The oncogenic role of microRNA-130a/301a/454 in human colorectal cancer via targeting Smad4 expression.

Transforming growth factor (TGF)-β/Smad signaling plays an important role in colon cancer development, progression and metastasis. In this study we demonstrated that the microRNA-130a/301a/454 family is up-regulated in colon cancer tissues compared to paired adjacent normal mucosa, which share the s...

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Autores principales:	Lin Liu, Jing Nie, Lin Chen, Guanglong Dong, Xiaohui Du, Xin Wu, Yun Tang, Weidong Han
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8f35e1305468435aa1fcd60c90cc108c
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spelling	oai:doaj.org-article:8f35e1305468435aa1fcd60c90cc108c2021-11-18T07:58:47ZThe oncogenic role of microRNA-130a/301a/454 in human colorectal cancer via targeting Smad4 expression.1932-620310.1371/journal.pone.0055532https://doaj.org/article/8f35e1305468435aa1fcd60c90cc108c2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23393589/?tool=EBIhttps://doaj.org/toc/1932-6203Transforming growth factor (TGF)-β/Smad signaling plays an important role in colon cancer development, progression and metastasis. In this study we demonstrated that the microRNA-130a/301a/454 family is up-regulated in colon cancer tissues compared to paired adjacent normal mucosa, which share the same 3'-untranslational region (3'-UTR) binding seed sequence and are predicated to target Smad4. In colorectal cancer HCT116 and SW480 cells, overexpression of miRNA-130a/301a/454 mimics enhances cell proliferation and migration, while inhibitors of these miRNAs affect cell survival. The biological function of miRNA-130a/301a/454 on colon cancer cells is likely mediated by suppression of Smad4, and the up-regulation of the miRNAs is correlated with Smad4 down-regulation in human colon cancers. Collectively, these results suggest that miRNA-130a/301a/454 are novel oncogenic miRNAs contributing to colon tumorigenesis by regulating TGF-β/Smad signaling, which may have potential application in cancer therapy.Lin LiuJing NieLin ChenGuanglong DongXiaohui DuXin WuYun TangWeidong HanPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 2, p e55532 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lin Liu Jing Nie Lin Chen Guanglong Dong Xiaohui Du Xin Wu Yun Tang Weidong Han The oncogenic role of microRNA-130a/301a/454 in human colorectal cancer via targeting Smad4 expression.
description	Transforming growth factor (TGF)-β/Smad signaling plays an important role in colon cancer development, progression and metastasis. In this study we demonstrated that the microRNA-130a/301a/454 family is up-regulated in colon cancer tissues compared to paired adjacent normal mucosa, which share the same 3'-untranslational region (3'-UTR) binding seed sequence and are predicated to target Smad4. In colorectal cancer HCT116 and SW480 cells, overexpression of miRNA-130a/301a/454 mimics enhances cell proliferation and migration, while inhibitors of these miRNAs affect cell survival. The biological function of miRNA-130a/301a/454 on colon cancer cells is likely mediated by suppression of Smad4, and the up-regulation of the miRNAs is correlated with Smad4 down-regulation in human colon cancers. Collectively, these results suggest that miRNA-130a/301a/454 are novel oncogenic miRNAs contributing to colon tumorigenesis by regulating TGF-β/Smad signaling, which may have potential application in cancer therapy.
format	article
author	Lin Liu Jing Nie Lin Chen Guanglong Dong Xiaohui Du Xin Wu Yun Tang Weidong Han
author_facet	Lin Liu Jing Nie Lin Chen Guanglong Dong Xiaohui Du Xin Wu Yun Tang Weidong Han
author_sort	Lin Liu
title	The oncogenic role of microRNA-130a/301a/454 in human colorectal cancer via targeting Smad4 expression.
title_short	The oncogenic role of microRNA-130a/301a/454 in human colorectal cancer via targeting Smad4 expression.
title_full	The oncogenic role of microRNA-130a/301a/454 in human colorectal cancer via targeting Smad4 expression.
title_fullStr	The oncogenic role of microRNA-130a/301a/454 in human colorectal cancer via targeting Smad4 expression.
title_full_unstemmed	The oncogenic role of microRNA-130a/301a/454 in human colorectal cancer via targeting Smad4 expression.
title_sort	oncogenic role of microrna-130a/301a/454 in human colorectal cancer via targeting smad4 expression.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/8f35e1305468435aa1fcd60c90cc108c
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The oncogenic role of microRNA-130a/301a/454 in human colorectal cancer via targeting Smad4 expression.

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