The influence of high-efficiency particulate air filtration on mortality among multiple myeloma patients receiving autologous stem cell transplantation

Abstract Autologous stem cell transplantation (ASCT) continues to be the standard treatment for transplant-eligible multiple myeloma (MM) patients. A portion of MM patients received ASCT in an isolation room with high-efficiency particulate air (HEPA) filtration. The effectiveness of the HEPA filtra...

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Autores principales:	Chun-Kuang Tsai, Chiu-Mei Yeh, Ying-Chung Hong, Po-Min Chen, Jin-Hwang Liu, Jyh-Pyng Gau, Chia-Jen Liu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8f3e0856a16d436b86b10491199594b4
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spelling	oai:doaj.org-article:8f3e0856a16d436b86b10491199594b42021-12-02T15:57:03ZThe influence of high-efficiency particulate air filtration on mortality among multiple myeloma patients receiving autologous stem cell transplantation10.1038/s41598-021-91135-02045-2322https://doaj.org/article/8f3e0856a16d436b86b10491199594b42021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91135-0https://doaj.org/toc/2045-2322Abstract Autologous stem cell transplantation (ASCT) continues to be the standard treatment for transplant-eligible multiple myeloma (MM) patients. A portion of MM patients received ASCT in an isolation room with high-efficiency particulate air (HEPA) filtration. The effectiveness of the HEPA filtration on reducing treatment-related mortality (TRM) is controversial. We enrolled patients with newly diagnosed MM in Taiwan between 2000 and 2017. The primary endpoint of the study was TRM, which was defined as death within 100 days after ASCT. A total of 961 MM patients received ASCT. Of them, 480 patients (49.9%) received ASCT in an isolation room with HEPA filtration (HEPA group). The median overall survival from ASCT was 7.52 years for the HEPA group and 5.88 years for the remaining patients (non-HEPA group) (p = 0.370). The 100-day mortality rate was 1.5% and 1.0% for the HEPA and non-HEPA groups, respectively. In the multivariate analysis, the 100-day mortality had no difference between the HEPA and non-HEPA groups (adjusted hazard ratio 1.65, 95% CI 0.52–5.23). The median cost for ASCT inpatient care was $13,777.6 and $6527.6 for the HEPA and non-HEPA groups, respectively (p < 0.001). Although half of MM patients in Taiwan received ASCT in HEPA room, it didn’t affect 100-day mortality.Chun-Kuang TsaiChiu-Mei YehYing-Chung HongPo-Min ChenJin-Hwang LiuJyh-Pyng GauChia-Jen LiuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Chun-Kuang Tsai Chiu-Mei Yeh Ying-Chung Hong Po-Min Chen Jin-Hwang Liu Jyh-Pyng Gau Chia-Jen Liu The influence of high-efficiency particulate air filtration on mortality among multiple myeloma patients receiving autologous stem cell transplantation
description	Abstract Autologous stem cell transplantation (ASCT) continues to be the standard treatment for transplant-eligible multiple myeloma (MM) patients. A portion of MM patients received ASCT in an isolation room with high-efficiency particulate air (HEPA) filtration. The effectiveness of the HEPA filtration on reducing treatment-related mortality (TRM) is controversial. We enrolled patients with newly diagnosed MM in Taiwan between 2000 and 2017. The primary endpoint of the study was TRM, which was defined as death within 100 days after ASCT. A total of 961 MM patients received ASCT. Of them, 480 patients (49.9%) received ASCT in an isolation room with HEPA filtration (HEPA group). The median overall survival from ASCT was 7.52 years for the HEPA group and 5.88 years for the remaining patients (non-HEPA group) (p = 0.370). The 100-day mortality rate was 1.5% and 1.0% for the HEPA and non-HEPA groups, respectively. In the multivariate analysis, the 100-day mortality had no difference between the HEPA and non-HEPA groups (adjusted hazard ratio 1.65, 95% CI 0.52–5.23). The median cost for ASCT inpatient care was $13,777.6 and $6527.6 for the HEPA and non-HEPA groups, respectively (p < 0.001). Although half of MM patients in Taiwan received ASCT in HEPA room, it didn’t affect 100-day mortality.
format	article
author	Chun-Kuang Tsai Chiu-Mei Yeh Ying-Chung Hong Po-Min Chen Jin-Hwang Liu Jyh-Pyng Gau Chia-Jen Liu
author_facet	Chun-Kuang Tsai Chiu-Mei Yeh Ying-Chung Hong Po-Min Chen Jin-Hwang Liu Jyh-Pyng Gau Chia-Jen Liu
author_sort	Chun-Kuang Tsai
title	The influence of high-efficiency particulate air filtration on mortality among multiple myeloma patients receiving autologous stem cell transplantation
title_short	The influence of high-efficiency particulate air filtration on mortality among multiple myeloma patients receiving autologous stem cell transplantation
title_full	The influence of high-efficiency particulate air filtration on mortality among multiple myeloma patients receiving autologous stem cell transplantation
title_fullStr	The influence of high-efficiency particulate air filtration on mortality among multiple myeloma patients receiving autologous stem cell transplantation
title_full_unstemmed	The influence of high-efficiency particulate air filtration on mortality among multiple myeloma patients receiving autologous stem cell transplantation
title_sort	influence of high-efficiency particulate air filtration on mortality among multiple myeloma patients receiving autologous stem cell transplantation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8f3e0856a16d436b86b10491199594b4
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The influence of high-efficiency particulate air filtration on mortality among multiple myeloma patients receiving autologous stem cell transplantation

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