Increased gastric IL-1β concentration and iron deficiency parameters in H. pylori infected children.
Association between H. pylori infection, iron deficiency and iron deficiency anaemia has been described, but the mechanisms involved have not been established. We hypothesized that in H. pylori infected children increased gastric concentrations of IL-1β and/or TNF-α, both potent inhibitors of gastri...
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2013
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oai:doaj.org-article:8f406ed7a02c4b63b6b616e461836e912021-11-18T07:56:05ZIncreased gastric IL-1β concentration and iron deficiency parameters in H. pylori infected children.1932-620310.1371/journal.pone.0057420https://doaj.org/article/8f406ed7a02c4b63b6b616e461836e912013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23451225/?tool=EBIhttps://doaj.org/toc/1932-6203Association between H. pylori infection, iron deficiency and iron deficiency anaemia has been described, but the mechanisms involved have not been established. We hypothesized that in H. pylori infected children increased gastric concentrations of IL-1β and/or TNF-α, both potent inhibitors of gastric acid secretion that is essential for iron absorption, are predictors for low blood concentrations of ferritin and haemoglobin, markers of early depletion of iron stores and anaemia, respectively. We evaluated 125 children undergoing endoscopy to clarify the origin of gastrointestinal symptoms. Gastric specimens were obtained for H. pylori status and cytokine evaluation and blood samples for determination of iron deficiency/iron deficiency anaemia parameters and IL1 cluster and TNFA polymorphisms that are associated with increased cytokine secretions. Higher IL-1β and TNF-α gastric concentrations were observed in H. pylori-positive (n = 47) than in -negative (n = 78) children. Multiple linear regression models revealed gastric IL-1β, but not TNF-α, as a significant predictor of low ferritin and haemoglobin concentrations; results were reproduced in young children in whom IL1RN polymorphic genotypes associated with higher gastric IL-1β expression and lower blood ferritin and haemoglobin concentrations. In conclusion, high gastric levels of IL-1β can be the link between H. pylori infection and iron deficiency/iron deficiency anaemia in childhood.Dulciene Maria Magalhaes QueirozAndreia Maria Camargos RochaFabricio Freire MeloGifone Aguiar RochaKádima Nayara TeixeiraSimone Diniz CarvalhoPaulo Fernando Souto BittencourtLucia Porto Fonseca CastroJean E CrabtreePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 2, p e57420 (2013) |
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Medicine R Science Q |
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Medicine R Science Q Dulciene Maria Magalhaes Queiroz Andreia Maria Camargos Rocha Fabricio Freire Melo Gifone Aguiar Rocha Kádima Nayara Teixeira Simone Diniz Carvalho Paulo Fernando Souto Bittencourt Lucia Porto Fonseca Castro Jean E Crabtree Increased gastric IL-1β concentration and iron deficiency parameters in H. pylori infected children. |
| description |
Association between H. pylori infection, iron deficiency and iron deficiency anaemia has been described, but the mechanisms involved have not been established. We hypothesized that in H. pylori infected children increased gastric concentrations of IL-1β and/or TNF-α, both potent inhibitors of gastric acid secretion that is essential for iron absorption, are predictors for low blood concentrations of ferritin and haemoglobin, markers of early depletion of iron stores and anaemia, respectively. We evaluated 125 children undergoing endoscopy to clarify the origin of gastrointestinal symptoms. Gastric specimens were obtained for H. pylori status and cytokine evaluation and blood samples for determination of iron deficiency/iron deficiency anaemia parameters and IL1 cluster and TNFA polymorphisms that are associated with increased cytokine secretions. Higher IL-1β and TNF-α gastric concentrations were observed in H. pylori-positive (n = 47) than in -negative (n = 78) children. Multiple linear regression models revealed gastric IL-1β, but not TNF-α, as a significant predictor of low ferritin and haemoglobin concentrations; results were reproduced in young children in whom IL1RN polymorphic genotypes associated with higher gastric IL-1β expression and lower blood ferritin and haemoglobin concentrations. In conclusion, high gastric levels of IL-1β can be the link between H. pylori infection and iron deficiency/iron deficiency anaemia in childhood. |
| format |
article |
| author |
Dulciene Maria Magalhaes Queiroz Andreia Maria Camargos Rocha Fabricio Freire Melo Gifone Aguiar Rocha Kádima Nayara Teixeira Simone Diniz Carvalho Paulo Fernando Souto Bittencourt Lucia Porto Fonseca Castro Jean E Crabtree |
| author_facet |
Dulciene Maria Magalhaes Queiroz Andreia Maria Camargos Rocha Fabricio Freire Melo Gifone Aguiar Rocha Kádima Nayara Teixeira Simone Diniz Carvalho Paulo Fernando Souto Bittencourt Lucia Porto Fonseca Castro Jean E Crabtree |
| author_sort |
Dulciene Maria Magalhaes Queiroz |
| title |
Increased gastric IL-1β concentration and iron deficiency parameters in H. pylori infected children. |
| title_short |
Increased gastric IL-1β concentration and iron deficiency parameters in H. pylori infected children. |
| title_full |
Increased gastric IL-1β concentration and iron deficiency parameters in H. pylori infected children. |
| title_fullStr |
Increased gastric IL-1β concentration and iron deficiency parameters in H. pylori infected children. |
| title_full_unstemmed |
Increased gastric IL-1β concentration and iron deficiency parameters in H. pylori infected children. |
| title_sort |
increased gastric il-1β concentration and iron deficiency parameters in h. pylori infected children. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2013 |
| url |
https://doaj.org/article/8f406ed7a02c4b63b6b616e461836e91 |
| work_keys_str_mv |
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