Pharmaceutical Applications of Supercritical Fluid Extraction of Emulsions for Micro-/Nanoparticle Formation

Micro-/nanoparticle formulations containing drugs with or without various biocompatible excipients are widely used in the pharmaceutical field to improve the physicochemical and clinical properties of the final drug product. Among the various micro-/nanoparticle production technologies, emulsion-bas...

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Autores principales:	Heejun Park, Jeong-Soo Kim, Sebin Kim, Eun-Sol Ha, Min-Soo Kim, Sung-Joo Hwang
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	supercritical fluid supercritical fluid extraction of emulsions micro-/nanoparticle pharmaceutical application Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/8f3a70825ebb4594b07a8b25f1dc92ca
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spelling	oai:doaj.org-article:8f3a70825ebb4594b07a8b25f1dc92ca2021-11-25T18:41:58ZPharmaceutical Applications of Supercritical Fluid Extraction of Emulsions for Micro-/Nanoparticle Formation10.3390/pharmaceutics131119281999-4923https://doaj.org/article/8f3a70825ebb4594b07a8b25f1dc92ca2021-11-01T00:00:00Zhttps://www.mdpi.com/1999-4923/13/11/1928https://doaj.org/toc/1999-4923Micro-/nanoparticle formulations containing drugs with or without various biocompatible excipients are widely used in the pharmaceutical field to improve the physicochemical and clinical properties of the final drug product. Among the various micro-/nanoparticle production technologies, emulsion-based particle formation is the most widely used because of its unique advantages such as uniform generation of spherical small particles and higher encapsulation efficiency (EE). For this emulsion-based micro-/nanoparticle technology, one of the most important factors is the extraction efficiency associated with the fast removal of the organic solvent. In consideration of this, a technology called supercritical fluid extraction of emulsions (SFEE) that uses the unique mass transfer mechanism and solvent power of a supercritical fluid (SCF) has been proposed to overcome the shortcomings of several conventional technologies such as solvent evaporation, extraction, and spray drying. This review article presents the main aspects of SFEE technology for the preparation of micro-/nanoparticles by focusing on its pharmaceutical applications, which have been organized and classified according to several types of drug delivery systems and active pharmaceutical ingredients. It was definitely confirmed that SFEE can be applied in a variety of drugs from water-soluble to poorly water-soluble. In addition, it has advantages such as low organic solvent residual, high EE, desirable release control, better particle size control, and agglomeration prevention through efficient and fast solvent removal compared to conventional micro-/nanoparticle technologies. Therefore, this review will be a good resource for determining the applicability of SFEE to obtain better pharmaceutical quality when researchers in related fields want to select a suitable manufacturing process for preparing desired micro-/nanoparticle drug delivery systems containing their active material.Heejun ParkJeong-Soo KimSebin KimEun-Sol HaMin-Soo KimSung-Joo HwangMDPI AGarticlesupercritical fluidsupercritical fluid extraction of emulsionsmicro-/nanoparticlepharmaceutical applicationPharmacy and materia medicaRS1-441ENPharmaceutics, Vol 13, Iss 1928, p 1928 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	supercritical fluid supercritical fluid extraction of emulsions micro-/nanoparticle pharmaceutical application Pharmacy and materia medica RS1-441
spellingShingle	supercritical fluid supercritical fluid extraction of emulsions micro-/nanoparticle pharmaceutical application Pharmacy and materia medica RS1-441 Heejun Park Jeong-Soo Kim Sebin Kim Eun-Sol Ha Min-Soo Kim Sung-Joo Hwang Pharmaceutical Applications of Supercritical Fluid Extraction of Emulsions for Micro-/Nanoparticle Formation
description	Micro-/nanoparticle formulations containing drugs with or without various biocompatible excipients are widely used in the pharmaceutical field to improve the physicochemical and clinical properties of the final drug product. Among the various micro-/nanoparticle production technologies, emulsion-based particle formation is the most widely used because of its unique advantages such as uniform generation of spherical small particles and higher encapsulation efficiency (EE). For this emulsion-based micro-/nanoparticle technology, one of the most important factors is the extraction efficiency associated with the fast removal of the organic solvent. In consideration of this, a technology called supercritical fluid extraction of emulsions (SFEE) that uses the unique mass transfer mechanism and solvent power of a supercritical fluid (SCF) has been proposed to overcome the shortcomings of several conventional technologies such as solvent evaporation, extraction, and spray drying. This review article presents the main aspects of SFEE technology for the preparation of micro-/nanoparticles by focusing on its pharmaceutical applications, which have been organized and classified according to several types of drug delivery systems and active pharmaceutical ingredients. It was definitely confirmed that SFEE can be applied in a variety of drugs from water-soluble to poorly water-soluble. In addition, it has advantages such as low organic solvent residual, high EE, desirable release control, better particle size control, and agglomeration prevention through efficient and fast solvent removal compared to conventional micro-/nanoparticle technologies. Therefore, this review will be a good resource for determining the applicability of SFEE to obtain better pharmaceutical quality when researchers in related fields want to select a suitable manufacturing process for preparing desired micro-/nanoparticle drug delivery systems containing their active material.
format	article
author	Heejun Park Jeong-Soo Kim Sebin Kim Eun-Sol Ha Min-Soo Kim Sung-Joo Hwang
author_facet	Heejun Park Jeong-Soo Kim Sebin Kim Eun-Sol Ha Min-Soo Kim Sung-Joo Hwang
author_sort	Heejun Park
title	Pharmaceutical Applications of Supercritical Fluid Extraction of Emulsions for Micro-/Nanoparticle Formation
title_short	Pharmaceutical Applications of Supercritical Fluid Extraction of Emulsions for Micro-/Nanoparticle Formation
title_full	Pharmaceutical Applications of Supercritical Fluid Extraction of Emulsions for Micro-/Nanoparticle Formation
title_fullStr	Pharmaceutical Applications of Supercritical Fluid Extraction of Emulsions for Micro-/Nanoparticle Formation
title_full_unstemmed	Pharmaceutical Applications of Supercritical Fluid Extraction of Emulsions for Micro-/Nanoparticle Formation
title_sort	pharmaceutical applications of supercritical fluid extraction of emulsions for micro-/nanoparticle formation
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/8f3a70825ebb4594b07a8b25f1dc92ca
work_keys_str_mv	AT heejunpark pharmaceuticalapplicationsofsupercriticalfluidextractionofemulsionsformicronanoparticleformation AT jeongsookim pharmaceuticalapplicationsofsupercriticalfluidextractionofemulsionsformicronanoparticleformation AT sebinkim pharmaceuticalapplicationsofsupercriticalfluidextractionofemulsionsformicronanoparticleformation AT eunsolha pharmaceuticalapplicationsofsupercriticalfluidextractionofemulsionsformicronanoparticleformation AT minsookim pharmaceuticalapplicationsofsupercriticalfluidextractionofemulsionsformicronanoparticleformation AT sungjoohwang pharmaceuticalapplicationsofsupercriticalfluidextractionofemulsionsformicronanoparticleformation
_version_	1718410786873802752

Pharmaceutical Applications of Supercritical Fluid Extraction of Emulsions for Micro-/Nanoparticle Formation

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