Role of Pyroptosis in Diabetes and Its Therapeutic Implications

Abdullah Al Mamun,1 Yanqing Wu,2 Fatema Nasrin,3,4 Afroza Akter,5 Masuma Afrin Taniya,6 Fahad Munir,7 Chang Jia,8 Jian Xiao1 1Department of Hand Surgery and Peripheral Neurosurgery, The First Affiliated Hospital and School of Pharmaceutical Sciences, Wenzhou, Zhejiang Province, 325035, People&rs...

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Autores principales:	Al Mamun A, Wu Y, Nasrin F, Akter A, Taniya MA, Munir F, Jia C, Xiao J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	diabetes pyroptosis gsdmd nlrp3 caspase-1 il-1β il-18 Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/8f4b3e5c88ae4f4aaf23c1754f238826
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spelling	oai:doaj.org-article:8f4b3e5c88ae4f4aaf23c1754f2388262021-12-02T16:51:44ZRole of Pyroptosis in Diabetes and Its Therapeutic Implications1178-7031https://doaj.org/article/8f4b3e5c88ae4f4aaf23c1754f2388262021-05-01T00:00:00Zhttps://www.dovepress.com/role-of-pyroptosis-in-diabetes-and-its-therapeutic-implications-peer-reviewed-fulltext-article-JIRhttps://doaj.org/toc/1178-7031Abdullah Al Mamun,1 Yanqing Wu,2 Fatema Nasrin,3,4 Afroza Akter,5 Masuma Afrin Taniya,6 Fahad Munir,7 Chang Jia,8 Jian Xiao1 1Department of Hand Surgery and Peripheral Neurosurgery, The First Affiliated Hospital and School of Pharmaceutical Sciences, Wenzhou, Zhejiang Province, 325035, People’s Republic of China; 2Institute of Life Sciences, Wenzhou University, Wenzhou, Zhejiang Province, 325035, People’s Republic of China; 3Institute of Health and Biomedical Innovation, Translational Research Institute, Brisbane, Australia; 4School of Clinical Sciences, Queensland University of Technology, Brisbane, Australia; 5Department of Microbiology, Noakhali Science and Technology University, Noakhali, Bangladesh; 6Department of Life Sciences, School of Environment and Life Sciences, Independent University, Bangladesh, Dhaka, 1229, Bangladesh; 7Department of Hepatobiliary Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang Province, People’s Republic of China; 8Pediatric Research Institute, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, 325027, Zhejiang Province, People’s Republic of ChinaCorrespondence: Jian XiaoMolecular Pharmacology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang Province, 325035, People’s Republic of ChinaEmail xfxj2000@126.comAbstract: Pyroptosis is mainly considered as a new pro-inflammatory mediated-programmed cell death. In addition, pyroptosis is described by gasdermin-induced pore formation on the membrane, cell swelling and rapid lysis, and several pro-inflammatory mediators interleukin-1β (IL-1β) and interleukin-18 (IL-18) release. Extensive studies have shown that pyroptosis is commonly involved by activating the caspase-1-dependent canonical pathway and caspase-4/5/11-dependent non-canonical pathway. However, pyroptosis facilitates local inflammation and inflammatory responses. Current researches have reported that pyroptosis promotes the progression of several diabetic complications. Emerging studies have suggested that some potential molecules targeting the pyroptosis and inflammasome signaling pathways could be a novel therapeutic avenue for managing and treating diabetes and its complications in the near future. Our narrative review concisely describes the possible mechanism of pyroptosis and its progressive understanding of the development of diabetic complications.Keywords: diabetes, pyroptosis, GSDMD, NLRP3, caspase-1, IL-1β, IL-18Al Mamun AWu YNasrin FAkter ATaniya MAMunir FJia CXiao JDove Medical Pressarticlediabetespyroptosisgsdmdnlrp3caspase-1il-1βil-18PathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol Volume 14, Pp 2187-2206 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	diabetes pyroptosis gsdmd nlrp3 caspase-1 il-1β il-18 Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	diabetes pyroptosis gsdmd nlrp3 caspase-1 il-1β il-18 Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Al Mamun A Wu Y Nasrin F Akter A Taniya MA Munir F Jia C Xiao J Role of Pyroptosis in Diabetes and Its Therapeutic Implications
description	Abdullah Al Mamun,1 Yanqing Wu,2 Fatema Nasrin,3,4 Afroza Akter,5 Masuma Afrin Taniya,6 Fahad Munir,7 Chang Jia,8 Jian Xiao1 1Department of Hand Surgery and Peripheral Neurosurgery, The First Affiliated Hospital and School of Pharmaceutical Sciences, Wenzhou, Zhejiang Province, 325035, People’s Republic of China; 2Institute of Life Sciences, Wenzhou University, Wenzhou, Zhejiang Province, 325035, People’s Republic of China; 3Institute of Health and Biomedical Innovation, Translational Research Institute, Brisbane, Australia; 4School of Clinical Sciences, Queensland University of Technology, Brisbane, Australia; 5Department of Microbiology, Noakhali Science and Technology University, Noakhali, Bangladesh; 6Department of Life Sciences, School of Environment and Life Sciences, Independent University, Bangladesh, Dhaka, 1229, Bangladesh; 7Department of Hepatobiliary Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang Province, People’s Republic of China; 8Pediatric Research Institute, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, 325027, Zhejiang Province, People’s Republic of ChinaCorrespondence: Jian XiaoMolecular Pharmacology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang Province, 325035, People’s Republic of ChinaEmail xfxj2000@126.comAbstract: Pyroptosis is mainly considered as a new pro-inflammatory mediated-programmed cell death. In addition, pyroptosis is described by gasdermin-induced pore formation on the membrane, cell swelling and rapid lysis, and several pro-inflammatory mediators interleukin-1β (IL-1β) and interleukin-18 (IL-18) release. Extensive studies have shown that pyroptosis is commonly involved by activating the caspase-1-dependent canonical pathway and caspase-4/5/11-dependent non-canonical pathway. However, pyroptosis facilitates local inflammation and inflammatory responses. Current researches have reported that pyroptosis promotes the progression of several diabetic complications. Emerging studies have suggested that some potential molecules targeting the pyroptosis and inflammasome signaling pathways could be a novel therapeutic avenue for managing and treating diabetes and its complications in the near future. Our narrative review concisely describes the possible mechanism of pyroptosis and its progressive understanding of the development of diabetic complications.Keywords: diabetes, pyroptosis, GSDMD, NLRP3, caspase-1, IL-1β, IL-18
format	article
author	Al Mamun A Wu Y Nasrin F Akter A Taniya MA Munir F Jia C Xiao J
author_facet	Al Mamun A Wu Y Nasrin F Akter A Taniya MA Munir F Jia C Xiao J
author_sort	Al Mamun A
title	Role of Pyroptosis in Diabetes and Its Therapeutic Implications
title_short	Role of Pyroptosis in Diabetes and Its Therapeutic Implications
title_full	Role of Pyroptosis in Diabetes and Its Therapeutic Implications
title_fullStr	Role of Pyroptosis in Diabetes and Its Therapeutic Implications
title_full_unstemmed	Role of Pyroptosis in Diabetes and Its Therapeutic Implications
title_sort	role of pyroptosis in diabetes and its therapeutic implications
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/8f4b3e5c88ae4f4aaf23c1754f238826
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Role of Pyroptosis in Diabetes and Its Therapeutic Implications

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