Enrichment analyses of diseases and pathways associated with precocious puberty using PrecocityDB
Abstract Precocious puberty (PP) is an important endocrine disorder affecting children globally. Several genes, SNPs and comorbidities are reported to be associated with PP; however, this data is scattered across scientific literature and has not been systematically collated and analysed. In this st...
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Nature Portfolio
2021
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oai:doaj.org-article:8f31a4fa834048ce99adae6a23b646b12021-12-02T14:03:59ZEnrichment analyses of diseases and pathways associated with precocious puberty using PrecocityDB10.1038/s41598-021-83446-z2045-2322https://doaj.org/article/8f31a4fa834048ce99adae6a23b646b12021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83446-zhttps://doaj.org/toc/2045-2322Abstract Precocious puberty (PP) is an important endocrine disorder affecting children globally. Several genes, SNPs and comorbidities are reported to be associated with PP; however, this data is scattered across scientific literature and has not been systematically collated and analysed. In this study, we present PrecocityDB as the first manually curated online database on genes and their ontology terms, SNPs, and pathways associated with PP. A tool for visualizing SNP coordinates and allelic variation on each chromosome, for genes associated with PP is also incorporated in PrecocityDB. Pathway enrichment analysis of PP-associated genes revealed that endocrine and cancer-related pathways are highly enriched. Disease enrichment analysis indicated that individuals with PP seem to be highly likely to suffer from reproductive and metabolic disorders such as PCOS, hypogonadism, and insulin resistance. PrecocityDB is a useful resource for identification of comorbid conditions and disease risks due to shared genes in PP. PrecocityDB is freely accessible at http://www.precocity.bicnirrh.res.in . The database source code and content can be downloaded through GitHub ( https://github.com/bic-nirrh/precocity ).Mridula SharmaIndra KunduRam Shankar BaraiSameeksha BhayeKarishma DesaiKhushal PokarSusan Idicula-ThomasNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021) |
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Medicine R Science Q |
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Medicine R Science Q Mridula Sharma Indra Kundu Ram Shankar Barai Sameeksha Bhaye Karishma Desai Khushal Pokar Susan Idicula-Thomas Enrichment analyses of diseases and pathways associated with precocious puberty using PrecocityDB |
| description |
Abstract Precocious puberty (PP) is an important endocrine disorder affecting children globally. Several genes, SNPs and comorbidities are reported to be associated with PP; however, this data is scattered across scientific literature and has not been systematically collated and analysed. In this study, we present PrecocityDB as the first manually curated online database on genes and their ontology terms, SNPs, and pathways associated with PP. A tool for visualizing SNP coordinates and allelic variation on each chromosome, for genes associated with PP is also incorporated in PrecocityDB. Pathway enrichment analysis of PP-associated genes revealed that endocrine and cancer-related pathways are highly enriched. Disease enrichment analysis indicated that individuals with PP seem to be highly likely to suffer from reproductive and metabolic disorders such as PCOS, hypogonadism, and insulin resistance. PrecocityDB is a useful resource for identification of comorbid conditions and disease risks due to shared genes in PP. PrecocityDB is freely accessible at http://www.precocity.bicnirrh.res.in . The database source code and content can be downloaded through GitHub ( https://github.com/bic-nirrh/precocity ). |
| format |
article |
| author |
Mridula Sharma Indra Kundu Ram Shankar Barai Sameeksha Bhaye Karishma Desai Khushal Pokar Susan Idicula-Thomas |
| author_facet |
Mridula Sharma Indra Kundu Ram Shankar Barai Sameeksha Bhaye Karishma Desai Khushal Pokar Susan Idicula-Thomas |
| author_sort |
Mridula Sharma |
| title |
Enrichment analyses of diseases and pathways associated with precocious puberty using PrecocityDB |
| title_short |
Enrichment analyses of diseases and pathways associated with precocious puberty using PrecocityDB |
| title_full |
Enrichment analyses of diseases and pathways associated with precocious puberty using PrecocityDB |
| title_fullStr |
Enrichment analyses of diseases and pathways associated with precocious puberty using PrecocityDB |
| title_full_unstemmed |
Enrichment analyses of diseases and pathways associated with precocious puberty using PrecocityDB |
| title_sort |
enrichment analyses of diseases and pathways associated with precocious puberty using precocitydb |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/8f31a4fa834048ce99adae6a23b646b1 |
| work_keys_str_mv |
AT mridulasharma enrichmentanalysesofdiseasesandpathwaysassociatedwithprecociouspubertyusingprecocitydb AT indrakundu enrichmentanalysesofdiseasesandpathwaysassociatedwithprecociouspubertyusingprecocitydb AT ramshankarbarai enrichmentanalysesofdiseasesandpathwaysassociatedwithprecociouspubertyusingprecocitydb AT sameekshabhaye enrichmentanalysesofdiseasesandpathwaysassociatedwithprecociouspubertyusingprecocitydb AT karishmadesai enrichmentanalysesofdiseasesandpathwaysassociatedwithprecociouspubertyusingprecocitydb AT khushalpokar enrichmentanalysesofdiseasesandpathwaysassociatedwithprecociouspubertyusingprecocitydb AT susanidiculathomas enrichmentanalysesofdiseasesandpathwaysassociatedwithprecociouspubertyusingprecocitydb |
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