release (FSR) tablets. Domperidone (DOM), an insoluble weak base, was chosen as a model drug to investigate the potential of FSR in increasing its oral bioavailability and reducing its administration frequency. DOM was successfully loaded into hydroxypropyl cellulose (HPC) filaments using hot melt extrusion (HME). The filaments were then printed into hollow structured tablets through changing the shell numbers and the infill percentages. Physical characterization results indicated that the majority of DOM gradually turned into the amorphous form during the fabrication process. The optimized formulation (contain 10% DOM, with 2 shells and 0% infill) exhibited the sustained release characteristic and was able to float for about 10 h in vitro. Radiographic images showed that the BaSO4-labeled tablets were retained in the stomach of rabbits for more than 8 h. Furthermore, pharmacokinetic studies showed the relative bioavailability of the FSR tablets compared with reference commercial tablets was 222.49 ± 62.85%. All the results showed that FDM based 3D printing might be a promising way to fabricate hollow tablets for the purpose of intragastric floating drug delivery.
format	article
author	Xuyu Chai Hongyu Chai Xiaoyu Wang Jingjing Yang Jin Li Yan Zhao Weimin Cai Tao Tao Xiaoqiang Xiang
author_facet	Xuyu Chai Hongyu Chai Xiaoyu Wang Jingjing Yang Jin Li Yan Zhao Weimin Cai Tao Tao Xiaoqiang Xiang
author_sort	Xuyu Chai
title	Fused Deposition Modeling (FDM) 3D Printed Tablets for Intragastric Floating Delivery of Domperidone
title_short	Fused Deposition Modeling (FDM) 3D Printed Tablets for Intragastric Floating Delivery of Domperidone
title_full	Fused Deposition Modeling (FDM) 3D Printed Tablets for Intragastric Floating Delivery of Domperidone
title_fullStr	Fused Deposition Modeling (FDM) 3D Printed Tablets for Intragastric Floating Delivery of Domperidone
title_full_unstemmed	Fused Deposition Modeling (FDM) 3D Printed Tablets for Intragastric Floating Delivery of Domperidone
title_sort	fused deposition modeling (fdm) 3d printed tablets for intragastric floating delivery of domperidone
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/8f2c9fd73d224105875b2061744c0aba
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Fused Deposition Modeling (FDM) 3D Printed Tablets for Intragastric Floating Delivery of Domperidone

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