ATM phosphorylation of the actin-binding protein drebrin controls oxidation stress-resistance in mammalian neurons and C. elegans

Drebrin is an actin-binding protein known to play a role in neuronal dendritic spines but its precise regulation is unclear. Here, the authors report that DBN is activated by oxidative stress in an ATM-kinase dependent manner and increases resistance to oxidative stress in mice and in C. elegans.

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Autores principales:	Patricia Kreis, Christian Gallrein, Eugenia Rojas-Puente, Till G. A. Mack, Cristina Kroon, Viktor Dinkel, Claudia Willmes, Kai Murk, Susanne tom-Dieck, Erin M. Schuman, Janine Kirstein, Britta J. Eickholt
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8f4a9676b36d4e899073e6805e0d669d
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spelling	oai:doaj.org-article:8f4a9676b36d4e899073e6805e0d669d2021-12-02T14:40:18ZATM phosphorylation of the actin-binding protein drebrin controls oxidation stress-resistance in mammalian neurons and C. elegans10.1038/s41467-019-08420-w2041-1723https://doaj.org/article/8f4a9676b36d4e899073e6805e0d669d2019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08420-whttps://doaj.org/toc/2041-1723Drebrin is an actin-binding protein known to play a role in neuronal dendritic spines but its precise regulation is unclear. Here, the authors report that DBN is activated by oxidative stress in an ATM-kinase dependent manner and increases resistance to oxidative stress in mice and in C. elegans.Patricia KreisChristian GallreinEugenia Rojas-PuenteTill G. A. MackCristina KroonViktor DinkelClaudia WillmesKai MurkSusanne tom-DieckErin M. SchumanJanine KirsteinBritta J. EickholtNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Patricia Kreis Christian Gallrein Eugenia Rojas-Puente Till G. A. Mack Cristina Kroon Viktor Dinkel Claudia Willmes Kai Murk Susanne tom-Dieck Erin M. Schuman Janine Kirstein Britta J. Eickholt ATM phosphorylation of the actin-binding protein drebrin controls oxidation stress-resistance in mammalian neurons and C. elegans
description	Drebrin is an actin-binding protein known to play a role in neuronal dendritic spines but its precise regulation is unclear. Here, the authors report that DBN is activated by oxidative stress in an ATM-kinase dependent manner and increases resistance to oxidative stress in mice and in C. elegans.
format	article
author	Patricia Kreis Christian Gallrein Eugenia Rojas-Puente Till G. A. Mack Cristina Kroon Viktor Dinkel Claudia Willmes Kai Murk Susanne tom-Dieck Erin M. Schuman Janine Kirstein Britta J. Eickholt
author_facet	Patricia Kreis Christian Gallrein Eugenia Rojas-Puente Till G. A. Mack Cristina Kroon Viktor Dinkel Claudia Willmes Kai Murk Susanne tom-Dieck Erin M. Schuman Janine Kirstein Britta J. Eickholt
author_sort	Patricia Kreis
title	ATM phosphorylation of the actin-binding protein drebrin controls oxidation stress-resistance in mammalian neurons and C. elegans
title_short	ATM phosphorylation of the actin-binding protein drebrin controls oxidation stress-resistance in mammalian neurons and C. elegans
title_full	ATM phosphorylation of the actin-binding protein drebrin controls oxidation stress-resistance in mammalian neurons and C. elegans
title_fullStr	ATM phosphorylation of the actin-binding protein drebrin controls oxidation stress-resistance in mammalian neurons and C. elegans
title_full_unstemmed	ATM phosphorylation of the actin-binding protein drebrin controls oxidation stress-resistance in mammalian neurons and C. elegans
title_sort	atm phosphorylation of the actin-binding protein drebrin controls oxidation stress-resistance in mammalian neurons and c. elegans
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/8f4a9676b36d4e899073e6805e0d669d
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ATM phosphorylation of the actin-binding protein drebrin controls oxidation stress-resistance in mammalian neurons and C. elegans

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