Crystal Structures of Two Immune Complexes Identify Determinants for Viral Infectivity and Type-Specific Neutralization of Human Papillomavirus

Crystal Structures of Two Immune Complexes Identify Determinants for Viral Infectivity and Type-Specific Neutralization of Human Papillomavirus

ABSTRACT Persistent, high-risk human papillomavirus (HPV) infection is the primary cause of cervical cancer. Neutralizing antibodies elicited by L1-only virus-like particles (VLPs) can block HPV infection; however, the lack of high-resolution structures has limited our understanding of the mode of v...

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Bibliographic Details
Main Authors: Zhihai Li, Daning Wang, Ying Gu, Shuo Song, Maozhou He, Jingjie Shi, Xinlin Liu, Shuangping Wei, Jinjin Li, Hai Yu, Qingbing Zheng, Xiaodong Yan, Timothy S. Baker, Jun Zhang, Jason S. McLellan, Shaowei Li, Ningshao Xia
Format: article
Language:EN
Published: American Society for Microbiology 2017
Subjects:
human papillomavirus
infectivity
neutralization
structure
type specificity
Microbiology
QR1-502
Online Access:https://doaj.org/article/8f49676155a44406a4ecc5706e4f012c
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