Endobronchial brachytherapy as definitive treatment for endobronchial metastasis after surgery of non-small cell lung cancer

Abstract Background Endobronchial metastasis is a very rare type of recurrence after lung cancer surgery. Surgical intervention may be difficult to perform due to the postoperative reduction in the activities of daily living (ADL) and the invasiveness associated with redo surgery. In such cases, end...

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Autores principales:	Atsushi Ito, Daisuke Yamaguchi, Shinji Kaneda, Koji Kawaguchi, Akira Shimamoto, Makiko Kubooka, Yoshihito Nomoto, Motoshi Takao
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Endobronchial metastasis Endobronchial brachytherapy Definitive treatment Surgery RD1-811 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/8f46a6e280dd4cdf88aac13a6f2a6faa
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spelling	oai:doaj.org-article:8f46a6e280dd4cdf88aac13a6f2a6faa2021-11-14T12:33:42ZEndobronchial brachytherapy as definitive treatment for endobronchial metastasis after surgery of non-small cell lung cancer10.1186/s12957-021-02434-91477-7819https://doaj.org/article/8f46a6e280dd4cdf88aac13a6f2a6faa2021-11-01T00:00:00Zhttps://doi.org/10.1186/s12957-021-02434-9https://doaj.org/toc/1477-7819Abstract Background Endobronchial metastasis is a very rare type of recurrence after lung cancer surgery. Surgical intervention may be difficult to perform due to the postoperative reduction in the activities of daily living (ADL) and the invasiveness associated with redo surgery. In such cases, endobronchial brachytherapy (EBBT) plays an important role not only as a palliative treatment, but also as a definitive treatment with curative intent. Case presentation Three men (64, 69, and 74 years old) underwent combination therapy of external beam radiation therapy (EBRT) and EBBT for endobronchial metastasis after lobectomy of stage I–II non-small cell lung cancer (NSCLC): 2 cases of squamous cell carcinoma and 1 of adenocarcinoma. We used a special source-centralizing applicator for EBBT to avoid eccentric distribution of the radiation dose. Follow-up was considered to start from the end of brachytherapy. None of our patients experienced severe adverse events, and none needed extensive outpatient treatment. Local control was achieved in all cases by a bronchoscopic evaluation. All patients were alive after 31, 38, and 92 months of follow-up, respectively. In the adenocarcinoma patient, two metastases to the lung were discovered 3 years after EBBT, and the patient underwent partial wedge resection. Conclusions EBBT may be a promising treatment with curative intent for endobronchial metastasis after surgery of NSCLC.Atsushi ItoDaisuke YamaguchiShinji KanedaKoji KawaguchiAkira ShimamotoMakiko KubookaYoshihito NomotoMotoshi TakaoBMCarticleEndobronchial metastasisEndobronchial brachytherapyDefinitive treatmentSurgeryRD1-811Neoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENWorld Journal of Surgical Oncology, Vol 19, Iss 1, Pp 1-5 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Endobronchial metastasis Endobronchial brachytherapy Definitive treatment Surgery RD1-811 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Endobronchial metastasis Endobronchial brachytherapy Definitive treatment Surgery RD1-811 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Atsushi Ito Daisuke Yamaguchi Shinji Kaneda Koji Kawaguchi Akira Shimamoto Makiko Kubooka Yoshihito Nomoto Motoshi Takao Endobronchial brachytherapy as definitive treatment for endobronchial metastasis after surgery of non-small cell lung cancer
description	Abstract Background Endobronchial metastasis is a very rare type of recurrence after lung cancer surgery. Surgical intervention may be difficult to perform due to the postoperative reduction in the activities of daily living (ADL) and the invasiveness associated with redo surgery. In such cases, endobronchial brachytherapy (EBBT) plays an important role not only as a palliative treatment, but also as a definitive treatment with curative intent. Case presentation Three men (64, 69, and 74 years old) underwent combination therapy of external beam radiation therapy (EBRT) and EBBT for endobronchial metastasis after lobectomy of stage I–II non-small cell lung cancer (NSCLC): 2 cases of squamous cell carcinoma and 1 of adenocarcinoma. We used a special source-centralizing applicator for EBBT to avoid eccentric distribution of the radiation dose. Follow-up was considered to start from the end of brachytherapy. None of our patients experienced severe adverse events, and none needed extensive outpatient treatment. Local control was achieved in all cases by a bronchoscopic evaluation. All patients were alive after 31, 38, and 92 months of follow-up, respectively. In the adenocarcinoma patient, two metastases to the lung were discovered 3 years after EBBT, and the patient underwent partial wedge resection. Conclusions EBBT may be a promising treatment with curative intent for endobronchial metastasis after surgery of NSCLC.
format	article
author	Atsushi Ito Daisuke Yamaguchi Shinji Kaneda Koji Kawaguchi Akira Shimamoto Makiko Kubooka Yoshihito Nomoto Motoshi Takao
author_facet	Atsushi Ito Daisuke Yamaguchi Shinji Kaneda Koji Kawaguchi Akira Shimamoto Makiko Kubooka Yoshihito Nomoto Motoshi Takao
author_sort	Atsushi Ito
title	Endobronchial brachytherapy as definitive treatment for endobronchial metastasis after surgery of non-small cell lung cancer
title_short	Endobronchial brachytherapy as definitive treatment for endobronchial metastasis after surgery of non-small cell lung cancer
title_full	Endobronchial brachytherapy as definitive treatment for endobronchial metastasis after surgery of non-small cell lung cancer
title_fullStr	Endobronchial brachytherapy as definitive treatment for endobronchial metastasis after surgery of non-small cell lung cancer
title_full_unstemmed	Endobronchial brachytherapy as definitive treatment for endobronchial metastasis after surgery of non-small cell lung cancer
title_sort	endobronchial brachytherapy as definitive treatment for endobronchial metastasis after surgery of non-small cell lung cancer
publisher	BMC
publishDate	2021
url	https://doaj.org/article/8f46a6e280dd4cdf88aac13a6f2a6faa
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Endobronchial brachytherapy as definitive treatment for endobronchial metastasis after surgery of non-small cell lung cancer

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