Molecular interactions between parasite and mosquito during midgut invasion as targets to block malaria transmission

Abstract Despite considerable effort, malaria remains a major public health burden. Malaria is caused by five Plasmodium species and is transmitted to humans via the female Anopheles mosquito. The development of malaria vaccines against the liver and blood stages has been challenging. Therefore, mal...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yacob Keleta, Julian Ramelow, Liwang Cui, Jun Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/8f46a7124e52478886e45300c89c6b49
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:8f46a7124e52478886e45300c89c6b49
record_format	dspace
spelling	oai:doaj.org-article:8f46a7124e52478886e45300c89c6b492021-12-05T12:05:35ZMolecular interactions between parasite and mosquito during midgut invasion as targets to block malaria transmission10.1038/s41541-021-00401-92059-0105https://doaj.org/article/8f46a7124e52478886e45300c89c6b492021-11-01T00:00:00Zhttps://doi.org/10.1038/s41541-021-00401-9https://doaj.org/toc/2059-0105Abstract Despite considerable effort, malaria remains a major public health burden. Malaria is caused by five Plasmodium species and is transmitted to humans via the female Anopheles mosquito. The development of malaria vaccines against the liver and blood stages has been challenging. Therefore, malaria elimination strategies advocate integrated measures, including transmission-blocking approaches. Designing an effective transmission-blocking strategy relies on a sophisticated understanding of the molecular mechanisms governing the interactions between the mosquito midgut molecules and the malaria parasite. Here we review recent advances in the biology of malaria transmission, focusing on molecular interactions between Plasmodium and Anopheles mosquito midgut proteins. We provide an overview of parasite and mosquito proteins that are either targets for drugs currently in clinical trials or candidates of promising transmission-blocking vaccines.Yacob KeletaJulian RamelowLiwang CuiJun LiNature PortfolioarticleImmunologic diseases. AllergyRC581-607Neoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENnpj Vaccines, Vol 6, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Yacob Keleta Julian Ramelow Liwang Cui Jun Li Molecular interactions between parasite and mosquito during midgut invasion as targets to block malaria transmission
description	Abstract Despite considerable effort, malaria remains a major public health burden. Malaria is caused by five Plasmodium species and is transmitted to humans via the female Anopheles mosquito. The development of malaria vaccines against the liver and blood stages has been challenging. Therefore, malaria elimination strategies advocate integrated measures, including transmission-blocking approaches. Designing an effective transmission-blocking strategy relies on a sophisticated understanding of the molecular mechanisms governing the interactions between the mosquito midgut molecules and the malaria parasite. Here we review recent advances in the biology of malaria transmission, focusing on molecular interactions between Plasmodium and Anopheles mosquito midgut proteins. We provide an overview of parasite and mosquito proteins that are either targets for drugs currently in clinical trials or candidates of promising transmission-blocking vaccines.
format	article
author	Yacob Keleta Julian Ramelow Liwang Cui Jun Li
author_facet	Yacob Keleta Julian Ramelow Liwang Cui Jun Li
author_sort	Yacob Keleta
title	Molecular interactions between parasite and mosquito during midgut invasion as targets to block malaria transmission
title_short	Molecular interactions between parasite and mosquito during midgut invasion as targets to block malaria transmission
title_full	Molecular interactions between parasite and mosquito during midgut invasion as targets to block malaria transmission
title_fullStr	Molecular interactions between parasite and mosquito during midgut invasion as targets to block malaria transmission
title_full_unstemmed	Molecular interactions between parasite and mosquito during midgut invasion as targets to block malaria transmission
title_sort	molecular interactions between parasite and mosquito during midgut invasion as targets to block malaria transmission
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8f46a7124e52478886e45300c89c6b49
work_keys_str_mv	AT yacobkeleta molecularinteractionsbetweenparasiteandmosquitoduringmidgutinvasionastargetstoblockmalariatransmission AT julianramelow molecularinteractionsbetweenparasiteandmosquitoduringmidgutinvasionastargetstoblockmalariatransmission AT liwangcui molecularinteractionsbetweenparasiteandmosquitoduringmidgutinvasionastargetstoblockmalariatransmission AT junli molecularinteractionsbetweenparasiteandmosquitoduringmidgutinvasionastargetstoblockmalariatransmission
_version_	1718372269594509312

Molecular interactions between parasite and mosquito during midgut invasion as targets to block malaria transmission

Ejemplares similares